Philip Wickens
Bayer
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Publication
Featured researches published by Philip Wickens.
Journal of Medicinal Chemistry | 2007
Joachim Rudolph; William Esler; Stephen O'connor; Philip Coish; Philip Wickens; Michael Brands; Donald Bierer; Brian T. Bloomquist; Georgiy Bondar; Libing Chen; Chih-Yuan Chuang; Thomas H. Claus; Zahra Fathi; Wenlang Fu; Uday Khire; James A. Kristie; Xiao-Gao Liu; Derek Lowe; Andrea Mcclure; Martin Michels; Astrid A. Ortiz; Philip Ramsden; Robert W. Schoenleber; Tatiana Shelekhin; Alexandros Vakalopoulos; Weifeng Tang; Lei Wang; Lin Yi; Stephen J. Gardell; James N. Livingston
The peptide hormone ghrelin is the endogenous ligand for the type 1a growth hormone secretagogue receptor (GHS-R1a) and the only currently known circulating appetite stimulant. GHS-R1a antagonism has therefore been proposed as a potential approach for obesity treatment. More recently, ghrelin has been recognized to also play a role in controlling glucose-induced insulin secretion, which suggests another possible benefit for a GHS-R1a antagonist, namely, the role as an insulin secretagogue with potential value for diabetes treatment. In our laboratories, piperidine-substituted quinazolinone derivatives were identified as a new class of small-molecule GHS-R1a antagonists. Starting from an agonist with poor oral bioavailability, optimization led to potent, selective, and orally bioavailable antagonists. In vivo efficacy evaluation of selected compounds revealed suppression of food intake and body weight reduction as well as glucose-lowering effects mediated by glucose-dependent insulin secretion.
Expert Opinion on Therapeutic Patents | 2006
Philip Coish; Philip Wickens; Timothy B. Lowinger
The nuclear transcription factor NF-κB plays a significant role in the pathogenesis of a variety of diseases. Because of the key role played by the inhibitor of κB kinase (IKK) complex in the activation of NF-κB, coupled with the druggability of kinases as a target class, numerous companies have been pursuing discovery programmes aimed at identifying small molecule inhibitors of these enzymes. This paper reviews the patenting activity associated with these efforts.
Archive | 2002
Philip Coish; Stephen J. O'connor; Philip Wickens; Chengzhi Zhang; Hai-Jun Zhang
Bioorganic & Medicinal Chemistry Letters | 2007
Louis-David Cantin; Steven Magnuson; David E. Gunn; Nicole Barucci; Marina Breuhaus; William Bullock; Jennifer Burke; Thomas Claus; Michelle Daly; Lynn B. DeCarr; Ann Gore-Willse; Helana Hoover-Litty; Ellalahewage Kumarasinghe; Yaxin Li; Sidney X. Liang; James N. Livingston; Timothy B. Lowinger; Margit MacDougall; Herbert Ogutu; Alan Olague; Ronda Ott-Morgan; Robert W. Schoenleber; Adrian Tersteegen; Philip Wickens; Zhonghua Zhang; Jian Zhu; Lei Zhu; Laurel Sweet
Archive | 2002
Derek Lowe; Philip Wickens; Xin Ma; Mingbao Zhang; William Bullock; Philip Coish; Ingo A. Mugge; Andreas Stolle; Ming Wang; Yamin Wang; Chengzhi Zhang; Hai-Jun Zhang; Lei Zhu; Manami Tsutsumi; James N. Livingston
Archive | 2005
Joachim Rudolph; Stephen O'connor; Philip Coish; Philip Wickens; Georgiy Bondar; Chih-Yuan Chuang; Philip Ramsden; Derek Lowe; Donald Bierer; Libing Chen; Wenlang Fu; Uday Khire; Xiao-Gao Liu; Andrea Mcclure; Lei Wang; Lin Yi; William Esler
Archive | 2003
Joachim Rudolph; Louis-David Cantin; Steven Magnuson; William Bullock; Ann-Marie Bullion; Libing Chen; Chih-Yuan Chuang; Sidney X. Liang; Dyuti Majumdar; Herbert Ogutu; Alan Olague; Ning Qi; Philip Wickens
Archive | 2008
Steven Magnuson; Philip Wickens; Zhonghua Zhang; Ning Qi; Xin Ma
Archive | 2003
Philip Wickens; Louis-David Cantin; Chih-Yuan Chuang; Miao Dai; Martin F. Hentemann; Ellalahewage Kumarasinghe; Sidney X. Liang; Derek Lowe; Tatiana Shelekhin; Yamin Wang; Chengzhi Zhang; Hai-Jun Zhang; Qian Zhao
Bioorganic & Medicinal Chemistry Letters | 2007
Philip Wickens; Harold Kluender; Julie A. Dixon; Catherine Brennan; Furahi Achebe; Antonella Bacchiocchi; Don Bankston; Donald Bierer; Michael Brands; Debbie Braun; Melissa S. Brown; Chih-Yuan Chuang; Jacques Dumas; Istvan Enyedy; Gloria Hofilena; Zhenqiu Hong; Tim Housley; Benjamin Jones; Uday Khire; Charles Kreiman; Ellalahewage Kumarasinghe; Timothy B. Lowinger; Ronda Ott-Morgan; Louise Perkins; Barton Phillips; Robert W. Schoenleber; William J. Scott; Ryan Sheeler; Aniko Redman; Xiuying Sun