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Dive into the research topics where Peter F. Hahn is active.

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Featured researches published by Peter F. Hahn.


Journal of Vascular and Interventional Radiology | 1998

PERCUTANEOUS RADIOFREQUENCY TISSUE ABLATION : DOES PERFUSION-MEDIATED TISSUE COOLING LIMIT COAGULATION NECROSIS ?

S. Nahum Goldberg; Peter F. Hahn; Kenneth K. Tanabe; Peter R. Mueller; Wolfgang Schima; Christos A. Athanasoulis; Carolyn C. Compton; Luigi Solbiati; G. Scott Gazelle

PURPOSE To determine, by decreasing hepatic perfusion during radiofrequency (RF) ablation, whether perfusion-mediated tissue cooling can explain the reduced coagulation observed in in vivo studies compared to that seen with RF application in ex vivo tissue. MATERIALS AND METHODS RF was applied in vivo with use of cooled-tip electrodes to normal porcine liver without (n = 8) and with balloon occlusion of the portal vein (n = 8), celiac artery (n = 3), or hepatic artery (n = 2), and to ex vivo calf liver (n = 10). In vivo trials of vasopressin (0.3-0.6 U/min) infusion during RF application with (n = 10) and without (n = 2) arterial balloon occlusion were also performed. Intraoperative RF was subsequently performed in seven patients with hepatic colorectal metastases with and without portal inflow occlusion. Remote thermometry was performed in four patients. RESULTS RF application (12 minutes) during portal venous occlusion produced larger areas of coagulation necrosis than RF with unaltered blood flow (2.9 cm +/- 0.1 vs 2.4 cm +/- 0.2 diameter; P < .01). With celiac and hepatic artery occlusion, coagulation diameter measured 2.7 cm +/- 0.2 and 2.5 cm +/- 0.1, respectively. Infusion of vasopressin without vascular occlusion reduced coagulation diameter to 1.1 cm. However, different methods of hepatic or celiac arterial balloon occlusion with simultaneous vasopressin infusion produced a mean 3.4 cm +/- 0.2 of necrosis. Coagulation in ex vivo liver was 2.9 cm +/- 0.1 in diameter. Clinical studies demonstrated greater coagulation diameter for metastases treated during portal inflow occlusion (4.0 cm +/- 1.3) than for tumors treated with normal blood flow (2.5 cm +/- 0.8; P < .05). Thermometry documented a 10 degrees C increase compared to baseline at 10 mm and 20 mm from the electrode after 5 minutes of portal inflow occlusion during constant RF application. CONCLUSIONS Perfusion-mediated tissue cooling reduces coagulation necrosis achievable with RF ablation. Reduction of blood flow during RF application increases coagulation in both an animal model and human liver metastases.


Radiographics | 2009

Hepatobiliary-specific MR Contrast Agents: Role in Imaging the Liver and Biliary Tree

Melanie K. Seale; O. Catalano; Sanjay Saini; Peter F. Hahn; Dushyant V. Sahani

Hepatobiliary-specific contrast agents are one of several classes of contrast agents available for magnetic resonance (MR) imaging of the liver. These agents are taken up by functioning hepatocytes and excreted in the bile, and their paramagnetic properties cause shortening of the longitudinal relaxation time (T1) of the liver and biliary tree. The three contrast agents that have been developed are mangafodipir trisodium (Mn-DPDP), gadobenate dimeglumine (Gd-BOPTA), and gadoxetic acid (Gd-EOB-DTPA). These three MR contrast agents vary in mode of administration and dose, mechanism of cellular uptake, degree of excretion through the biliary pathway, and imaging characteristics. In the liver, hepatobiliary-specific agents can be used to improve lesion detection, to characterize lesions as hepatocellular or nonhepatocellular, and to specifically characterize some hepatocellular lesions, notably focal nodular hyperplasia. Biliary excretion of these agents can be used to evaluate the anatomic structure and function of the biliary tree. In the future, hepatobiliary-specific contrast agents may have wider applications, such as grading of cirrhosis and quantification of liver function.


Radiology | 2008

Incidental Adrenal Lesions: Principles, Techniques, and Algorithms for Imaging Characterization

Giles W. Boland; Michael A. Blake; Peter F. Hahn; William W. Mayo-Smith

Incidental adrenal lesions are commonly detected at computed tomography, and lesion characterization is critical, particularly in the oncologic patient. Imaging tests have been developed that can accurately differentiate these lesions by using a variety of principles and techniques, and each is discussed in turn. An imaging algorithm is provided to guide radiologists toward the appropriate test to make the correct diagnosis.


Magnetic Resonance Imaging | 1988

The effects of iron oxides on proton relaxivity

Lee Josephson; Jerome Lewis; Paula Jacobs; Peter F. Hahn; David D. Stark

The magnetic properties and relaxivities of superparamagnetic, ferromagnetic and paramagnetic iron oxides are presented and compared. The iron in colloids of ferromagnetic iron oxide has a large spin-spin relaxivity and a small spin-lattice relaxivity. The iron in colloids of paramagnetic iron oxide has a low spin-spin and spin-lattice relaxivity. The iron in colloids of highly dispersed superparamagnetic iron oxides has a large spin-spin relaxivity and a large spin-lattice relaxivity. Superparamagnetic colloids with various particle sizes in solution have been made by varying the number of superparamagnetic iron oxide crystals per particles in solution. Superparamagnetic colloids of larger solution particle size have a lower spin-lattice relaxivity than colloids comprised of smaller solution particle sizes.


The Journal of Urology | 1999

Imaging guided biopsy of renal masses: indications, accuracy and impact on clinical management.

Bradford J. Wood; Mohammed A. Khan; Francis J. McGovern; Mukesh G. Harisinghani; Peter F. Hahn; Peter R. Mueller

PURPOSE We evaluated the indications, accuracy and impact of image guided biopsy of focal renal masses. MATERIALS AND METHODS We retrospectively reviewed 79 image guided renal biopsies in 73 patients. Indications, imaging, and histological and clinical features were analyzed. We assumed that nephrectomy, partial nephrectomy or surgical biopsy of suspicious masses would be done when no percutaneous biopsy had been performed. A change in management was defined as surgical to nonsurgical. RESULTS Clinical management was altered due to results in 32 of the 79 biopsies (41%) in cases managed nonoperatively, including positive and negative biopsies in those followed clinically and with imaging. Of 79 biopsies 49 (62%) were diagnosed positive for malignancy, including 15 (31%) that were not and 34 (69%) that were renal cell carcinoma. The histological diagnosis was negative on 25 biopsies (32%) and positive or negative on 74 (94%). All 5 of the 79 false-negative biopsies (6%) were due to insufficient tissue and involved highly suspicious imaging findings that required further evaluation, such as repeat biopsy or surgery. Renal cell carcinoma was identified in 4 of the 5 cases. In 12 of the 24 patients (50%) with a pre-biopsy history of nonrenal cancer biopsies were diagnostic of nonrenal cancer. No patient had major complications and in 4 small hematomas were treated with observation only. CONCLUSIONS Image guided renal mass biopsy is safe, reliable and accurate, and it changes clinical management in many cases by avoiding nephrectomy or other surgical options. Radiologists should promote imaging guided biopsy as a potentially useful option for managing suspicious or indeterminate renal masses.


Radiographics | 2009

Imaging-based Quantification of Hepatic Fat: Methods and Clinical Applications

Xiaozhou Ma; Nagaraj-Setty Holalkere; Avinash Kambadakone R; Mari Mino-Kenudson; Peter F. Hahn; Dushyant V. Sahani

Fatty liver disease comprises a spectrum of conditions (simple hepatic steatosis, steatohepatitis with inflammatory changes, and end-stage liver disease with fibrosis and cirrhosis). Hepatic steatosis is often associated with diabetes and obesity and may be secondary to alcohol and drug use, toxins, viral infections, and metabolic diseases. Detection and quantification of liver fat have many clinical applications, and early recognition is crucial to institute appropriate management and prevent progression. Histopathologic analysis is the reference standard to detect and quantify fat in the liver, but results are vulnerable to sampling error. Moreover, it can cause morbidity and complications and cannot be repeated often enough to monitor treatment response. Imaging can be repeated regularly and allows assessment of the entire liver, thus avoiding sampling error. Selection of appropriate imaging methods demands understanding of their advantages and limitations and the suitable clinical setting. Ultrasonography is effective for detecting moderate or severe fatty infiltration but is limited by lack of interobserver reliability and intraobserver reproducibility. Computed tomography allows quantitative and qualitative evaluation and is generally highly accurate and reliable; however, the results may be confounded by hepatic parenchymal changes due to cirrhosis or depositional diseases. Magnetic resonance (MR) imaging with appropriate sequences (eg, chemical shift techniques) has similarly high sensitivity, and MR spectroscopy provides unique advantages for some applications. However, both are expensive and too complex to be used to monitor steatosis.


American Journal of Roentgenology | 2006

Significance of incidental thyroid lesions detected on CT: correlation among CT, sonography, and pathology.

Sanjay K. Shetty; Michael M. Maher; Peter F. Hahn; Elkan F. Halpern; Suzanne L. Aquino

OBJECTIVE The purpose of our study was to determine the prevalence of malignancy in incidental abnormalities of the thyroid gland detected on CT and to determine the relative accuracy of characterizing these abnormalities on CT as compared with sonography and pathology. MATERIALS AND METHODS We searched our departments computerized clinical database for all thoracic and cervical CT scans in which a new abnormality was incidentally identified in the thyroid gland from 1998-2001. Two hundred thirty patients with abnormal findings in the gland on CT subsequently underwent thyroid sonography, and 118 of the 230 patients underwent a diagnostic biopsy or resection. CT and sonographic images were directly reviewed to identify imaging features of each thyroid abnormality, including the location, size, appearance, and presence or absence of calcifications. Associations were evaluated using Fishers exact test of significance and the Students t test. The overall rate of malignant and potentially malignant lesions among these incidental abnormalities of the thyroid gland was calculated. RESULTS CT findings matched the sonographic characterization in 122 patients (53.0%), correctly identified the dominant nodule but missed multinodularity in 69 (30.0%) patients, and underestimated the number of nodules in 24 (10.4%) patients. CT overestimated the number of nodules in 5 (2.2%) patients and was false-positive for lesions in 10 patients (4.3%). Ninety-one patients with a single or dominant nodule on CT had pathologic correlation: 7 nodules were malignant, 17 showed malignant potential, and 67 were benign. Of 27 patients with multinodular or enlarged thyroid glands on CT and histopathologic correlation, 2 lesions were malignant and 25 benign. The presence of punctate calcifications on CT significantly correlated to the presence of microcalcifications on sonography (p < 0.02). Benign nodules were significantly smaller (mean, 2.16 +/- 1.01 cm; range, 0.6-4.5 cm) than malignant and potentially malignant nodules (mean, 2.79 +/- 0.99 cm; range, 0.7-4.6 cm) (p = 0.01). Patients 35 years or younger who had a thyroid lesion on CT were more likely to have malignancy (p < 0.01). Overall, among incidentally detected lesions of the thyroid gland, there was at least a 3.9% rate of malignancy (95% CI: 1.8-7.3%) and 7.4% rate of malignant potential (95% CI: 4.4-11.6%). CONCLUSION There is at least an 11.3% prevalence of malignant or potentially malignant lesions among incidental thyroid abnormalities detected on CT. Patients 35 years or younger who have incidental abnormalities have a significantly greater rate of malignancy. No CT feature reliably distinguishes benign from malignant lesions in the thyroid gland. CT underestimates the number of nodules relative to sonography, which suggests that sonography is a useful adjunctive test after the incidental detection of a thyroid abnormality on CT.


Radiology | 2011

Characterization of Adrenal Masses by Using FDG PET: A Systematic Review and Meta-Analysis of Diagnostic Test Performance

Giles W. Boland; Ben A. Dwamena; Minal Jagtiani Sangwaiya; Alexander Goehler; Michael A. Blake; Peter F. Hahn; James A. Scott; Mannudeep K. Kalra

PURPOSE To perform a systematic review and meta-analysis of published data to determine the diagnostic utility of adrenal fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) for distinguishing benign from malignant adrenal disease. MATERIALS AND METHODS Data on FDG PET assessment in MEDLINE and other electronic databases (from inception to November 2009) and in subject matter-specific journals were evaluated and compared with histologic diagnoses and/or established clinical and imaging follow-up results. Methodologic quality was assessed by using Quality Assessment of Diagnostic Accuracy Studies criteria. Bivariate random-effects meta-analytical methods were used to estimate summary and subgroup-specific sensitivity, specificity, and receiver operating characteristic curves and to investigate the effects of study design characteristics and imaging procedure elements on diagnostic accuracy. RESULTS A total of 1391 lesions (824 benign, 567 malignant) in 1217 patients from 21 eligible studies were evaluated. Qualitative (visual) analysis of 841 lesions (in 14 reports) and quantitative analyses based on standardized uptake values (SUVs) for 824 lesions (in 13 reports) and standardized uptake ratios (SURs) for 562 lesions (in eight reports) were performed. Resultant data were highly heterogeneous, with a model-based inconsistency index of 88% (95% confidence interval [CI]: 79%, 98%). Mean sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio values for differentiating between benign and malignant adrenal disease were 0.97 (95% CI: 0.93, 0.98), 0.91 (95% CI: 0.87, 0.94), 11.1 (95% CI: 7.5, 16.3), 0.04 (95% CI: 0.02, 0.08), and 294 (95% CI: 107, 805), respectively, with no significant differences in accuracy among the visual, SUV, and SUR analyses. CONCLUSION Meta-analysis of combination PET-computed tomography (CT) reports revealed that FDG PET was highly sensitive and specific for differentiating malignant from benign adrenal disease. Diagnostic accuracy was not influenced by the type of imaging device (PET vs PET/CT), but specificity was dependent on the clinical status (cancer vs no cancer).


Journal of Computer Assisted Tomography | 2006

Using the K-edge to improve contrast conspicuity and to lower radiation dose with a 16-MDCT: a phantom and human study.

Sanjeeva P. Kalva; Dushyant V. Sahani; Peter F. Hahn; Sanjay Saini

Purpose: To study the effect of tube current (milliamperes; mA) and potential (peak kilovolt; kVp) on the attenuation values and contrast-to-noise ratios of iodine- and gadolinium-based contrast media (CM) for computed tomography angiography (CTA). Materials and Methods: Phantom Study: A water-filled phantom with five 20-mL syringes filled with 1:20 dilution of 282, 300, 370, and 400 milligrams of iodine per milliliter concentration CM and gadopentetate dimeglumine (Magnevist, Berlex Laboratories, Wayne, NJ, 0.5 mol/L) was scanned with a 16-multidetector CT using 80, 100, 120, and 140 kVp and 500-millisecond gantry rotation time. The milliampere was either fixed at 100, 200, 300, and 380 or automatically adjusted with noise indices of 15, 20, and 25 or manually adjusted to maintain a constant image noise. The attenuation value (Hounsfield unit; HU) and its standard deviation of CM in each syringe and of the water phantom were obtained. Statistical analysis was performed to determine difference between attenuation values and contrast medium-to-water contrast-to-noise ratios at various kVp and mA selection. Human Study: Three groups of patients had CTA for abdominal aortic aneurysm with similar computed tomography parameters, varying only in kVp selection of either 100 (group A), 120 (group B), or 140 (group C). Another group (group D) had CTA at 100 kVp but with the CM volume reduced to 60%. The CTA studies were evaluated for the quality of axial and 3D images; attenuation values in the aorta, superior mesenteric artery, and iliac arteries; image noise; and scanner-estimated radiation dose. Statistical analysis was performed to determine the difference in image quality and radiation dose among the groups. Results: Phantom Study: In comparison with 140 kVp, regardless of selected milliampere or noise indices, images acquired at 80, 100, and 120 kVp showed 90.8% to 94.2%, 47% to 49.7%, and 18.9% to 20.7% (P < 0.0001) increase in HU of iodine-based CM, respectively, and 62.9%, 39.6%, and 16.8% (P < 0.0001) increase in HU of gadolinium-based CM, respectively. Human Study: The axial images in all the groups were diagnostically acceptable. There was significantly inferior quality of axial images associated with greater image noise in group A and group D (P < 0.01) in comparison with group C, but there was no difference in the quality of 3D images among the 4 groups. In comparison with group C, there was significantly higher attenuation of the aorta, superior mesenteric artery, and iliac arteries in group A (P < 0.01), group B (P < 0.05), and group D (P < 0.01). The radiation dose (CT dose index volume) decreased to 12 ± 4 in groups A and D compared with 17 ± 4 in group B and 24 ± 5 in group C. Conclusions: Lower kVp increases the attenuation of iodinated and gadolinium CM. CTA of the abdominal aorta performed at low kVp results in higher attenuation in aorta with reduced radiation dose and without degrading the diagnostic image quality. The iodinated CM volume can be reduced by reducing kVp during CTA.


Radiographics | 2008

Vascular and Biliary Variants in the Liver : Implications for Liver Surgery

O. Catalano; Anandkumar H. Singh; Raul N. Uppot; Peter F. Hahn; Cristina R. Ferrone; Dushyant V. Sahani

Accurate preoperative assessment of the hepatic vascular and biliary anatomy is essential to ensure safe and successful hepatic surgery. Such surgical procedures range from the more complex, like tumor resection and partial hepatectomy for living donor liver transplantation, to others performed more routinely, like laparoscopic cholecystectomy. Modern noninvasive diagnostic imaging techniques, such as multidetector computed tomography (CT) and magnetic resonance (MR) imaging performed with liver-specific contrast agents with biliary excretion, have replaced conventional angiography and endoscopic cholangiography for evaluation of the hepatic vascular and biliary anatomy. These techniques help determine the best hepatectomy plane and help identify patients in whom additional surgical steps will be required. Preoperative knowledge of hepatic vascular and biliary anatomic variants is mandatory for surgical planning and to help reduce postoperative complications. Multidetector CT and MR imaging, with the added value of image postprocessing, allow accurate identification of areas at risk for venous congestion or devascularization. This information may influence surgical planning with regard to the extent of hepatic resection or the need for vascular reconstruction.

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Michael J. Lee

Royal College of Surgeons in Ireland

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