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Dive into the research topics where Philippe Birembaut is active.

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Featured researches published by Philippe Birembaut.


Clinical & Experimental Metastasis | 1997

Induction of membrane-type matrix metalloproteinase 1 (MT1-MMP) expression in human fibroblasts by breast adenocarcinoma cells.

Myriam Polette; Christine Gilles; Véronique Marchand; Motoharu Seiki; Jean-Marie Tournier; Philippe Birembaut

Membrane-type matrix metalloproteinase 1 (MT1-MMP) has been recently described as an activator of proMMP-2 (MMP-2) which is involved in tumor invasion. We have shown by in situ hybridization that MT1-MMP is produced by stromal cells in close contact to preinvasive and invasive tumor cells of breast carcinomas. Of particular interest was the observation that some fibroblasts express this enzyme in focal areas in preinvasive lesions, suggesting that particular tumor cells may stimulate fibroblasts to produce MT1-MMP. We have therefore compared the ability of two different breast cancer cell lines, one non-invasive (MCF7) and one invasive (MDA-MB-231) to stimulate MT1-MMP production in human fibroblasts with consequent proMMP-2-activation. The MDA-MB-231 conditioned medium induced MT1-MMP mRNAs in human fibroblasts and a parallel activation of proMMP-2 whereas MCF7 conditioned medium did not have any effect. These results suggest the existence of soluble factor(s) secreted by invasive or some preinvasive breast tumor cells which stimulate fibroblasts to produce and activate MMPs, and emphasize the cooperation between cancer and stromal cells in tumor invasion.


Archive | 2002

Clinical Aspects of Matrix Metalloproteinases

Béatrice Nawrocki-Raby; Christine Clavel; M Polette; Philippe Birembaut

Tumor metastasis is ultimately responsible for most cancer deaths. Tumor invasion and metastasis represent a multistep process including basement membrane disruption, stromal infiltration, angiogenesis, intravasation and extravasation and invasion of target organs by tumor cells. All these events require degradation and remodeling of the extracellular matrix (ECM) by various proteolytic enzymes. Among these enzymes, matrix metalloproteinases (MMPs) play a key role at various levels. These enzymes are associated with degradation of a broad spectrum of ECM components. MMPs are also implicated in the remodeling the ECM by creating and maintaining a microenvironment that facilitates angiogenesis and growth of tumors. Thus, in the last years, the exploration of MMPs expression has led to a large bunch of studies on their biological activities and their clinical implications.


Archive | 2006

Human Papillomavirus Testing for Primary Cervical Cancer Screening

Véronique Dalstein; Jean-Paul Bory; Olivier Graesslin; Christian Quereux; Philippe Birembaut; Christine Clavel


Archive | 2011

RegulationofCXCL8/IL-8ExpressionbyZonulaOccludens-1 in Human Breast Cancer Cells

Anne Brysse; M Polette; E. Luczka; Walter Hunziker; Philippe Birembaut; Jean-Michel Foidart; Christine Gilles


Archive | 2009

The fragile histidine triad gene regulates epithelial-mesenchymal transition associated with invasion of lung tumor cells.

A. Joannes; Arnaud Bonnomet; M Polette; Christine Gilles; Philippe Birembaut; Béatrice Nawrocki-Raby


Archive | 2009

Implication of Zonula Occludens-1 (ZO-1) in the metastatic progression of mammary epithelial tumor cells.

Anne Brysse; M Polette; S Bindels; Mélanie Mestdagt; Arnaud Bonnomet; Walter Hunziker; Agnès Noël; Philippe Birembaut; Jean-Michel Foidart; Christine Gilles


Archive | 2009

Fhit implication in the control of tumor invasion process

A. Joannes; Arnaud Bonnomet; M Polette; Christine Gilles; Philippe Birembaut; Béatrice Nawrocki-Raby


/data/revues/03389898/20020346/02804085/ | 2008

Actualisation de la conduite à tenir en cas de lésions à papillomavirus humains (HPV)

Christine Clavel; Joël Cucherousset; Jean-Paul Bory; René Gabriel; Christian Quereux; Philippe Birembaut


Archive | 2007

Regulation of CXCL8/IL-8 by Zonula Occludens-1 in human breast cancer cells.

Mélanie Mestdagt; M Polette; S Bindels; Walter Hunziker; M Buendia; Agnès Noël; Philippe Birembaut; Jean-Michel Foidart; Christine Gilles


Archive | 2006

Implication de la transition épithélio-mésenchymateuse dans la progression métastatique des cellules tumorales mammaires.

Christine Gilles; Mélanie Mestdagt; S Bindels; M Polette; Béatrice Nawrocki-Raby; Agnès Noël; Walter Hunziker; Philippe Birembaut; Jean-Michel Foidart

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Béatrice Nawrocki-Raby

University of Reims Champagne-Ardenne

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Jm Tournier

University of Reims Champagne-Ardenne

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Christine Clavel

University of Reims Champagne-Ardenne

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A. Joannes

University of Reims Champagne-Ardenne

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