Phoebe Macrae

Mechanisms of Airway Protection During Chin-Down Swallowing

PURPOSE This study examined the effects of chin-down swallowing on laryngeal vestibule closure. It also investigated the techniques rehabilitative impact, by assessing the stability of effects across multiple trials and aftereffects in neutral swallows on cessation of the technique. METHOD Duration of laryngeal vestibule closure (dLVC) was measured with videofluoroscopy in 16 healthy participants (mean = 33.2 years, 9 men). Participants swallowed 40 times: 5 head-neutral swallows (N1), then 30 chin-down swallows, followed by 5 head-neutral swallows (N2). The first 5 chin-down swallows were categorized as early posture swallows (P1) and the last 5 as late posture swallows (P2). Within-participant comparisons determined the effects of the maneuver on dLVC during and after execution. RESULTS The study found that dLVC increased during chin-down swallows (N1 to P1, p = .018). This increase remained stable throughout 30 repetitions (P1 to P2, p = .994). On return to neutral, dLVC returned to baseline (N1 to N2, p = .875). CONCLUSIONS This study demonstrated increased dLVC during chin-down swallowing, offering a possible mechanism responsible for previously reported reduced aspiration during the technique. As aftereffects were not evident after multiple chin-down swallows, the maneuver appears to offer more compensatory benefit than rehabilitative value for patients with dysphagia.

Intra‐ and inter‐rater reliability for analysis of hyoid displacement measured with sonography

Anterior hyoid displacement is essential for efficient swallowing and is usually investigated with videofluoroscopy. Ultrasound offers a less expensive and noninvasive method of investigation. The present study investigated the viability of a novel method of quantifying hyoid displacement from sonograms using an anatomic reference point, through an evaluation of inter‐ and intra‐rater reliability.

The effect of swallowing treatments on corticobulbar excitability: A review of transcranial magnetic stimulation induced motor evoked potentials

Transcranial magnetic stimulation (TMS) has been used extensively as a method of investigating the corticomotor physiology of many motor tasks, including healthy and disordered swallowing. Changes in excitability of cortical projections to various swallowing muscles have been documented in response to treatments with TMS induced motor evoked potentials (MEPs). These studies have provided valuable insight into CNS response to swallowing impairment, and more importantly, the adaptations associated with functional recovery. However, unique obstacles are presented when investigating corticobulbar neurophysiology associated with the complex task of swallowing. Stringent methodological control and supplementary outcome measures are required to ensure robust and clinically applicable findings. This article offers a tutorial for the researcher who may be considering the use of TMS for investigating changes in cortical excitability associated with various swallowing paradigms. Included is a review of the mechanisms of TMS and what can be measured with this technique, a summary of existing research using MEPs to investigate swallowing, a review of methodological factors that may influence outcomes, and proposed directions for new areas of research.

The Effects of Feedback on Volitional Manipulation of Airway Protection During Swallowing

ABSTRACT Volitional control of autonomic responses, such as heart rate and blood pressure, can be facilitated with the use of augmented feedback. Oropharyngeal swallowing typically includes both volitional and reflexive components, offering a unique opportunity for observing how performance is affected by feedback. Sixteen healthy participants (M age = 29 years, SD = 10 years) completed multiple trials of a novel airway closure technique during swallowing under one of two conditions: no feedback or feedback. The feedback condition included knowledge of performance and knowledge of results. Only the feedback group improved performance across trials (p = .01), with no difference from baseline seen for the no feedback group (p = .66). These results show that airway closure during swallowing can be volitionally manipulated with augmented feedback.

The Sequence of Swallowing Events During the Chin-Down Posture

PURPOSE This study investigated the effect of the chin-down posture on the sequence of swallowing events in healthy adults. METHOD Sixteen healthy participants performed 45 5-ml thin liquid swallows during videofluoroscopy: 5 neutral head position, 30 chin-down posture, and then 10 neutral head position. Eight swallowing events were measured: the time of hyoid burst, bolus head in the pharynx, bolus tail in the pharynx, laryngeal vestibule closure (LVC), upper esophageal sphincter (UES) opening, bolus head in the UES, bolus tail exiting the pharynx, and laryngeal vestibule opening (LVO). RESULTS Our key finding is that LVC was one of the first 3 swallowing events in 69% of neutral swallows and in 78% of chin-down swallows (p = .006). Also, LVO occurred last in 14% of chin-down swallows but never occurred last in the preceding neutral swallows (p ≤ .001). Thus, in chin-down swallows, LVC occurred earlier and LVO occurred later. CONCLUSIONS The chin-down posture may be beneficial for individuals with delayed onset of LVC and reduced duration of the LVC. Future studies are needed to examine this effect in individuals with dysphagia.

The perturbation paradigm modulates error-based learning in a highly automated task: outcomes in swallowing kinematics

Traditional motor learning studies focus on highly goal-oriented, volitional tasks that often do not readily generalize to real-world movements. The goal of this study was to investigate how different perturbation paradigms alter error-based learning outcomes in a highly automated task. Swallowing was perturbed with neck surface electrical stimulation that opposes hyo-laryngeal elevation in 25 healthy adults (30 swallows: 10 preperturbation, 10 perturbation, and 10 postperturbation). The four study conditions were gradual-masked, gradual-unmasked, abrupt-masked, and abrupt-unmasked. Gradual perturbations increasingly intensified overtime, while abrupt perturbations were sustained at the same high intensity. The masked conditions reduced cues about the presence/absence of the perturbation (pre- and postperturbation periods had low stimulation), but unmasked conditions did not (pre- and postperturbation periods had no stimulation). Only hyo-laryngeal range of motion measures had significant outcomes; no timing measure demonstrated learning. Systematic-error reduction occurred only during the abrupt-masked and abrupt-unmasked perturbations. Only the abrupt-masked perturbation caused aftereffects. In this highly automated task, gradual perturbations did not induce learning similarly to findings of some volitional, goal-oriented adaptation task studies. Furthermore, our subtle and brief adjustment of the stimulation paradigm (masked vs. unmasked) determined whether aftereffects were present. This suggests that, in the unmasked group, sensory predictions of a motor plan were quickly and efficiently modified to disengage error-based learning behaviors.

The Relationship Between Submental Surface Electromyography and Hyo-Laryngeal Kinematic Measures of Mendelsohn Maneuver Duration

PURPOSE The Mendelsohn Maneuver (MM) is a commonly prescribed technique that is taught to individuals with dysphagia to improve swallowing ability. Due to cost and safety concerns associated with videofluoroscopy (VFS) use, submental surface electromyography (ssEMG) is commonly used in place of VFS to train the MM in clinical and research settings. However, it is unknown whether ssEMG accurately reflects the prolonged hyo-laryngeal movements required for execution of the MM. The primary goal of this study was to examine the relationship among ssEMG duration, duration of laryngeal vestibule closure, and duration of maximum hyoid elevation during MM performance. METHOD Participants included healthy adults and patients with dysphagia due to stroke. All performed the MM during synchronous ssEMG and VFS recording. RESULTS Significant correlations between ssEMG duration and VFS measures of hyo-laryngeal kinematic durations during MM performance ranged from very weak to moderate. None of the correlations in the group of stroke patients reached statistical significance. CONCLUSION Clinicians and researchers should consider that the MM involves novel hyo-laryngeal kinematics that may be only moderately represented with ssEMG. Thus, there is a risk that these target therapeutic movements are not consistently being trained.

Normative data for pharyngeal pressure generation during saliva, bolus, and effortful saliva swallowing across age and gender

Abstract Pharyngeal manometry provides information on both temporal and amplitude aspects of pressure generation during swallowing. This report provides normative data for three channel pharyngeal manometry on these parameters of pressure generation, providing the normal range of swallowing pressure against which impaired swallowing pressures can be compared. Participants were equally divided into four groups according to age and sex: young females (n = 20), young males (n = 20), older females (n = 20), and older males (n = 20). A discrete-sensor 3-channel manometric catheter measured pharyngeal pressure during three swallowing conditions: saliva swallowing, 10 ml bolus swallowing, and effortful saliva swallowing. Amplitude of peak pressure (mmHg) was recorded for each sensor during the swallow. The latency (ms) between peak pressure at Sensor 1 (approximately BOT) and Sensor 2 (approximately laryngeal additus) and total duration of upper esophageal sphincter relaxation were recorded. Additionally, a pharyngeal composite measure, consisting of an average of the peak amplitude of the two sensors in the pharyngeal segment, was generated to compensate for potential imprecision in recording due to intra-swallow catheter movement. Statistical analyses included derivation of means and 95% confidence intervals across swallowing conditions and participant groups. Clinically, these data provide a comparative database for identification of pathologic pharyngeal functioning in patients with swallowing impairment, and may aid in future studies of swallowing biomechanics.

Effects of chin-up posture on the sequence of swallowing events

Chin‐up posture is frequently used to manage oral dysphagia after head and neck cancer. This prospective study investigates the effects of chin‐ups on the sequence of pharyngeal swallowing events.

Expanding Instrumental Options for Dysphagia Diagnosis and Research: Ultrasound and Manometry

Diagnostic assessment of swallowing in routine clinical practice relies heavily on the long-standing techniques of videofluoroscopic swallowing study (VFSS) and videoendoscopic evaluation of swallowing (VEES). These complementary and sophisticated techniques provide a real-time visualization of biomechanical movements of the structures involved in swallowing and consequent effects on bolus flow. Despite the sophistication of this instrumentation, interpretation relies heavily on subjective clinical judgement and temporal resolution is limited, limitations that may influence patient management. Adjunctive diagnostic assessments may be utilized to compensate for the limitations posed by VFSS and VEES. Ultrasound and pharyngeal manometry do not represent the latest in technological advances, with both emerging in swallowing research over 20 years ago. However, both have resisted integration into routine clinical practice, despite the fact that they offer quantitative metrics of swallowing that are not available using standard techniques. The aim of this review is to present recent research on these two less frequently used modalities in clinical swallowing assessment, discuss potential applications in clinical practice and review supportive data on test-retest reliability, rater reliability and validity. The paper will conclude with a case report that exemplifies the unique contribution of these modalities in executing and revising therapeutic approaches for a patient with neurogenic dysphagia.