Perupparampil A. Unnikrishnan

Preliminary investigations on the synthesis and antitumor activity of 3(2H)-furanones

Two triaryl-3(2H)-furanones were synthesized and their antitumor activity was evaluated. These compounds inhibited the proliferation of DLA cell line in vitro. In vivo studies also showed that these compounds were active against tumor cell proliferation.

Syntheses of epi-β-Santalene, β-Santalene and an Isomer of β-Santalene with 4-Methyl-4-pentenyl Side Chain

Abstract The olfactory characteristics of East Indian Sandalwood oil is mainly due to its major components α-santalol (1) and β-santalol (2), while many of the components like β-santalene (3) and epi-β-santalene (4) also contribute to the perfumery properties1. Since the pioneering work of Corey2, Brieger3 and Money4 a number of syntheses of these compounds have appeared5,6. Of late there has been great interest in the synthesis of certain minor components of the oil, like the isomer of β-santalene with 4-methyl-4-pentenyl side chain (5).

Simple, Efficient, and Stereoselective Oxidation of Triphenylfurans to cis‐But‐2‐ene‐1,4‐diones

Abstract Triphenylfurans are stereoselctively oxidized to cis‐but‐2‐ene‐1,4‐diones, suitable precursors of 3(2H)‐furanones, in very good yields using ammonium nitrate or potassium nitrate in 80% aqueous acetic acid.

Simple and Efficient One-Pot Synthesis of Nitriles from Amides and Oximes Using in Situ–Generated Burgess-Type Reagent

Abstract The dehydration of aldoximes and amides, and oxidation of benzoin are accomplished in one-pot using in situ–generated Burgess-type reagent.

Novel Burgess reagent mediated C-to-N aryl migration reaction in nitrones

Nitrones undergo useful transformations with Burgess reagent. The reaction ostensibly involves a [3 + 2] annulation across a σ-bond followed by rearrangement involving C-to-N aryl migration. On the basis of available experimental evidence, plausible mechanisms for the rearrangement and the overall conversion have been proposed.

Effect of a Strategically Positioned Methoxy Substituent on the Photochemistry of 3-Aryl-3H-1-Oxacyclopenta[l]Phenanthren-2-Ones

Irradiation of 3-methoxy-3-aryl-3H-1-oxacyclopenta[l]phenanthren-2-one derivatives 5a–d resulted in singlet-mediated decarbonylation reaction leading to the formation of phenanthrene derivatives 9a–d. The structure of the photoproduct was unequivocally established on the basis of X-ray crystallographic analysis.

Efficient one-pot synthesis of (anthracen-9-yl)methyl sulfane derivatives

Abstract A series of unsymmetrical (anthracen-9-yl)methyl sulfanes have been synthesized using a one-pot reaction from (anthracen-9-yl)methyl alcohol, thiourea, and the corresponding alkyl halide and also by a base-promoted one-pot reductive coupling of tosylhydrazones with thiols.