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Dive into the research topics where Pierre-Yves Dakas is active.

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Featured researches published by Pierre-Yves Dakas.


Chemistry: A European Journal | 2009

Divergent Syntheses of Resorcylic Acid Lactones: L‐783277, LL‐Z1640‐2, and Hypothemycin

Pierre-Yves Dakas; Rajamalleswaramma Jogireddy; Gaëlle Valot; Sofia Barluenga; Nicolas Winssinger

The resorcylic acid lactones (RAL) are endowed with diverse biological activity ranging from transcription factor modulators (zearalenone and zearalenol) to HSP90 inhibitors (radicicol and pochonin D) and reversible (aigialomycin D) as well as irreversible kinase inhibitors (hypothemycin and other RAL containing a cis-enone). Our interest in broadening the diversity of this family beyond naturally occurring diversity has led us to seek a general approach that could be used to address the entire spectrum of functionalities present within this family. Herein, we present our efforts on accessing macrocycles bearing an alkane, alkene, or epoxide at the benzylic position from a common benzylic sulfide intermediate to access L-783277, LL-Z1640-2, and hypothemycin.


Angewandte Chemie | 2007

Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors

Pierre-Yves Dakas; Sofia Barluenga; Frank Totzke; Ute Zirrgiebel; Nicolas Winssinger


Angewandte Chemie | 2006

Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold†

Sofia Barluenga; Pierre-Yves Dakas; Yoan Ferandin; Laurent Meijer; Nicolas Winssinger


Chemistry: A European Journal | 2009

Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous‐Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases

Rajamalleswaramma Jogireddy; Pierre-Yves Dakas; Gaëlle Valot; Sofia Barluenga; Nicolas Winssinger


Comptes Rendus Chimie | 2008

Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential

Sofia Barluenga; Pierre-Yves Dakas; Mehdi Boulifa; Emilie Moulin; Nicolas Winssinger


ChemInform | 2010

Metathesis Reactions in Solid‐Phase Organic Synthesis

Sofia Barluenga; Pierre-Yves Dakas; Rajamalleswaramma Jogireddy; Gaële Valot; Nicolas Winssinger


Chemistry: A European Journal | 2009

Cover Picture: Divergent Syntheses of Resorcylic Acid Lactones: L‐783277, LL‐Z1640‐2, and Hypothemycin / Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous‐Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases (Chem. Eur. J. 43/2009)

Pierre-Yves Dakas; Rajamalleswaramma Jogireddy; Gaëlle Valot; Sofia Barluenga; Nicolas Winssinger


ChemInform | 2009

High‐Throughput Synthesis of Natural Products

Nicolas Winssinger; Sofia Barluenga; Pierre-Yves Dakas


Synfacts | 2006

Polymer-Supported Synthesis of Aigialomycin D

Sofia Barluenga; Pierre-Yves Dakas; Y. Ferandin; L. Meijer; Nicolas Winssinger

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Gaëlle Valot

University of Strasbourg

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Emilie Moulin

University of Strasbourg

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Laurent Meijer

Centre national de la recherche scientifique

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Mehdi Boulifa

Centre national de la recherche scientifique

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Yoan Ferandin

Centre national de la recherche scientifique

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