Philippe Gillard

Induction of labour versus expectant management for large-for-date fetuses: a randomised controlled trial

BACKGROUND Macrosomic fetuses are at increased risk of shoulder dystocia. We aimed to compare induction of labour with expectant management for large-for-date fetuses for prevention of shoulder dystocia and other neonatal and maternal morbidity associated with macrosomia. METHODS We did this pragmatic, randomised controlled trial between Oct 1, 2002, and Jan 1, 2009, in 19 tertiary-care centres in France, Switzerland, and Belgium. Women with singleton fetuses whose estimated weight exceeded the 95th percentile, were randomly assigned (1:1), via computer-generated permuted-block randomisation (block size of four to eight) to receive induction of labour within 3 days between 37(+0) weeks and 38(+6) weeks of gestation, or expectant management. Randomisation was stratified by centre. Participants and caregivers were not masked to group assignment. Our primary outcome was a composite of clinically significant shoulder dystocia, fracture of the clavicle, brachial plexus injury, intracranial haemorrhage, or death. We did analyses by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00190320. FINDINGS We randomly assigned 409 women to the induction group and 413 women to the expectant management group, of whom 407 women and 411 women, respectively, were included in the final analysis. Mean birthweight was 3831 g (SD 324) in the induction group and 4118 g (392) in the expectant group. Induction of labour significantly reduced the risk of shoulder dystocia or associated morbidity (n=8) compared with expectant management (n=25; relative risk [RR] 0·32, 95% CI 0·15-0·71; p=0·004). We recorded no brachial plexus injuries, intracranial haemorrhages, or perinatal deaths. The likelihood of spontaneous vaginal delivery was higher in women in the induction group than in those in the expectant management group (RR 1·14, 95% CI 1·01-1·29). Caesarean delivery and neonatal morbidity did not differ significantly between the groups. INTERPRETATION Induction of labour for suspected large-for-date fetuses is associated with a reduced risk of shoulder dystocia and associated morbidity compared with expectant management. Induction of labour does not increase the risk of caesarean delivery and improves the likelihood of spontaneous vaginal delivery. These benefits should be balanced with the effects of early-term induction of labour. FUNDING Assistance Publique-Hôpitaux de Paris and the University of Geneva.

Indications et prérequis à la réalisation d’une extraction instrumentale : quand, comment et où ?

OBJECTIVE To determine the indications and prerequisites for operative vaginal delivery. METHODS Articles were searched using PubMed and Cochrane library. RESULTS Indications for operative vaginal delivery are non-reassuring fetal status (NP4), no progress from 30minutes of adequate active pushing, maternal exhaustion (NP5), or medical indications to avoid Valsalva (NP5). Operative vaginal delivery (Thierrys spatulas, forceps, and vacuum delivery) before that cervix is fully dilated and fetal head is fully engaged is not recommended (NP4). Obstetricians have to know patient medical record and the fetal head position before performing operative vaginal delivery (NP5). The reliability of transvaginal examination to determine the fetal engagement and intrapartum fetal head position is 88% and 80% respectively (NP2). Transabdominal ultrasound assessment is recommended in cases of doubts about the fetal head position (NP5). Available data are not sufficient to fully contraindicated midpelvic operative delivery. Each case should be considered individually and depending on the skill of the obstetrician (NP5). Obstetricians should be aware that they may wrongly consider the fetus engaged in the midpelvis in 6% of cases, whereas it is not really engaged. Moreover, the presence of factors predictive of failed operative vaginal delivery must contraindicated midpelvic operative vaginal delivery and indicated a cesarean delivery (NP5). In general, midpelvic operative vaginal delivery is not recommended. Routine instrumental delivery in theatre and episiotomy for operative vaginal delivery are not recommended (NP3 and NP4, respectively). CONCLUSIONS Recommendations for operative vaginal delivery should be respected to minimize both fetal and maternal trauma. Obstetricians should anticipate the complications that may occurred following operative vaginal delivery.

Planned caesarean in the interventional radiology cath lab to enable immediate uterine artery embolization for the conservative treatment of placenta accreta.

AIM To evaluate the feasibility and efficacy of routine uterine artery embolization (UAE) immediately after planned caesareans performed in the cath lab for conservative treatment of placenta accreta. MATERIALS AND METHODS A retrospective study included all patients who had a planned caesarean in the cath lab for conservative treatment of placenta accreta at Angers University Hospital, which is a tertiary care centre, from April 2001 to September 2010. Twelve patients underwent UAE immediately after caesarean with the placenta left partially or totally in situ. The success rate of embolization, blood loss, and complications were reported. RESULTS Diagnosis of abnormal placentation was confirmed by caesarean findings in 14 cases. Four patients had a percreta form with bladder invasion. In seven cases blood loss was insignificant and UAE was prophylactic; no secondary haemorrhage was observed in this group. Postpartum haemorrhage occurred in five cases: control of immediate postpartum bleeding by embolization was successful in three and failed in two leading to hysterectomy. In one case uterine necrosis occurred 6 weeks after embolization, requiring a hysterectomy. Delayed complications resulted in hysterectomy and partial bladder resection 3 months after delivery for one of the patients with placenta percreta. CONCLUSION UAE immediately after a caesarean performed in the cath lab is a feasible therapeutic option for conservative treatment of placenta accreta. Advantages include reducing stress and risks associated with transferring women with potentially unstable haemodynamics.

Rupture of an aneurysm of the ovarian artery following delivery and endovascular treatment

We report a case of spontaneous rupture of an ovarian artery aneurysm, 5 days after delivery. Severe abdominal pain justified a computed tomography scan, which revealed a massive retroperitoneal hematoma. Arteriography showed the rupture of an ovarian artery aneurysm that was successfully embolized using microcoils.

Prévention de la prématurité spontanée chez les grossesses gémellaires asymptomatiques

Resume Objectifs Determiner les procedes utiles pour predire et prevenir l’accouchement premature spontane chez les patientes asymptomatiques et enceintes de jumeaux. Methode Recherche bibliographique effectuee par consultation des banques de donnees PubMed, Embase et Cochrane. Resultats La tocographie et le depistage d’une vaginose bacterienne ne permettent pas d’identifier une population a risque d’accouchement premature (respectivement NP2 et NP3). Les donnees actuelles de la litterature sont contradictoires et insuffisantes pour determiner, respectivement, si la recherche de fibronectine fœtale dans les secretions cervico-vaginales et le toucher vaginal sont des facteurs predictifs de l’accouchement premature. Seuls les antecedents obstetricaux (antecedent d’accouchement premature) (NP4) et surtout l’echographie endovaginale (NP2) par la mesure de la longueur cervicale sont des facteurs predictifs de prematurite. Cependant, il n’existe aucune etude ayant montre que l’identification d’un groupe a risque d’accouchement premature par l’echographie endovaginale permettait de diminuer la frequence de celui-ci chez les patientes enceintes de jumeaux et asymptomatiques. Le repos strict, l’utilisation de tocolytiques par voie orale a visee prophylactique, l’administration de progesterone, et le cerclage prophylactique chez les patientes avec ou sans modifications cervicales ne permettent pas de diminuer la prematurite (NP1). Conclusions Les moyens de prevention de l’accouchement premature spontane chez les patientes enceintes de jumeaux et asymptomatiques sont actuellement tres limites.

Évaluation de la balance bénéfice/risque selon l’âge gestationnel pour induire la naissance en cas de grossesse prolongée

OBJECTIVES To attempt to determine for post-term pregnancies the optimal gestational age when the benefit-harm balance is in favor of induction labor in comparison with an expectative management including close monitoring. METHODS Articles were searched using PubMed, Embase and Cochrane library. RESULTS Current literature data are insufficient to demonstrate that routine labor induction is superior, inferior or equivalent to an expectant management to reduce maternal and perinatal mortality and morbidity (EL2). Although it is impossible to determine certainly a gestational age for which the benefit-harm balance is in favor of induction labor, epidemiological data regarding the perinatal mortality suggest that an expectant management is an unreasonable option after 42 completed weeks (EL3). Current data are insufficient to state positively or negatively that routine labor induction is associated significantly to a lower rate of cesarean delivery in comparison with an expectant management (EL2). There is no evidence of a statistically significant difference in the risk of cesarean section between the two policies for women with favorable cervices (Bishop score ≥ 5) (EL2). CONCLUSIONS Induction of labor at 41(+0) to 42(+6)weeks should be proposed to women with uncomplicated post-term pregnancies (EL2). The optimal age gestionnal for induction will depend mainly on maternal characteristics (EL4), but also on womens preferences and organization of maternity cares, after having delivered information regarding the benefits and harms of both labor induction and expectant management (expert opinion). After 42(+0)weeks, expectant management is a possible option (expert opinion). Nevertheless, it may be associated with an increase of risks for the fetus, that must be explained to the patient and be weighed against the possible disadvantages of an induction of labor (expert opinion).

Mode d’accouchement des grossesses gémellaires

The assessment of optimal delivery for twin gestations is complex due to the relatively high frequency of obstetrical complications and to the heterogeneity of delivery management in these conditions. The extern validity of the Anglo-Saxon studies is limited in particular because delivery management of the second twin (approach of external cephalic version) differs from the French one (approach of internal version and/or total breech extraction) in cases of non-vertex second twin. Anglo-Saxon studies suggest that a planned vaginal delivery is associated to an increased risk of neonatal morbidity for second twin compared to first twin at term, in particular in cases of combined vaginal-cesarean birth. To reduce the interval twin-to-twin delivery interval and the number of combined vaginal-cesarean births, in our opinion, one must stop to perform external cephalic version and recommend a routinely active management for the second non-vertex twin delivery. With this active management, there is no evidence to support planned cesarean section for twins. Nevertheless, active management requires training as internal version might be difficult to perform, and therefore it is essential to pursue to teach junior obstetrician these obstetric maneuvers. There is limited role for trial of labor after cesarean delivery in twin gestation with a policy of active management.

Policy of high-dose tranexamic acid for treating postpartum hemorrhage after vaginal delivery.

Abstract Objective: To assess whether a policy of routine administration of high-dose tranexamic acid (TA) at the diagnosis of postpartum hemorrhage (PPH) reduces blood loss after vaginal birth. Methods: This controlled single-center before-and-after study of all women with PPH ≥ 500 ml after vaginal birth took place from January 2011 through March 2012; the control group included those seen from January 2011 through August 2011, and the case patients those from September 2011 through March 2012. Our protocol for the management of PPH was modified effective September 2011 to include administration of high-dose TA (4 g of TA intravenously then 1 g/h for 6 h) once blood loss reached 800 ml. Our primary objective was to assess the efficacy of this policy in reducing blood loss in PPH. Results: Maternal characteristics did not differ between the two groups. Mean estimated blood loss was not significantly lower in the TA group (n = 138) than in the control group (n = 151) (respectively, 915.7 ± 321 ml versus 944.8 ± 313.8 ml; p = 0.47). The difference between pre- and post-delivery hemoglobin levels were lower in the TA group (−2.6 g/dl ± 1.2 versus −2.9 g/dl ± 1.3; p = 0.09), but it was not significant. Postpartum iron sucrose injections were significantly less frequent in the TA than the control group (2.2% versus 9.9%; p < 0.05). Conclusions: A policy of high-dose TA in PPH after vaginal deliveries was not associated with a significant reduction of blood loss.

Apport d’un simulateur d’hystéroscopie virtuelle dans l’apprentissage de la résection hystéroscopique de fibrome

OBJECTIVES Uterine myomas are a frequent pathology affecting 20% of women of reproductive age. Myomas induce abnormal uterine bleeding, pelvic pain and increase the risk of infertility and obstetrical complications. Symptomatic sub-mucosal myomas are classically treated by hysteroscopic resection. Simulation is a method of education and training. It could improve quality and security of cares. The aim of this study is to assess the interest of a hysteroscopic simulator for the resection of myoma by novice surgeons. METHODS Twenty medical students were recruited, in a prospective study, in august 2014. The virtual-reality simulator VirtaMed HystSim™ (VirtaMed AG, Zurich, Switzerland) was used to perform the hysteroscopic training. All students received a short demonstration of myoma resection. The practice consists of a submucous myoma type 0 resection. The procedure and the evaluation were performed before and after a specific training in hysteroscopic resection of sixty minutes long. The main outcome criteria were time for the resection before and after training. The second criteria were fluid quantity used, number of contact between optic and uterine cavity and uterine perforation. RESULTS Twenty students aged from 22 to 24 years were included. The time for the procedure was significantly reduced after training (170s versus 335s, P<0.01). There is the same for fluid quantity used (335 mL versus 717mL, P<0.01) and the number of contact between optic and uterine cavity (0.2 contact versus 3, P=0.012). No perforation occurred in the simulation. CONCLUSION The results suggest that hysteroscopic simulator enhances and facilitates hysteroscopic resection for novice surgeons.