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Dive into the research topics where Philip Charles Levett is active.

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Featured researches published by Philip Charles Levett.


Tetrahedron Letters | 1997

Tandem 1,3-azaprotio cyclotransfer-cycloaddition reactions between ketoximes and divinyl ketone or its equivalents: Lewis acid mediated rate enhancement and control of cycloaddition regioselectivity

Imaad S. Saba; Martyn Frederickson; Ronald Grigg; Peter J. Dunn; Philip Charles Levett

Abstract The tandem 1,3-azaprotio cyclotransfer-cycloaddition reaction between a ketoxime and divinyl ketone or its equivalents [2-chloroethyl vinyl ketone and bis(2-chloroethyl) ketone] affords high yields of substituted 1-aza-7-oxabicyclo[3.2.1]octan-4-ones and 1-aza-8-oxabicylo[3.2.1]octan-4-ones. Addition of zinc bromide results both in rate enhancement and control of cycloaddition regioselectivity affording almost exclusively 1-aza-7-oxabicyclo[3.2.1]octan-4-ones.


Organic Process Research & Development | 2000

The Chemical Development of the Commercial Route to Sildenafil: A Case History

David J. Dale; Peter J. Dunn; Clare Golightly; Michael Leslie Hughes; Philip Charles Levett; Andrew K. Pearce; Patricia M. Searle; Gordon Ward; Albert Shaw Wood


Archive | 1999

Process for preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof

Peter J. Dunn; Philip Charles Levett


Organic Process Research & Development | 2002

The Process Development of a Scaleable Route to the PDE5 Inhibitor UK-357,903

David J. Dale; John Draper; Peter J. Dunn; Michael Leslie Hughes; Farhat Hussain; Philip Charles Levett; Gordon Ward; Albert Shaw Wood


Organic Process Research & Development | 2010

Investigation into the Formation of the Genotoxic Impurity Ethyl Besylate in the Final Step Manufacturing Process of UK-369,003-26, a Novel PDE5 Inhibitor

Yousef Hajikarimian; Steve Yeo; Robert W. Ryan; Philip Charles Levett; Christopher Stoneley; Paul Singh


Archive | 2000

Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof

Keith Michael Devries; Philip Charles Levett; Joanna Teresa Negri; Albert Shaw Wood


Archive | 2001

Novel process for the preparation of pyrazolopyrimidinones

Mark Edward Bunnage; Philip Charles Levett; Nicholas Murray Thomson


Archive | 2003

Process for the preparation of pyrazolopyrimidinones

Mark Edward Bunnage; Philip Charles Levett; Nicholas Murray Thomson


Archive | 2001

Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof

Charlotte Moira Norfor Allerton; Christopher Gordon Barber; Keith Michael Devries; Laurence James Harris; Philip Charles Levett; Joanna Teresa Negri; David James Rawson; Albert Shaw Wood


Archive | 2005

PROCEDE NOUVEAU POUR LA PREPARATION DE PYRAZOLOPYRIMIDINONES

Mark Edward Bunnage; Philip Charles Levett; Nicholas M. Thomson

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