Ph. Arquint

Integrated blood-gas sensor for pO2, pCO2 and pH

Note: 99 Reference SAMLAB-ARTICLE-1993-001 Record created on 2009-05-12, modified on 2016-08-08

Organic membranes for miniaturized electrochemical sensors: Fabrication of a combined pO2, pCO2 and pH sensor

Note: 104 Reference SAMLAB-ARTICLE-1994-001doi:10.1016/0022-0728(94)87070-5 Record created on 2009-05-12, modified on 2016-08-08

Combined Blood Gas Sensor for pO2, pCO2 and pH

A miniaturized chemical analysis system for extracorporeal monitoring of blood pO2, pCO2 and pH is presented, combining a silicon-based sensor chip and an integrated flow-through channel. Classical electrochemical sensing principles are used, realized in a planar form. The sensor is fabricated entirely on wafer level using IC-compatible processes. By integrating a flow-through channel directly on chip, the sample size and the reagent consumption are drastically reduced. The device characterization has been performed in aqueous solutions, blood intended for transfusion and in whole blood. The sensor exhibits an excellent linearity, low drift and a functional lifetime of more than 2 months.

Coulometric nanotitrators with potentiometric endpoint detection

Coulometric nanotitrators are reported and their applications for different types of titrations are described. Detection of the titration endpoints was carried out by a potentiometric method. Precipitation, complex-formation, redox and acid-base nanotitrations were realized. The results show a linear dependence between 10−2 to 10−3 M or less of analyte.