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Dive into the research topics where Pengcheng Huang is active.

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Featured researches published by Pengcheng Huang.


Analytical Chemistry | 2015

Target-Triggered Switching on and off the Luminescence of Lanthanide Coordination Polymer Nanoparticles for Selective and Sensitive Sensing of Copper Ions in Rat Brain

Pengcheng Huang; Fang-Ying Wu; Lanqun Mao

Copper ions (Cu(2+)) in the central nervous system play a crucial role in the physiological and pathological events, so simple, selective, and sensitive detection of cerebral Cu(2+) is of great importance. In this work, we report a facile yet effective fluorescent method for sensing of Cu(2+) in rat brain using one kind of lanthanide coordination polymer nanoparticle, adenosine monophosphate (AMP) and terbium ion (Tb(3+)), i.e., AMP-Tb, as the sensing platform. Initially, a cofactor ligand, 5-sulfosalicylic acid (SSA), as the sensitizer, was introduced into the nonluminescent AMP-Tb suspension, resulting in switching on the luminescence of AMP-Tb by the removal of coordinating water molecules and concomitant energy transfer from SSA to Tb(3+). The subsequent addition of Cu(2+) into the resulting SSA/AMP-Tb can strongly quench the fluorescence because the specific coordination interaction between SSA and Cu(2+) rendered energy transfer from SSA to Tb(3+) inefficient. The decrease ratio of the fluorescence intensities of SSA/AMP-Tb at 550 nm show a linear relationship for Cu(2+) within the concentration range from 1.5 to 24 μM with a detection limit of 300 nM. The method demonstrated here is highly selective and is free from the interference of metal ions, amino acids, and the biological species commonly existing in the brain such as dopamine, lactate, and glucose. Eventually, by combining the microdialysis technique, the present method has been successfully applied in the detection of cerebral Cu(2+) in rat brain with the basal dialysate level of 1.91 ± 0.40 μM (n = 3). This method is very promising to be used for investigating the physiological and pathological events that cerebral Cu(2+) participates in.


New Journal of Chemistry | 2017

Highly selective and sensitive detection of heparin based on competition-modulated assembly and disassembly of fluorescent gold nanoclusters

Sha Li; Pengcheng Huang; Fangying Wu

We report a facile yet effective strategy for the fluorescence assay of heparin based on assembly and disassembly of the glutathione-protected gold nanoclusters (GSH-Au NCs) modulated via the competitive interaction of cetyltrimethyl ammonium bromide (CTAB) with heparin and GSH. Firstly, CTAB can increase the fluorescence of Au NCs by forming a nanocomposite via electrostatic and hydrophobic self-assembly. By adding heparin to the assay, CTAB is removed from the nanocomposites because of its higher affinity for heparin, quenching the fluorescence signal. Such a fluorescence feature induced via assembly and disassembly of the NCs enables our assay to possess high selectivity and sensitivity. The linear response toward heparin was obtained over the range 0.1–1.6 μg mL−1 with a low detection limit of 0.075 μg mL−1. Furthermore, satisfactory sensing perfomance for heparin in human serum makes this method hold great promise in heparin-related biomedical applications.


Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2018

Colorimetric detection of melamine in milk based on Triton X-100 modified gold nanoparticles and its paper-based application

Nan Gao; Pengcheng Huang; Fang-Ying Wu

In this study, we have developed a method for rapid, highly efficient and selective detection of melamine. The negatively charged citrate ions form an electrostatic layer on gold nanoparticles (AuNPs) and keep the NPs dispersed and stable. When citrate-capped AuNPs were further modified with Triton X-100, it stabilized the AuNPs against the conditions of high ionic strength and a broad pH range. However, the addition of melamine caused the destabilization and aggregation of NPs. This may be attributed to the interaction between melamine and the AuNPs through the ligand exchange with citrate ions on the surface of AuNPs leading Triton X-100 to be removed. As a result, the AuNPs were unstable, resulting in the aggregation. The aggregation induced a wine red-to-blue color change, and a new absorption peak around 630nm appeared. Triton X-100-AuNPs could selectively detect melamine at the concentration as low as 5.1nM. This probe was successfully applied to detect melamine in milk. Furthermore, paper-based quantitative detection system using this colorimetric probe was also demonstrated by integrating with a smartphone.


RSC Advances | 2017

Specific pH effect for selective colorimetric assay of glutathione using anti-aggregation of label-free gold nanoparticles

Jian-Fang Li; Pengcheng Huang; Fangying Wu

An operationally simple colorimetric method for measuring glutathione (GSH) concentration was developed using anti-aggregation of gold nanoparticles (AuNPs) in this work. At a pH of 5.8, cysteine (Cys) could rapidly induce the aggregation of AuNPs, thereby resulting in color change and AuNPs absorbance ratio (A650 nm/A520 nm) change. However, the added glutathione (GSH) can cause the anti-aggregation process to occur. This method was based on the regulation of pH, which on one hand can selectively detect GSH over Cys by the process of anti-aggregation of AuNPs and on the other hand can distinguish GSH from homocysteine (Hcys), and cystine (Cye) through specific selectivity. Under optical conditions, the detection of GSH can be finished within 5 min. The concentration range of the probe is 0.1–1.0 μM and the limit of detection (LOD) can be reached to 20.3 nM.


Methods and Applications in Fluorescence | 2017

A highly selective turn-on fluorescent probe for Al3+ in aqueous solution based on quinoline Schiff-base

Pengcheng Huang; Hao Fang; Jing-Jing Xiong; Fang-Ying Wu

A new Al3+-specific fluorescent probe NQ was designed and synthesized from 2-hydroxy-1-naphthaldehyde and 2-aminoquinoline. Upon the addition of Al3+, the fluorescent intensity of NQ was significantly enhanced compared with other examined metal ions in aqueous solution. The result of a Jobs plot indicated the formation of a 1:1 complex between the probe and Al3+, and the possible binding mode of the system between NQ and Al3+ was clarified by IR analysis and 1H NMR titration. Moreover, other metal ions examined had little effect on the detection of Al3+. The detection limit of NQ for Al3+ detection was 1.98 μM, which is lower than the level (7.4 μM) in drinking water defined by the World Health Organization. In addition, the fluorescent probe NQ could be recyclable simply through treatment with a proper reagent such as F-, and could also be used for the detection of Al3+ in real samples.


Sensors and Actuators B-chemical | 2016

Colorimetric detection of Cu2+ in aqueous solution and on the test kit by 4-aminoantipyrine derivatives

Jing-Jing Xiong; Pengcheng Huang; Chen-Yang Zhang; Fangying Wu


Analyst | 2015

Ultrasensitive colorimetric assay of cadmium ion based on silver nanoparticles functionalized with 5-sulfosalicylic acid for wide practical applications.

Weiwei Jin; Pengcheng Huang; Fangying Wu; Li-Hua Ma


Mikrochimica Acta | 2016

Colorimetric determination of aluminum(III) based on the aggregation of Schiff base-functionalized gold nanoparticles

Pengcheng Huang; Jian-Fang Li; Xin Liu; Fangying Wu


Sensors and Actuators B-chemical | 2016

Colorimetric detection of thiocyanate based on anti-aggregation of gold nanoparticles in the presence of cetyltrimethyl ammonium bromide

Juan Song; Pengcheng Huang; Yiqun Wan; Fangying Wu


Analyst | 2015

Toward selective, sensitive, and discriminative detection of Hg2+ and Cd2+ via pH-modulated surface chemistry of glutathione-capped gold nanoclusters

Pengcheng Huang; Sha Li; Nan Gao; Fangying Wu

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