Petra Rach
Schering AG
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Publication
Featured researches published by Petra Rach.
Steroids | 1992
Andreas Steinmeyer; Günter Neef; Gerald Kirsch; Katica Schwarz; Petra Rach; Martin Haberey; Ruth Thieroff-Ekerdt
8(14)a-Homocalcitriol was synthesized and tested for its biologic activities. It exhibited a vitamin D agonist activity profile. The compound was bound to the pig intestinal receptor with an affinity slightly less than calcitriol, showed the same potency in inducing HL 60 cell differentiation and inhibition of keratinocyte proliferation as calcitriol, and was found to be approximately 10-fold less potent in inducing hypercalcemia and hypercalciuria after a single injection in normal rats.
Skin Pharmacology and Physiology | 1992
M. Bräutigam; H. Hübner; Petra Rach; Ruth Thieroff-Ekerdt
Topical application of calcitriol or its analogs is a new approach for treating psoriasis, but may be limited by systemic calcitropic effects. Calcipotriol (MC 903) is a novel calcitriol analog with low calcitropic potency after systemic application. To compare the topical potency of calcitriol and calcipotriol we applied the two drugs on the right flanks of hairless rats for 10 days. In concentrations of 0.001-0.01 g/100 ml (ethanol) the two drugs are equally effective in inducing changes in the horny layer of the skin (increase in the amount of horny material that is able to be desquamated). This can be interpreted as a stimulation of terminal keratinocyte differentiation. However, only calcitriol caused a significant rise in the serum calcium concentration. In conclusion, calcitriol and calcipotriol seem to be equally effective after topical application on the skin of hairless rats, but calcipotriol has a much lower systemic calcium liability.
Archive | 1993
Günter Neef; Gerald Kirsch; Andreas Stein-Eyer; Katica Schwarz; Matthias Dr. Bräutigam; Ruth Thieroff-Ekerdt; Petra Rach
Archive | 1991
Günter Neef; Gerald Kirsch; Andreas Steinmeyer; Katica Schwarz; Matthias Dr. Bräutigam; Rith Dr. Thieroff-Ekerdt; Petra Rach
Archive | 1990
Gerald Kirsch; Günter Neef; Katicia Schwarz; Matthias Dr. Bräutigam; Ruth Thieroff-Ekerdt; Petra Rach
Archive | 1991
Günter Neef; Gerald Kirsch; Andreas Steinmeyer; Katica Schwarz; Matthias Dr. Bräutigam; Ruth Thieroff-Ekerdt; Petra Rach
Archive | 1990
Gerald Kirsch; Günter Neef; Katica Schwarz; Matthias Dr. Bräutigam; Ruth Dr Thieroff-Eckerdt; Petra Rach
Archive | 1992
Gerald Kirsch; Guenter Neef; Ruth Thieroff-Ekerdt; Martin Haberey; Petra Rach
Archive | 1990
Christopher G. Earnshaw; Gerald Kirsch; Petra Rach; Ruth Thieroff-Ekerdt; Michael Dr. Töpert
Archive | 1990
Christopher Earnshaw; Gerald Kirsch; Petra Rach; Ruth Thieroff-Ekerdt; Michael Dr. Töpert