Péter Keglevich
Budapest University of Technology and Economics
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Featured researches published by Péter Keglevich.
Molecules | 2012
Péter Keglevich; László Hazai; Gyorgy Kalaus; Csaba Szántay
The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties.
Heterocycles | 2013
Csaba Szántay; Péter Keglevich; László Hazai; Álmos Gorka-Kereskényi; Lilla Péter; Judit Gyenese; Zsófia Lengyel; Gyorgy Kalaus; Zsófia Dubrovay; Miklós Dékány; Erika Orbán; Ildikò Szabò; Zoltán Bánóczi
10-Bromovindoline and its 14,15-dihydro- and 14,15-cyclopropano derivatives were coupled in the position 16 with (L)- and (D)-tryptophan methyl esters. The tryptophan derivatives of vindoline were synthesized starting from the 16-carboxylic acid hydrazides viathe corresponding azides which were allowed to react with the amino acidesters. The new compounds showed antitumor activity against human leukemia (HL-60) cells in vitro.
Molecules | 2018
András Keglevich; Szabolcs Mayer; Réka Pápai; Áron Szigetvári; Zsuzsanna Sánta; Miklós Dékány; Csaba Szántay; Péter Keglevich; László Hazai
Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid. Halogenated 14,15-cyclopropanovindoline was prepared by reactions with iodoform and bromoform, respectively, in the presence of diethylzinc. Reactions of dichlorocarbene with vindoline resulted in the 10-formyl derivative. Unexpectedly, in the case of the dimer alkaloids vinblastine and vincristine, the rearranged products containing an oxirane ring in the catharanthine part were isolated from the reactions. The attempted epoxidation of vindoline and catharanthine also led to anomalous rearranged products. In the epoxidation reaction of vindoline, an o-quinonoid derivative was obtained, in the course of the epoxidation of catharanthine, a hydroxyindolenine type product and a spiro derivative formed by ring contraction reaction, were isolated. The coupling reaction of vindoline and the spiro derivative obtained in the epoxidation of catharanthine did not result in a bisindole alkaloid. Instead, two surprising vindoline trimers were discovered and characterized by NMR spectroscopy and mass spectrometry.
Journal of Peptide Science | 2018
Zoltán Bánóczi; András Keglevich; Ildikò Szabò; Ivan Ranđelović; Zita Hegedüs; Fruzsina L. Regenbach; Péter Keglevich; Zsófia Lengyel; Álmos Gorka-Kereskényi; Zsófia Dubrovay; Viktor Háda; Áron Szigetvári; Csaba Szántay; László Hazai; József Tóvári; Ferenc Hudecz
Some Vinca alkaloids (eg, vinblastine, vincristine) have been widely used as antitumor drugs for a long time. Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity. In our novel research program, we have prepared and identified new vindoline derivatives with moderate cytostatic activity.
Mini-reviews in Medicinal Chemistry | 2016
Péter Keglevich; Csaba Szántay; László Hazai
Galanthamine as an Amaryllidaceae alkaloid has an important role in the treatment of Alzheimers disease. Some efforts were made to elaborate the total synthesis, and hundreds of its derivatives were prepared to find a more effective molecule with advantageous properties. Moreover, almost every part of the tetracycle was changed; in members of the rings, in the nature and position of the heteroatoms, and ring-opened analogues were also synthesized. In this review the basic synthetic works and the most important derivatives and analogues are overviewed.
Current Organic Chemistry | 2014
Péter Keglevich; András Keglevich; László Hazai; Gyorgy Kalaus; Csaba Szántay
Arkivoc | 2009
Attila Makó; Péter Bakó; Áron Szöllösy; Tibor Bakó; Csaba Peltz; Péter Keglevich
Heterocycles | 2014
Csaba Szántay; Péter Keglevich; László Hazai; Zsófia Dubrovay; Gyorgy Kalaus
Heterocycles | 2012
Csaba Szántay; Péter Keglevich; Péter Kovács; László Hazai; Zsuzsanna Sánta; Zsófia Dubrovay; Viktor Háda; Gyorgy Kalaus
Tetrahedron Letters | 2015
Mátyás Milen; Péter Slégel; Péter Keglevich; Gyoergy Keglevich; Gyula Simig; Balázs Volk