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Dive into the research topics where Petra Rach is active.

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Featured researches published by Petra Rach.


Steroids | 1992

Synthesis and biological activities of 8(14)a-homocalcitriol

Andreas Steinmeyer; Günter Neef; Gerald Kirsch; Katica Schwarz; Petra Rach; Martin Haberey; Ruth Thieroff-Ekerdt

8(14)a-Homocalcitriol was synthesized and tested for its biologic activities. It exhibited a vitamin D agonist activity profile. The compound was bound to the pig intestinal receptor with an affinity slightly less than calcitriol, showed the same potency in inducing HL 60 cell differentiation and inhibition of keratinocyte proliferation as calcitriol, and was found to be approximately 10-fold less potent in inducing hypercalcemia and hypercalciuria after a single injection in normal rats.


Skin Pharmacology and Physiology | 1992

Effects of Calcipotriol (MC 903) and Calcitriol after Topical Application on the Skin of Hairless Rats

M. Bräutigam; H. Hübner; Petra Rach; Ruth Thieroff-Ekerdt

Topical application of calcitriol or its analogs is a new approach for treating psoriasis, but may be limited by systemic calcitropic effects. Calcipotriol (MC 903) is a novel calcitriol analog with low calcitropic potency after systemic application. To compare the topical potency of calcitriol and calcipotriol we applied the two drugs on the right flanks of hairless rats for 10 days. In concentrations of 0.001-0.01 g/100 ml (ethanol) the two drugs are equally effective in inducing changes in the horny layer of the skin (increase in the amount of horny material that is able to be desquamated). This can be interpreted as a stimulation of terminal keratinocyte differentiation. However, only calcitriol caused a significant rise in the serum calcium concentration. In conclusion, calcitriol and calcipotriol seem to be equally effective after topical application on the skin of hairless rats, but calcipotriol has a much lower systemic calcium liability.


Archive | 1993

Side-chain homologous vitamin d derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents

Günter Neef; Gerald Kirsch; Andreas Stein-Eyer; Katica Schwarz; Matthias Dr. Bräutigam; Ruth Thieroff-Ekerdt; Petra Rach


Archive | 1991

24-Oxa derivatives in the vitamin D series

Günter Neef; Gerald Kirsch; Andreas Steinmeyer; Katica Schwarz; Matthias Dr. Bräutigam; Rith Dr. Thieroff-Ekerdt; Petra Rach


Archive | 1990

24-homo vitamin D derivatives, process for their production and pharmaceutical preparations obtained therefrom

Gerald Kirsch; Günter Neef; Katicia Schwarz; Matthias Dr. Bräutigam; Ruth Thieroff-Ekerdt; Petra Rach


Archive | 1991

Side chain homologes of vitamin D derivatives, process for their preparation, pharmaceutical compositions containing them and their use as medicines

Günter Neef; Gerald Kirsch; Andreas Steinmeyer; Katica Schwarz; Matthias Dr. Bräutigam; Ruth Thieroff-Ekerdt; Petra Rach


Archive | 1990

24-D-homo-vitamin D-derivatives, a process for their production, pharmaceutical compositions containing them and their use as medicines

Gerald Kirsch; Günter Neef; Katica Schwarz; Matthias Dr. Bräutigam; Ruth Dr Thieroff-Eckerdt; Petra Rach


Archive | 1992

New 24-benzyl-vitamin D derivs. as hypercalcaemic agents - used to treat hyperproliferative disorders e.g. psoriasis or tumours

Gerald Kirsch; Guenter Neef; Ruth Thieroff-Ekerdt; Martin Haberey; Petra Rach


Archive | 1990

Hydroxyalkane carboxylic acid derivatives and their production

Christopher G. Earnshaw; Gerald Kirsch; Petra Rach; Ruth Thieroff-Ekerdt; Michael Dr. Töpert


Archive | 1990

Hydroxyalkane carboxylic acid derivates, their manufacture and use

Christopher Earnshaw; Gerald Kirsch; Petra Rach; Ruth Thieroff-Ekerdt; Michael Dr. Töpert

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