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Philippe Van Rompaey

Ghent University

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Publication

Featured researches published by Philippe Van Rompaey.

Natural Product Letters | 2002

Chemotaxonomic features associated with flavonoids of cannabinoid-free cannabis (Cannabis sativa subsp sativa L.) in relation to hops (Humulus lupulus L.).

Gerd Vanhoenacker; Philippe Van Rompaey; Denis De Keukeleire; Pat Sandra

The major flavonoids present in the leaves and flowers of the cannabinoid-free cannabis (Cannabis sativa subsp. sativa L.) cultivars Felina and Futura are orientin (1), vitexin (2), luteolin-7-O-g-D-glucuronide (3), and apigenin-7-O-g-D-glucuronide (4), while prenylated flavonoids, to which the potent estrogenicity of hops (Humilus lupulus L.) is associated, are absent. The different composition of flavonoids has chemotaxonomic value.

Journal of Medicinal Chemistry | 2003

Modeling the Adenosine Receptors: Comparison of the Binding Domains of A2A Agonists and Antagonists

Soo-Kyung Kim; Zhan-Guo Gao; Philippe Van Rompaey; Ariel S. Gross; Aishe Chen; Serge Van Calenbergh; Kenneth A. Jacobson

Journal of Medicinal Chemistry | 2001

Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.

Kenneth A. Jacobson; Zhan-Guo Gao; Aishe Chen; Dov Barak; Soon-Ai Kim; Kyeong Lee; Andreas Link; Philippe Van Rompaey; Serge Van Calenbergh; Bruce T. Liang

Bioorganic & Medicinal Chemistry | 2004

Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position

Michihiro Ohno; Zhan-Guo Gao; Philippe Van Rompaey; Susanna Tchilibon; Soo-Kyung Kim; Brian A Harris; Ariel S. Gross; Heng T. Duong; Serge Van Calenbergh; Kenneth A. Jacobson

Bioorganic & Medicinal Chemistry Letters | 2003

Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

Veerle Vanheusden; Philippe Van Rompaey; Hélène Munier-Lehmann; Sylvie Pochet; Piet Herdewijn; Serge Van Calenbergh

Journal of Medicinal Chemistry | 2006

Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.

Zhan-Guo Gao; Heng T. Duong; Tatiana Sonina; Soo-Kyung Kim; Philippe Van Rompaey; Serge Van Calenbergh; Liaman Mamedova; Hea Ok Kim; Myong Kim; Ae Yil Kim; Bruce T. Liang; Lak Shin Jeong; Kenneth A. Jacobson

Bioorganic & Medicinal Chemistry | 2005

Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety.

Philippe Van Rompaey; Kenneth A. Jacobson; Ariel S. Gross; Zhan-Guo Gao; Serge Van Calenbergh

Bioorganic & Medicinal Chemistry | 2006

Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands

Liesbet Cosyn; Zhan-Guo Gao; Philippe Van Rompaey; Changrui Lu; Kenneth A. Jacobson; Serge Van Calenbergh

European Journal of Organic Chemistry | 2003

Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 '- and 3 '-modified thymidine analogues

Philippe Van Rompaey; Koen Nauwelaerts; Veerle Vanheusden; Jef Rozenski; Hélène Munier-Lehmann; Piet Herdewijn; Serge Van Calenbergh

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2004

Neoceptor concept applied to human A2A and A3 adenosine receptors.

Ka Jacobson; Sk Kim; Michihiro Ohno; Ht Duong; Philippe Van Rompaey; Serge Van Calenbergh; Zg Gao

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Collaboration

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Serge Van Calenbergh

Ghent University

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Kenneth A. Jacobson

National Institutes of Health

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Zhan-Guo Gao

National Institutes of Health

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Piet Herdewijn

Rega Institute for Medical Research

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Aishe Chen

National Institutes of Health

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Ariel S. Gross

National Institutes of Health

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Bruce T. Liang

University of Connecticut Health Center

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Soo-Kyung Kim

California Institute of Technology

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Hélène Munier-Lehmann

Pasteur Institute

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Veerle Vanheusden

Ghent University

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