Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Peter R. Galle is active.

Publication


Featured researches published by Peter R. Galle.


Gastrointestinal Endoscopy | 2009

Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violet

Martin Goetz; Tanja Toermer; Michael Vieth; Kerry B. Dunbar; Arthur Hoffman; Peter R. Galle; Markus F. Neurath; Peter Delaney; Ralf Kiesslich

BACKGROUNDnConfocal laser endomicroscopy (CLE) has been shown to reliably predict histology during ongoing endoscopy. To unmask lesions for CLE, chromoendoscopy has been mandated. Usually fluorescein then serves as a contrast agent for CLE, but it does not allow direct nuclear visualization, must be injected, leads to a transient skin discoloration, and may have allergic side effects.nnnOBJECTIVEnTo establish a single topical dye, cresyl violet (CV), for simultaneous chromoendoscopy and in vivo CLE of the lower GI tract.nnnDESIGNnAnimal preclinical study, prospective clinical trial.nnnSETTINGnMainz University Clinic (tertiary care center). PATIENTS, METHODS, AND INTERVENTIONS: To establish the staining characteristics and optimal concentration of CV, the ileum and colon of 7 BL6 mice were stained with CV (0.1%-2%), and in vivo confocal imaging was performed with FIVE1. In a subsequent clinical trial, 67 sites in 36 patients were topically stained with CV 0.13%, and subsurface serial images were generated at different depths with an endomicroscope.nnnMAIN OUTCOME MEASUREMENTSnPrediction of histology according to the Mainz confocal classification and nuclear visualization with topical CV.nnnRESULTSnEndomicroscopy with topical CV yielded (sub-)cellular details of normal mucosa, and regenerative and neoplastic changes at variable imaging depths in high resolution comparable to those with intravenous fluorescein. By cytoplasmic enrichment of CV, nuclear morphology could be negatively visualized. Reliable differentiation of nonneoplastic versus neoplastic changes during ongoing endoscopy and a high interobserver agreement based on the microscopic images generated in vivo could be achieved.nnnLIMITATIONSnSingle-center study, nonrandomized, limited number of patients.nnnCONCLUSIONSnCV can be applied topically and allows simultaneous chromoendoscopy and endomicroscopy with accurate prediction of histology with visualization of nuclear morphology. It may therefore be a single-agent alternative to chromoendoscopy and fluorescein in endomicroscopy.


Current Opinion in Gastroenterology | 2012

Mini-laparoscopy in the endoscopy unit.

A Hoffman; Fareed Rahman; Sanjay K. Murthy; Peter R. Galle; Ralf Kiesslich

Purpose of review The evaluation of liver histology is an important component of the diagnosis and staging of liver diseases. The most common technique employed to sample liver tissue for decades has been percutaneous liver biopsy. Although this is a relatively well tolerated technique in the early stages of liver disease, it carries a high risk of complications, particularly hemorrhage, in patients with advanced cirrhosis. Mini-laparoscopy allows macroscopic assessment and biopsy under direct vision and therefore is a well tolerated and effective technique. Recent findings The major advantages of this technique are direct visualization of the liver surface, thereby allowing inspection for morphologic changes of cirrhosis as well as targeted biopsies, the ability to immediately treat potential complications (bleeding and bile leakage), furthermore the peritoneal cavity can be visualized to stage gastrointestinal (GI) malignancies. Additionally, ‘blind’ percutaneous liver biopsy fails to establish a diagnosis in about 25% of cases, largely because of sampling error. Summary This technique presents the opportunity to visualize the surface of the liver and the peritoneal cavity, making it a valuable tool for liver biopsy. This review summarizes the technique of mini-laparoscopy and addresses its potential uses and limitations as a diagnostic modality.


Archive | 2015

Atlas of endomicroscopy

Ralf Kiesslich; Peter R. Galle; F Markus Neurath.


Archive | 2013

Dendritic Cells via NF- Induced by TLR Signaling in Primary EBV-Induced Gene 3 Transcription Is

Markus F Neurath; Hansjörg Schild; Mark Birkenbach; Richard S. Blumberg; Edward E. S. Nieuwenhuis; Ingrid Tubbe; Peter R. Galle; Stefan Wirtz; Christoph Becker; Massimo C. Fantini


Archive | 2013

This information is current as ProteinsGuanosine Exchange Activity on Rac Cell-APC Conjugation through Inhibition of Ezrin-Radixin-Moesin-Dependent T Azathioprine Suppresses

F. Neurath; Shinya Tanaka; Peter R. Galle; Xosé R. Bustelo; Brigitte Bartsch; Stefan Wirtz; Dennis Strand; Daniela Poppe; Imke Tiede; Gerhard Fritz


Society of Nuclear Medicine Annual Meeting Abstracts | 2012

Assessment of inflammatory activity in Crohn`s disease by FDG-PET. A comparative study with colonoscopy and magnetic resonance imaging

Andreas Helisch; Martin H. Holtmann; Manuela Uenzen; Anja Franzaring; Jonas Mudter; Martin Goetz; Peter R. Galle; Peter Bartenstein; Markus F Neurath; Mathias Schreckenberger


Archive | 2011

In vivo real time imaging of the liver with confocal endomicroscopy permits visualization of the temporospatial patterns of hepatocyte apoptosis Running head: In vivo imaging of hepatocyte apoptosis

Martin Goetz; Jacqueline V. Ansems; Peter R. Galle; Marcus Schuchmann; Ralf Kiesslich; I. Medizinische; Klinik und Poliklinik


/data/revues/00165107/v71i5/S0016510710012083/ | 2011

W1529: Confocal Endomicroscopy for the Diagnosis of Ultra-Structural Changes in Non-Erosive Reflux Disease (NERD)

Martin Goetz; Daniel Dillinger; Dorothy K. Chow; Aric J. Hui; Arthur Hoffman; Peter R. Galle; Joseph J Sung; Ralf Kiesslich


/data/revues/00165107/v71i5/S001651071001179X/ | 2011

W1500: High Definition Plus Endoscopy in Conjunction With Pan-Chromoendoscopy Does Not Lead to an Increased Yield for Intraepithelial Neoplasia in Patients With Long Lasting Crohn's Disease

Arthur Hoffman; Jana Strick; Fareed Rahman; Thorsten Hansen; Martin Goetz; Peter R. Galle; Markus F Neurath; Ralf Kiesslich


/data/revues/00165107/v63i5/S0016510706014313/ | 2011

Methylene Blue Aided Cholangioscopy for the Detection of Neoplastic Biliary Lesions

Arthur Hoffman; Ralf Kiesslich; Katharina Lammersdorf; Stefan Biesterfeld; Peter R. Galle; Markus F Neurath

Collaboration


Dive into the Peter R. Galle's collaboration.

Top Co-Authors

Avatar

Ralf Kiesslich

Helios Dr. Horst Schmidt Kliniken Wiesbaden

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Stefan Wirtz

University of Erlangen-Nuremberg

View shared research outputs
Top Co-Authors

Avatar

Michael Vieth

Johns Hopkins University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Manfred Stolte

University of Erlangen-Nuremberg

View shared research outputs
Researchain Logo
Decentralizing Knowledge