Pierre Barbier

Enantiospecificity in allergic contact dermatitis A review and new results in Frullania‐sensitive patients

Allergic contact dermatitis is essentially enantiospceific: sensitization to one enantiomer generally does not imply elicitation to the mirror‐image allergens. Examples from patients allergic to Frullania. and from the literature (usnic acids. 4‐methoxydalbergioes, γ‐methyl‐α‐methylene‐γ‐butyrolactones, frullanolides) are discussed.

Allergic contact dermatitis to various salols (phenyl salicylates)

SummaryPatients sensitive to phenyl salicylate (salol) were patch-tested to several aryl salicylates. The most powerful derivative was p-nitrophenyl salicylate (compound 5). This can be explained by an unusually good interaction with protein (nucleophilic substitution on the carboxyl carbon). All these results were confirmed by experimental sensitization of guinea pigs to salol and cross-reaction to substituted salols. The results are in line with current theory of allergic contact dermatitis, i.e., an in vivo formation of a hapten-protein conjugate.

A one-step synthesis of 2-phenylthio-2-buten-4-olides.

Abstract The title compounds are prepared by the reaction of an α-acetoxy aldehyde with ethyl phenylthioacetate.