Peter Strehlke
Schering AG
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Featured researches published by Peter Strehlke.
Proceedings of the National Academy of Sciences of the United States of America | 2004
Heike Schäcke; Arndt Schottelius; Wolf-Dietrich Döcke; Peter Strehlke; Stefan Jaroch; Norbert Schmees; Hartmut Rehwinkel; Hartwig Hennekes; Khusru Asadullah
Glucocorticoids (GCs) are the most commonly used antiinflammatory and immunosuppressive drugs. Their outstanding therapeutic effects, however, are often accompanied by severe and sometimes irreversible side effects. For this reason, one goal of research in the GC field is the development of new drugs, which show a reduced side-effect profile while maintaining the antiinflammatory and immunosuppressive properties of classical GCs. GCs affect gene expression by both transactivation and transrepression mechanisms. The antiinflammatory effects are mediated to a major extent via transrepression, while many side effects are due to transactivation. Our aim has been to identify ligands of the GC receptor (GR), which preferentially induce transrepression with little or no transactivating activity. Here we describe a nonsteroidal selective GR-agonist, ZK 216348, which shows a significant dissociation between transrepression and transactivation both in vitro and in vivo. In a murine model of skin inflammation, ZK 216348 showed antiinflammatory activity comparable to prednisolone for both systemic and topical application. A markedly superior side-effect profile was found with regard to increases in blood glucose, spleen involution, and, to a lesser extent, skin atrophy; however, adrenocorticotropic hormone suppression was similar for both compounds. Based on these findings, ZK 216348 should have a lower risk, e.g., for induction of diabetes mellitus. The selective GR agonists therefore represent a promising previously undescribed class of drug candidates with an improved therapeutic index compared to classical GCs. Moreover, they are useful tool compounds for further investigating the mechanisms of GR-mediated effects.
Tetrahedron Letters | 1996
Rolf Bohlmann; Peter Strehlke
Abstract Wittig reaction of aromatic and heteroaromatic 1-acylimidazoles, 1-acyl-1,2,4-triazoles, and 1-acylbenzimidazoles with acceptor-stabilized phosphoranes was found to be a convenient method for the preparation of the E isomers of 1-vinylazoles.
Chemische Berichte | 1973
Helmut Vorbrüggen; Peter Strehlke
Archive | 1998
Manfred Lehmann; Klaus Schöllkopf; Peter Strehlke; Nikolaus Heinrich; Karl-Heinrich Fritzemeier; Hans-Peter Muhn; Rolf Krattenmacher
La Revue du praticien | 2003
Norbert Schmees; Manfred Lehmann; Hartmut Rehwinkel; Peter Strehlke; Stefan Jaroch; Heike Schäcke; Arndt Schottelius
Archive | 1999
Manfred Lehmann; Konrad Krolikiewicz; Werner Skuballa; Peter Strehlke; Frank Kalkbrenner; Roland Ekerdt; Claudia Giesen
Archive | 1989
Peter Strehlke; Rolf Bohlmann; David Henderson; Yukishige Nishino
Archive | 1989
Peter Strehlke; Rolf Bohlmann; David Dr. Henderson; Yukishige Nishino
Archive | 1989
Peter Strehlke; Rolf Bohlmann; David Henderson
Archive | 1989
Peter Strehlke; Rolf Bohlmann; David Dr. Henderson; Yukishige Nishino