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FEBS Letters | 1985

3'-Fluoro-2',3'-dideoxyribonucleoside 5'-triphosphates: terminators of DNA synthesis

Zurab G. Chidgeavadze; Andrei V. Scamrov; Robert Sh. Beabealashvilli; Eugenii I. Kvasyuk; Galina V. Zaitseva; Igor A. Mikhailopulo; Gotthard Kowollik; Peter Langen

It is shown that dNTP(3F) are terminators of DNA synthesis and may serve as very effective tools for DNA sequencing with E.coli DNA polymerase I and AMV reverse transcriptase. The dNTP(3F) are found to be chain terminator substrates for calf thymus terminal deoxyribonucleotidyl transferase but not for calf thymus DNA polymerase α. The optimal dNTP(3F) concentration for DNA sequencing by DNA polymerase I is found to be an order of magnitude lower than that of ddNTPs. dNTP(3F) produce a more clear sequence pattern than do ddNTPs.


Archive | 1987

Fluorinated nucleoside, process for their preparation and their use as a pharmaceutical product against aids

Eckart Matthes; Christine Lehmann; Dieter Scholz; Janta-Lipinski Martin Dr. Von; Klaus Gaertner; Peter Langen; Hans-Alfred Prof. Dr. Rosenthal


Archive | 1987

Fluorinated nucleosides,their preparation and their pharmaceutical use against AIDS

Eckart Matthes; Christine Lehmann; Dieter Dr. Scholz; Janta-Lipinski Martin Dr. Von; Klaus Gaertner; Peter Langen; Hans-Alfred Prof. Dr. Rosenthal


Archive | 1990

Prepn. of antiviral, esp. anti-AIDS agent - by mixing halo-contg. higher alkyl-glycerol-phospho-choline analogues with suitable carrier

Werner E G Prof Dr Mueller; Hans Brachwitz; Eckart Matthes; Peter Langen


Zeitschrift für Chemie | 2010

Nucleoside von Fluorzuckern; Aufspaltung des Epoxidringes von 1‐(5‐O‐Benzoyl‐2,3‐epoxy‐β‐D‐lyxofuranosyl)‐uracil mit Fluorwasserstoffsäure

Gotthard Kowollik; Peter Langen


Archive | 1989

Substituted pyrimidine nucleosides, process for their preparation and pharmaceutical compounds containing them

Eckart Matthes; Janta-Lipinski Martin Dr. Von; Dieter Scholz; Klaus Gaertner; Jürgen Schildt; Christine Lehmann; Peter Langen; Hans-Alfred Prof. Dr. Rosenthal


Zeitschrift für Chemie | 2010

Synthese von 5′‐Desoxy‐5′‐fluor‐orotidin

Gottfried Herrmann; Dieter Cech; Gotthart Kowollik; Peter Langen


Zeitschrift für Chemie | 2010

Nucleoside von Fluorzuckern; Synthese der 5′‐Desoxy‐5′‐fluor‐Derivate von 6‐Aza‐uridin und Ribofuranosyl‐thymin

Gotthard Kowollik; Manfred Schütt; Peter Langen; Georgi Demirow


Zeitschrift für Chemie | 2010

Hydroxymethylierung von 5′-Desoxy-5′-fluor-uridin

Gottfried Herrmann; Dieter Cech; Gotthard Kowollik; Peter Langen


Archive | 1969

Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides

Gerhard Etzold; Rainer Hintsche; Peter Langen

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Dieter Scholz

Humboldt University of Berlin

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Dieter Cech

Humboldt University of Berlin

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Gottfried Herrmann

Humboldt University of Berlin

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Jürgen Schildt

Max Delbrück Center for Molecular Medicine

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