Peter Palese
Salk Institute for Biological Studies
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Featured researches published by Peter Palese.
npj Vaccines | 2016
Raffael Nachbagauer; David Kinzler; Angela Choi; Ariana Hirsh; Édith Beaulieu; Nicolas Lecrenier; Bruce L. Innis; Peter Palese; Corey Mallett; Florian Krammer
Seasonal influenza virus vaccines are generally effective at preventing disease, but need to be well matched to circulating virus strains for maximum benefit. Influenza viruses constantly undergo antigenic changes because of their high mutation rate in the immunodominant haemagglutinin (HA) head domain, which necessitates annual re-formulation and re-vaccination for continuing protection. In case of pandemic influenza virus outbreaks, new vaccines need to be produced and quickly distributed. Novel influenza virus vaccines that redirect the immune response towards more conserved epitopes located in the HA stalk domain may remove the need for annual vaccine re-formulation and could also protect against emergent pandemic strains to which the human population is immunologically naive. One approach to create such universal influenza virus vaccines is the use of constructs expressing chimeric HAs. By sequential immunization with vaccine strains expressing the same conserved HA stalk domain and exotic HA heads to which the host is naive, antibodies against the stalk can be boosted to high titres. Here we tested a monovalent chimeric HA-based prototype universal influenza virus split virion vaccine candidate with and without AS03 adjuvant in primed mice. We found that the chimeric HA-based vaccination regimen induced higher stalk antibody titres than the seasonal vaccine. The stalk antibody responses were long lasting, cross-reactive to distantly related HAs and provided protection in vivo in a serum transfer challenge model. The results of this study are promising and support further development of a universal influenza vaccine candidate built on the chimeric HA technology platform.
Archive | 2013
Peter Palese; Adolfo Garcia-Sastre; Juliet Morrison; Maudry Laurent-Rolle
Archive | 2010
Megan Shaw; Peter Palese; Adolfo Garcia-Sastre; Silke Stertz; John A. T. Young; Renate König; Sumit K. Chanda
Archive | 2017
Peter Palese; Adolfo Garcia-Sastre; Florian Krammer; Megan E. Ermler
Archive | 2017
Adolfo Garcia-Sastre; Dirk Eggink; Florian Krammer; Natalie Pica; Peter Palese; Rafael A. Medina-Silva; Rong Hai
Archive | 2016
Teddy John Wohlbold; Veronika Chromikova; Philip Meade; Fatima Amanat; Ariana Hirsh; Raffael Nachbagauer; Gene S. Tan; Peter Palese; Florian Krammer
Archive | 2016
Raffael Nachbagauer; Talia Atlas; Angela Choi; Paul Bunduc; Adolfo Garcia-Sastre; Peter Palese; Randy A. Albrecht; Florian Krammer
Archive | 2014
Peter Palese; Adolfo Garcia-Sastre; Dmitriy Zamarin; James Allison; Jedd D. Wolchok
Archive | 2014
Peter Palese; J. Andrew; Nicole M. Bouvier; Randy A. Albrecht; Peter H. Goff; Florian Krammer; Christopher W. Seibert; Saad Rahmat; Jens Krause
Archive | 2013
Adolfo Garcia-Sastre; Peter Palese; Florian Krammer