Peter Stutz

Eine neue Cyclolestersynthese zum Aufbau von Ergot-Peptidalkaloiden 82. Mitt. über Mutterkornalkaloide

Starting from acylated dipeptides of the general formula G the so-called cyclol esters D are stereospecifically formed in good yields after treatment with a base in polar aprotic solvents. These compounds D are key intermediates for the synthesis of ergot alkaloids of the peptide type. Extension of the scope of this reaction i.e. cyclisation of corresponding acylated dipeptides, the terminal proline being replaced by another amino acid bearing a primary nitrogen atom, could not be verified.