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Featured researches published by Pcs Tsang.


Apmis | 2006

Interspecies variation in Candida biofilm formation studied using the Calgary biofilm device.

Nb Parahitiyawa; Yh Samaranayake; Lp Samaranayake; J. Ye; Pcs Tsang; Bpk Cheung; J. Y. Y. Yau; Skw Yeung

An in vitro assay to study multiple Candida biofilms, in parallel, has been carried out using the Calgary biofilm device (CBD). We here report: i) standardization of the CBD for Candida albicans biofilm formation, ii) kinetics of C. albicans biofilm formation, iii) biofilm formation by five Candida species, and iv) effect of dietary carbohydrates on biofilm formation. The biofilm metabolic activity on all CBD pegs was similar (p=0.6693) and C. albicans biofilm formation revealed slow growth up to 36 h and significantly higher growth up to 48 h (p<0.001). Significant differences in total biofilm metabolic activity were seen for glucose, fructose and lactose grown C. albicans compared with sucrose and maltose grown yeasts. Candida krusei developed the largest biofilm mass (p<0.05) relative to C. albicans, C. glabrata, C. dubliniensis and C. tropicalis. Scanning electron microscopy revealed that C. krusei produced a thick multilayered biofilm of pseudohyphal forms embedded within the polymer matrix, whereas C. albicans, C. dubliniensis and C. tropicalis biofilms consisted of clusters or chains of cells with sparse extracellular matrix material. We conclude that CBD is a useful, simple, low cost miniature device for parallel study of Candida biofilms and factors modulating this phenomenon.


Medical Mycology | 1997

Adenine auxotrophic heterozygosity in Candida krusei

By Cao; Pcs Tsang; T Wu; Lp Samaranayake; J Wang

Candida krusei CK 18 carries heterozygosity for a recessive adenine biosynthesis allele, as it can be induced by UV irradiation to form adenine mutants at high frequency. The resultant mutants were characterized with the phenotype of red colony and residual growth on minimal media. The majority of the descendant prototrophic segregates were capable of continuous segregation to adenine mutants, suggesting gene conversion as one possible mechanism for the occurrence of the adenine auxotroph in the isolate.


Archive | 2015

Blended learning and PBL: An interactional ethnographic approach to understanding knowledge construction in situ

Sm Bridges; Jl Green; Mg Botelho; Pcs Tsang


Microbios | 1996

A disc plate assay for characterization of the effect of interaction between polyenes and azoles on growth of Candida albicans CA12

By Cao; Pcs Tsang; Dnc Tsang; Lp Samaranayake; J Wang


Archive | 1995

Oral yeasts and coliforms in HIV-infected patients in Hong Kong

Pcs Tsang; Lp Samaranayake; Ss Lee; P Li; Raj G. Nair


Archive | 2015

Candida albicans SAP9: a gene with novel function in hyphal development in Candida albicans

H Yang; Pcs Tsang; Olt Lam; Ehn Pow; Wk Tsang


Archive | 2014

SAP7 contributes to Candida albicans invasion to oral epithelial cells

H Yang; Pcs Tsang; Ehn Pow; Olt Lam; Wk Tsang


Archive | 2014

Reduced level of induced endocytosis in Candida albicans sap7 mutants

H Yang; Pcs Tsang; Ehn Pow; Pwk Tsang


Archive | 2013

PBL2.0.: Infusing Educational Technologies For Synchronous Blended Inquiry

Sm Bridges; Cky Yiu; Mg Botelho; Ecm Lo; Pcs Tsang; Rm Watt; Y Yang; Jw Wong


Archive | 2013

Effect of Er,Cr:YSGG laser on biofilm adhered on zirconia surfaces

Ehn Pow; Ecm Tse; Pcs Tsang

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Ehn Pow

University of Hong Kong

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Mg Botelho

University of Hong Kong

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Sm Bridges

University of Hong Kong

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Wk Leung

University of Hong Kong

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Cky Yiu

University of Hong Kong

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By Cao

The Chinese University of Hong Kong

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Cpj McGrath

University of Hong Kong

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J Wang

The Chinese University of Hong Kong

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Lijian Jin

University of Hong Kong

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