Pierre-Olivier Lang

Health benefits of multicomponent training programmes in seniors: a systematic review

The ageing process is intrinsically associated with decline in physical endurance, muscle strength and gait ability and balance, which all contribute to functional disability. Regular physical training, and more particularly multicomponent training (MCT), has demonstrated many health benefits.

Frailty: learnings from the SAFEs cohort study and future perspectives for the research

Even though the efforts in research have detailed further the physiopathology and the dynamics of the frailty process an operational definition of frailty is still far from being unequivocal. Studies carried out from the SAFEs cohort study allowed a pragmatic approach in the identification of the at-risk groups for the lost of independency during the hospital stay and factors influencing their future at short-, mid- and long-term. Based upon these results, we propose to discuss the relevance of the current operational indicators of frailty in order to show that clinical markers or indicators are insufficient to differentiate the frailty process from normal ageing. Finally we give rise to the imperative necessity to detect frailty at a preclinical stage with the help of biological and more particularly inflammatory markers.

Effects of Interval Aerobic Training Program with Recovery bouts on cardiorespiratory and endurance fitness in seniors

Interval aerobic training programs (IATP) improve cardiorespiratory and endurance parameters. They are, however, unsuitable to seniors as frequently associated with occurrence of exhaustion and muscle pain. The purpose of this study was to measure the benefits of an IATP designed with recovery bouts (IATP‐R) in terms of cardiorespiratory and endurance parameters and its acceptability among seniors (≥70 years). Sedentary healthy volunteers were randomly assigned either to IATP‐R or sedentary lifestyle. All participants performed an incremental cycle exercise and 6‐minute walk test (6‐MWT) at baseline and 9.5 weeks later. The first ventilatory threshold (VT1); maximal tolerated power (MTP); peak of oxygen uptake (VO2peak); maximal heart rate (HRmax); and distance walked at 6‐MWT were thus measured. IATP‐R consisted of 19 sessions of 30‐minute (6 × 4‐min at VT1 + 1‐minute at 40% of VT1) cycling exercise over 9.5 weeks. With an adherence rate of 94.7% without any significant adverse events, 9.5 weeks of IATP‐R, compared to controls, enhanced endurance (VT1: +18.3 vs −4.6%; HR at baseline VT1: −5.9 vs +0.2%) and cardiorespiratory parameters (VO2peak: +14.1 vs −2.7%; HRmax: +1.6 vs −1.7%; MTP: +19.2 vs −2.3%). The walk distance at the 6‐MWT was also significantly lengthened (+11.6 vs. −3.1%). While these findings resulted from an interim analysis planned when 30 volunteers were enrolled in both groups, IATP‐R appeared as effective, safe, and applicable among sedentary healthy seniors. These characteristics are decisive for exercise training prescription and adherence.

Bleeding Risk under Oral Factor Xa Inhibitors: Meta-analysis of the randomized comparison with Vitamin K Antagonists and Meta-Regression analysis

Background: Randomized trials have shown that oral direct factor Xa inhibitors (ODIXa) offer potential advantages over vitamin K antagonists (VKAs). It is however unclear whether the magnitude of their benefi t is similar at the current recommended doses.

Malabsorption des cobalamines alimentaires : in ou out ? Une étiologie controversée des carences symptomatiques en vitamine B12 chez l’adulte

Jusque dans les annees 1990, les etiologies des carences en vitamine B12 (cobalamine) chez l’adulte etaient representees principalement par la maladie de Biermer et les malabsorptions [1]. Grâce aux progres realises, au cours de ces 25 dernieres annees, dans la comprehension du metabolisme de la vitamine B12, de nouveaux concepts physiopathologiques ont emerge, notamment un nouveau concept, [...]

L’adaptation en français des critères STOPP/START.v2

IntroductionLes effets indesirables (EI) lies aux medicaments representent actuellement une problematique majeure de sante publique dans la population âgee [1, 2]. Les principaux facteurs de risque des EI sont la polymedication et la prescription medicamenteuse inappropriee [3]. Toutes deux ont des effets negatifs sur la sante et la qualite de vie, et augmentent le risque de iatrogenie et l’utilisation des ressources de sante [4, 5] et ce d’autant plus qu’elles concernent [...]