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Featured researches published by Philipp Neuhaus.


Database | 2016

Portal of medical data models: information infrastructure for medical research and healthcare

Martin Dugas; Philipp Neuhaus; Alexandra Meidt; Justin Doods; Michael Storck; Philipp Bruland; Julian Varghese

Introduction: Information systems are a key success factor for medical research and healthcare. Currently, most of these systems apply heterogeneous and proprietary data models, which impede data exchange and integrated data analysis for scientific purposes. Due to the complexity of medical terminology, the overall number of medical data models is very high. At present, the vast majority of these models are not available to the scientific community. The objective of the Portal of Medical Data Models (MDM, https://medical-data-models.org) is to foster sharing of medical data models. Methods: MDM is a registered European information infrastructure. It provides a multilingual platform for exchange and discussion of data models in medicine, both for medical research and healthcare. The system is developed in collaboration with the University Library of Münster to ensure sustainability. A web front-end enables users to search, view, download and discuss data models. Eleven different export formats are available (ODM, PDF, CDA, CSV, MACRO-XML, REDCap, SQL, SPSS, ADL, R, XLSX). MDM contents were analysed with descriptive statistics. Results: MDM contains 4387 current versions of data models (in total 10 963 versions). 2475 of these models belong to oncology trials. The most common keyword (n = 3826) is ‘Clinical Trial’; most frequent diseases are breast cancer, leukemia, lung and colorectal neoplasms. Most common languages of data elements are English (n = 328 557) and German (n = 68 738). Semantic annotations (UMLS codes) are available for 108 412 data items, 2453 item groups and 35 361 code list items. Overall 335 087 UMLS codes are assigned with 21 847 unique codes. Few UMLS codes are used several thousand times, but there is a long tail of rarely used codes in the frequency distribution. Discussion: Expected benefits of the MDM portal are improved and accelerated design of medical data models by sharing best practice, more standardised data models with semantic annotation and better information exchange between information systems, in particular Electronic Data Capture (EDC) and Electronic Health Records (EHR) systems. Contents of the MDM portal need to be further expanded to reach broad coverage of all relevant medical domains. Database URL: https://medical-data-models.org


BMC Medical Research Methodology | 2016

ODMedit: uniform semantic annotation for data integration in medicine based on a public metadata repository

Martin Dugas; Alexandra Meidt; Philipp Neuhaus; Michael Storck; Julian Varghese

BackgroundThe volume and complexity of patient data – especially in personalised medicine – is steadily increasing, both regarding clinical data and genomic profiles: Typically more than 1,000 items (e.g., laboratory values, vital signs, diagnostic tests etc.) are collected per patient in clinical trials. In oncology hundreds of mutations can potentially be detected for each patient by genomic profiling. Therefore data integration from multiple sources constitutes a key challenge for medical research and healthcare.MethodsSemantic annotation of data elements can facilitate to identify matching data elements in different sources and thereby supports data integration. Millions of different annotations are required due to the semantic richness of patient data. These annotations should be uniform, i.e., two matching data elements shall contain the same annotations. However, large terminologies like SNOMED CT or UMLS don’t provide uniform coding. It is proposed to develop semantic annotations of medical data elements based on a large-scale public metadata repository. To achieve uniform codes, semantic annotations shall be re-used if a matching data element is available in the metadata repository.ResultsA web-based tool called ODMedit (https://odmeditor.uni-muenster.de/) was developed to create data models with uniform semantic annotations. It contains ~800,000 terms with semantic annotations which were derived from ~5,800 models from the portal of medical data models (MDM). The tool was successfully applied to manually annotate 22 forms with 292 data items from CDISC and to update 1,495 data models of the MDM portal.ConclusionUniform manual semantic annotation of data models is feasible in principle, but requires a large-scale collaborative effort due to the semantic richness of patient data. A web-based tool for these annotations is available, which is linked to a public metadata repository.


PLOS ONE | 2018

ODM Data Analysis—A tool for the automatic validation, monitoring and generation of generic descriptive statistics of patient data

Tobias Brix; Philipp Bruland; Saad Sarfraz; Jan Ernsting; Philipp Neuhaus; Michael Storck; Justin Doods; Sonja Ständer; Martin Dugas

Introduction A required step for presenting results of clinical studies is the declaration of participants demographic and baseline characteristics as claimed by the FDAAA 801. The common workflow to accomplish this task is to export the clinical data from the used electronic data capture system and import it into statistical software like SAS software or IBM SPSS. This software requires trained users, who have to implement the analysis individually for each item. These expenditures may become an obstacle for small studies. Objective of this work is to design, implement and evaluate an open source application, called ODM Data Analysis, for the semi-automatic analysis of clinical study data. Methods The system requires clinical data in the CDISC Operational Data Model format. After uploading the file, its syntax and data type conformity of the collected data is validated. The completeness of the study data is determined and basic statistics, including illustrative charts for each item, are generated. Datasets from four clinical studies have been used to evaluate the application’s performance and functionality. Results The system is implemented as an open source web application (available at https://odmanalysis.uni-muenster.de) and also provided as Docker image which enables an easy distribution and installation on local systems. Study data is only stored in the application as long as the calculations are performed which is compliant with data protection endeavors. Analysis times are below half an hour, even for larger studies with over 6000 subjects. Discussion Medical experts have ensured the usefulness of this application to grant an overview of their collected study data for monitoring purposes and to generate descriptive statistics without further user interaction. The semi-automatic analysis has its limitations and cannot replace the complex analysis of statisticians, but it can be used as a starting point for their examination and reporting.


Journal of Medical Systems | 2014

Characterization of Image Transfer Patterns in a Regional Trauma Network

Philipp Neuhaus; Thomas Weber; Martin Dugas; Christian Juhra; Bernhard Breil


medical informatics europe | 2016

Converting ODM Metadata to FHIR Questionnaire Resources.

Justin Doods; Philipp Neuhaus; Martin Dugas


Studies in health technology and informatics | 2011

Adapting usability testing techniques to gather user requirements: an illustrative proposal.

Paule Bellwood; Philipp Neuhaus; Christian Juhra


Studies in health technology and informatics | 2015

Standardized mappings--a framework to combine different semantic mappers into a standardized web-API.

Philipp Neuhaus; Justin Doods; Martin Dugas


Archive | 2011

Pitfalls in image exchange in acute trauma care: lessons learned

Christian Juhra; Anne Kathrin Hermanns; René Hartensuer; Thomas Vordemvenne; Frank Ückert; Thomas Weber; Timo Frett; Philipp Neuhaus; Sebastian Hentsch; Michael J. Raschke


Archive | 2010

Unterstützung der Rettungskette durch telematische Anwendungen im Traumanetzwerk Nord-West

Philipp Neuhaus; Martin Lablans; Christian Juhra; Max Ataian; Thomas Weber; Benno Fritzen; Sebastian Hentsch; Frank Ückert


medical informatics europe | 2018

Compatibility Between Metadata Standards: Import Pipeline of CDISC ODM to the Samply.MDR.

Ann-Kristin Kock-Schoppenhauer; Hannes Ulrich; Stefanie Wagen-Zink; Petra Duhm-Harbeck; Josef Ingenerf; Philipp Neuhaus; Martin Dugas; Philipp Bruland

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Thomas Weber

German Aerospace Center

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Frank Ückert

German Cancer Research Center

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Timo Frett

German Aerospace Center

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