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Peter Ambrose Lander

Eli Lilly and Company

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Publication

Featured researches published by Peter Ambrose Lander.

Bioorganic & Medicinal Chemistry Letters | 2015

Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists

Timothy Paul Burkholder; Brian Eugene Cunningham; Joshua Ryan Clayton; Peter Ambrose Lander; Matthew L. Brown; Robert Anthony Doti; Gregory L. Durst; Chahrzad Montrose-Rafizadeh; Constance King; Harold E. Osborne; Robert M. Amos; Richard W. Zink; Lawrence E. Stramm; Thomas P. Burris; Guemalli R. Cardona; Debra L. Konkol; Charles Reidy; Michael E. Christe; Michael James Genin

The design, synthesis, and structure activity relationships for a novel series of indoles as potent, selective, thyroid hormone receptor β (TRβ) agonists is described. Compounds with >50× binding selectivity for TRβ over TRα were generated and evaluation of compound 1c from this series in a model of dyslipidemia demonstrated positive effects on plasma lipid endpoints in vivo.

Archive | 2008

Compounds and methods for modulating fxr

Michael Gregory Bell; Robert Anthony Doti; Matthew Scott Dowling; Michael James Genin; Peter Ambrose Lander; Tianwei Ma; Nathan Bryan Mantlo; Jason Matthew Ochoada; Lindsay Scott Stelzer; Ryan Edward Stites; Alan M. Warshawsky

Bioorganic & Medicinal Chemistry Letters | 2005

Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1).

Bryan H. Norman; Peter Ambrose Lander; Joseph Michael Gruber; Julian Stanley Kroin; Jeffrey Daniel Cohen; Louis Nickolaus Jungheim; James J. Starling; Kevin L. Law; Tracy D. Self; Linda B. Tabas; Daniel C. Williams; Donald C. Paul; Anne H. Dantzig

Bioorganic & Medicinal Chemistry Letters | 2005

3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists

David Andrew Neel; Matthew L. Brown; Peter Ambrose Lander; Timothy Alan Grese; Jean Marie Defauw; Robert Anthony Doti; Todd Fields; Sally Ann Kelley; Stephon C. Smith; Karen M. Zimmerman; Mitchell I. Steinberg; Prabhakar Kondaji Jadhav

Archive | 2003

Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators

Timothy Alan Grese; Prabhakar K. Jadhav; David Andrew Neel; Mitchell I. Steinberg; Peter Ambrose Lander

Archive | 2004

Indole-derivative modulators of steroid hormone nuclear receptors

Michael Gregory Bell; Konstantinos Gavardinas; Douglas Linn Gernert; Timothy Alan Grese; Prabhakar Kondaji Jadhav; Peter Ambrose Lander; Mitchell I. Steinberg

Archive | 2007

Compounds and Methods for Modulating Fx-Receptors

Michael Gregory Bell; Michael James Genin; Peter Ambrose Lander; Tianwei Ma; Lindsay Scott Stelzer; Robert Anthony Doti; Ryan Edward Stites; Francisco Javier Agejas-Chicharro; Melendo Ana Belen Bueno; Peter Rudolph Manninen; Jason Matthew Ochoada; Quanrong Shen; Alan M. Warshawsky

Archive | 2008

Compuestos derivados de [1,2,3]-tiazol-4-ilmetoxilo, agonista del receptor farnesoide x (fxr); composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar dislipidemia y enfermedades relacionadas.

Michael Gregory Bell; Robert Anthony Doti; Matthew Scott Dowling; Michael J. Genin; Peter Ambrose Lander; Tianwei Ma; Natha

Archive | 2007

Composés et méthodes de modulation de fxr

Michael Gregory Bell; Robert Anthony Doti; Matthew Scott Dowling; Michael J. Genin; Peter Ambrose Lander; Tianwei Ma; Nathan Bryan Mantlo; Jason Matthew Ochoada; Lindsay Scott Stelzer; Ryan Edward Stites; Alan M. Warshawsky

Archive | 2007

Verbindungen und verfahren zur modulierung von fx-rezeptoren Compounds and methods for modulating fx-receptors

Michael Gregory Bell; Robert Anthony Doti; Matthew Scott Dowling; Michael J. Genin; Peter Ambrose Lander; Tianwei Ma; Nathan Bryan Mantlo; Jason Matthew Ochoada; Lindsay Scott Stelzer; Ryan Edward Stites; Alan M. Warshawsky

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Collaboration

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Michael Gregory Bell

Eli Lilly and Company

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Robert Anthony Doti

Eli Lilly and Company

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Tianwei Ma

Eli Lilly and Company

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Alan M. Warshawsky

Eli Lilly and Company

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Jason Matthew Ochoada

Eli Lilly and Company

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Lindsay Scott Stelzer

Eli Lilly and Company

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Ryan Edward Stites

Eli Lilly and Company

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Michael J. Genin

University of Minnesota

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Nathan Bryan Mantlo

Merck

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Mitchell I. Steinberg

Eli Lilly and Company

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