Pedro Costa
Oporto Polytechnic Institute
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Publication
Featured researches published by Pedro Costa.
Molecular Diagnosis & Therapy | 2014
Lídia Cunha; Ildiko Horvath; Sara Ferreira; Joana Lemos; Pedro Costa; Domingos Vieira; Dániel S. Veres; Krisztián Szigeti; Teresa Summavielle; Domokos Máthé; Luís F. Metello
Translational research is changing the practice of modern medicine and the way in which health problems are approached and solved. The use of small-animal models in basic and preclinical sciences is a major keystone for these kinds of research and development strategies, representing a bridge between discoveries at the molecular level and clinical implementation in diagnostics and/or therapeutics. The development of high-resolution in vivo imaging technologies provides a unique opportunity for studying disease in real time, in a quantitative way, at the molecular level, along with the ability to repeatedly and non-invasively monitor disease progression or response to treatment. The greatest advantages of preclinical imaging techniques include the reduction of biological variability and the opportunity to acquire, in continuity, an impressive amount of unique information (without interfering with the biological process under study) in distinct forms, repeated or modulated as needed, along with the substantial reduction in the number of animals required for a particular study, fully complying with 3R (Replacement, Reduction and Refinement) policies. The most suitable modalities for small-animal in vivo imaging applications are based on nuclear medicine techniques (essentially, positron emission tomography [PET] and single photon emission computed tomography [SPECT]), optical imaging (OI), computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance spectroscopy imaging (MRSI), and ultrasound. Each modality has intrinsic advantages and limitations. More recently, aiming to overcome the inherent limitations of each imaging modality, multimodality devices designed to provide complementary information upon the pathophysiological process under study have gained popularity. The combination of high-resolution modalities, like micro-CT or micro-MRI, with highly sensitive techniques providing functional information, such as micro-PET or micro-SPECT, will continue to broaden the horizons of research in such key areas as infection, oncology, cardiology, and neurology, contributing not only to the understanding of the underlying mechanisms of disease, but also providing efficient and unique tools for evaluating new chemical entities and candidate drugs. The added value of small-animal imaging techniques has driven their increasing use by pharmaceutical companies, contract research organizations, and research institutions.
Bulletin of Environmental Contamination and Toxicology | 2017
J. Lemos; Teresa Neuparth; M. Trigo; Pedro Costa; D. Vieira; L. Cunha; F. Ponte; P. S. Costa; Luís F. Metello; António Paulo Carvalho
This study investigated to what extent a single exposure to low doses of ionizing radiation can induce genotoxic damage in irradiated adult zebrafish (Danio rerio) and its non-irradiated F1 progeny. Four groups of adult zebrafish were irradiated with a single dose of X-rays at 0 (control), 100, 500 and 1000xa0mGy, respectively, and couples of each group were allowed to reproduce following irradiation. Blood of parental fish and whole-body offspring were analysed by the comet assay for detection of DNA damage. The level of DNA damage in irradiated parental fish increased in a radiation dose-dependent manner at day 1 post-irradiation, but returned to the control level thereafter. The level of DNA damage in the progeny was directly correlated with the parental irradiation dose. Results highlight the genotoxic risk of a single exposure to low-dose ionizing radiation in irradiated individuals and also in its non-irradiated progeny.
Nuclear Medicine and Biology | 2014
Pedro Costa; Luís F. Metello; Francisco Alves; M. Duarte Naia
Proteção 2012 | 2012
Luís F. Metello; Lídia Cunha; Pedro Costa; Domingos Vieira; Francisco Alves; Maria Filomena Botelho; W. Gelbart; Christoph Artner; Michael Nader; Roger Schibli; Mikael Jensen
Proteção 2012 | 2012
Joana Lemos; Pedro Costa; Lídia Cunha; António Paulo Carvalho; Vitor Vasconcelos; Regina Silva; Sílvia Fernandes; J.A.M. Santos; Micaela Cunha; Paulo Crespo; Luís F. Metello; Filipe Couto Alves
Milan 2012 - Annual Congress of the European Association of Nuclear Medicine | 2012
Luís F. Metello; Pedro Costa; Joana Lemos; Sara Ferreira; Domingos Vieira; Abigaíl Fonseca; Sofia Soares; Lídia Cunha
Milan 2012 - Annual Congress of the European Association of Nuclear Medicine | 2012
Pedro Costa; Lídia Cunha; Tânia Oliveira; Ana Rebelo; A. Nunes; Marta Milhões; Elisa Botelho; José Alexandre Silva; Rosa Castro; Laucena Pires; M. Faria João; Luís F. Metello
Milan 2012 - Annual Congress of the European Association of Nuclear Medicine | 2012
Lídia Cunha; Joana Bravo; Pedro Costa; Sílvia Fernandes; Marta Oliveira; Rosa Castro; Luís F. Metello; Teresa Summavielle
Milan 2012 - Annual Congress of the European Association of Nuclear Medicine | 2012
Pedro Costa; Lídia Cunha; Sofia Soares; Ângela Mendes; Ana Queiroz; A. Nunes; Elisabete Ferreira; Elisa Botelho; Maria C. Sousa; Rosa Castro; Laucena Pires; M. Faria João; Luís F. Metello
Física 2012 | 2012
Pedro Costa; Luís F. Metello; M. Duarte Naia