Pierluigi Ballardini
Delta Air Lines
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Featured researches published by Pierluigi Ballardini.
Clinical Drug Investigation | 2009
Pierluigi Ballardini; Guido Margutti; Camillo Aliberti; Roberto Manfredini
Sunitinib is an orally administered multitargeted tyrosine kinase inhibitor that has demonstrated substantial antitumour activity in patients with metastatic renal cell carcinoma. The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia. We report the case of a 69-year-old patient with metastatic renal clear-cell carcinoma, treated with nephrectomy and three lines of therapy (interleukin-2 plus interferon-α2a, vinorelbine plus gemcitabine, and capecitabine), who started a fourth-line therapy with oral sunitinib because of disease progression. At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema. After 2 weeks’ off therapy, a partial reduction in mammary gland enlargement, local pain and erythema was observed. However, re-initiation of sunitinib treatment was followed by bilateral breast enlargement again. The mechanism by which sunitinib induces gynaecomastia is thought to be associated with an unknown direct action on breast hormonal receptors. To the best of our knowledge, this is the first report of an association between sunitinib and gynaecomastia.
Tumori | 2010
Pierluigi Ballardini; Ivan Marri; Guido Margutti; Camillo Aliberti; Giorgio Benea; Roberto Manfredini
Effective and safe systemic treatment for advanced hepatocellular carcinoma (HCC) with severe underlying cirrhosis is not yet available. Sorafenib, an oral multikinase inhibitor, has proved to be effective in the treatment of patients affected by HCC with Child-Pugh class A liver function. For patients with cirrhosis-associated HCC having Child-Pugh class B and C liver function, no systemic treatments of documented efficacy and safety exist. We report a case of metastatic HCC associated with Child-Pugh class B cirrhosis that was treated with low, “metronomic” doses of capecitabine (1000 mg/day continuously). This treatment was effective and well tolerated and the response was maintained for 18 months. Metronomic capecitabine may represent a possible alternative in the treatment of those patients with advanced cirrhosis-associated HCC who cannot be treated with sorafenib. Free full text available at www.tumorionline.it
International Medical Case Reports Journal | 2012
Pierluigi Ballardini; Guido Margutti; Massimo Pedriali; Patrizia Querzoli
Syringoid eccrine carcinoma is a very rare skin tumor. Herein we describe a 72-year-old male patient presenting with a syringoid eccrine carcinoma of the nipple with associated axillary lymph node metastases. Surgery associated with adjuvant radiotherapy was performed. To the best of our knowledge, this is the first case of syringoid eccrine carcinoma of the nipple ever reported.
American Journal of Emergency Medicine | 2008
Pierluigi Ballardini; Elena Incasa; Susanna Gamberini; Marilena Tampieri; Arnaldo Zangirolami; Silvia Marzocchi; Giorgio Benea; Roberto Manfredini
Low back pain with sciatica is one of the most common complaints of patients presenting to the ED, and it is usually managed on an outpatient basis. However, acute lower back pain not always derives from a benign cause. We report here the case of a 63-year-old diabetic man who presented to the ED complaining of acute low back pain with sciatica and fever. The cause was a large paravertebral abscess by Streptococcus milleri, and this was the first presenting sign of an unknown underlying colonic cancer.
Tumori | 2004
Pierluigi Ballardini; Elena Incasa; Antonio Del Noce; Luigi Cavazzini; A. Martoni; Edera Piana
Hamartoma of the spleen, first described by Rokitansky in 1861 under the name of “splenoma”, is a rare benign lesion that is nearly always asymptomatic. Apart from the congenital forms there are also acquired forms of splenoma that are frequently associated with hematological diseases or solid tumors. We describe the case of a man suffering from splenoma who had a spontaneous rupture of the spleen with serious hemoperitoneum a few hours after the start of polychemotherapy for squamous cell lung cancer. The close temporal relationship with the event led us to suspect that the drugs used (cisplatin, vinorelbine and corticosteroids) could have played a causal role. From a review of the literature this seems to be the third case reported of spontaneous rupture of the spleen with hamartoma, and the first with the concomitant occurrence of lung cancer.
International Journal of Dermatology | 2014
Monica Corazza; Sara Minghetti; Alessandro Borghi; Annarosa Virgili; Pierluigi Ballardini
disease involving the urethra. J Dermatol 2005; 32: 210–213. 10 Wechsler H, Spivack LL, Dean AL. Erythroplasia of Queyrat with invasive carcinoma and with coincidental carcinoma in situ of urethra. J Urol 1955; 73: 697–702. 11 Mitsuishi T, Sata T, Iwasaki T, et al. The detection of human papillomavirus 16 DNA in erythroplasia of Queyrat invading the urethra. Br J Dermatol 1998; 138: 188–189. 12 Fujisawa Y, Nakamura Y, Takahashi T, et al. Penile preservation surgery in a case of extramammary Pagets disease involving the glans penis and distal urethra. Dermatol Surg 2008; 34: 823–8831. 13 Bernstein G, Forgaard DM, Miller E. Carcinoma in situ of the glans penis and distal urethra. J Dermatol Surg Oncol 1986; 12: 450–455. 14 Hsu GL, Brock G, Von Heyden B, et al. The distribution of elastic fibrous elements within the human penis. Br J Urol 1994; 73: 566–571. 15 Nash PA, Bihrle R, Gleason PE, et al. Mohs micrographic surgery and distal urethrectomy with immediate urethral reconstruction for glanular carcinoma in situ with significant urethral extension. Urology 1996; 47: 108–110.
in Vivo | 2009
Giammaria Fiorentini; Camillo Aliberti; Alessandro Del Conte; Susanna Rossi; Pierluigi Ballardini; Gina Turrisi; Giorgio Benea
European Journal of Cancer | 2006
A. Martoni; Carmine Pinto; Francesca Di Fabio; G. Lelli; Fabiola Lorena Rojas Llimpe; Anna Lisa Gentile; V. Mutri; Pierluigi Ballardini; S. Giaquinta; Edera Piana
Journal of Clinical Oncology | 2005
A. Martoni; Carmine Pinto; F. Di Fabio; G. Lelli; Annalisa Gentile; F. L. Rojas Llimpe; V. Mutri; Pierluigi Ballardini; S. Giaquinta; Edera Piana
American Journal of Emergency Medicine | 2007
Pierluigi Ballardini; Guido Margutti; Arnaldo Zangirolami; Marilena Tampieri; Elena Incasa; Susanna Gamberini; Roberto Manfredini