Peter Gavornik

Atherogenic versus non-atherogenic lipoprotein profiles in healthy individuals. is there a need to change our approach to diagnosing dyslipidemia?

The electrophoretic separation of lipoproteins on polyacrylamide gels enables the quantification of nonatherogenic and atherogenic plasma lipoproteins including small dense low density lipoprotein (sdLDL) particles, which represent the atherogenic lipoprotein subpopulations in plasma. This methodology could help distinguish between nonatherogenic hyperlipidemia, normolipidemia with an atherogenic lipoprotein profile, non-atherogenic normolipidemia, and atherogenic hyperlipidemia. According to our pilot research of a normolipidemic population, the atherogenic lipoprotein profile might be present in about 6% of normolipidemic young healthy individuals. Therefore, if confirmed by other studies, it will be necessary to consider a different diagnostic approach and risk stratification for patients with atherogenic normolipidemia (as well as non-atherogenic hypercholesterolemia).

Exercise Programme of Patients with Ischaemic Disease of Lower Limbs Stage II–III — Evaluation with Holter ECG Monitorings

Ischaemic disease of the lower extremities is not a rare clinical entity as shown from epidemiological studies (5). Kinesiotherapy has been employed with these patients in recent years (1, 12). Holter ECG monitoring is a suitable noninvasive technique for evaluation of these patients during such an exercise programme (5, 7).