Pingda Ren
Genomics Institute of the Novartis Research Foundation
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Publication
Featured researches published by Pingda Ren.
Bioorganic & Medicinal Chemistry Letters | 2008
Guobao Zhang; Pingda Ren; Nathanael S. Gray; Taebo Sim; Yi Liu; Xia Wang; Jianwei Che; Shin Shay Tian; Mark L. Sandberg; Tracy A. Spalding; Russell Romeo; Maya Iskandar; Donald Chow; H. Martin Seidel; Donald S. Karanewsky; Yun He
A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src kinase family. Highly efficient parallel syntheses were devised to prepare analogues for SAR studies. A number of these 4-amino-6-benzimidazole-pyrimidines exhibited single-digit nanomolar IC(50)s against Lck in biochemical and cellular assays. These 4-amino-6-benzimidazole-pyrimidines represent a new class of tyrosine kinase inhibitors.
Bioorganic & Medicinal Chemistry Letters | 2009
Guobao Zhang; Pingda Ren; Nathanael S. Gray; Taebo Sim; Xia Wang; Yi Liu; Jianwei Che; Weitong Dong; Shin-Shay Tian; Mark L. Sandberg; Tracy A. Spalding; Russell Romeo; Maya Iskandar; Zhiliang Wang; H. Martin Seidel; Donald S. Karanewsky; Yun He
A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src-family kinases (SFKs). These type II inhibitors were optimized using a cellular Lck-dependent proliferation assay and are capable of inhibiting Lck at single-digit nanomolar concentrations. This scaffold is likely to serve a valuable template for developing potent inhibitors of a number of SFKs.
Chemistry & Biology | 2006
Barun Okram; Advait Nagle; Francisco Adrian; Christian C. Lee; Pingda Ren; Xia Wang; Taebo Sim; Yongping Xie; Xing Wang; Gang Xia; Glen Spraggon; Markus Warmuth; Yi Liu; Nathanael S. Gray
Chemistry & Biology | 2005
Hendrik Luesch; Tom Yao-Hsiang Wu; Pingda Ren; Nathanael S. Gray; Peter G. Schultz; Frantisek Supek
Journal of Medicinal Chemistry | 2010
Hwan Geun Choi; Pingda Ren; Francisco Adrian; Fangxian Sun; Hyun Soo Lee; Xia Wang; Qiang Ding; Guobao Zhang; Yongping Xie; Jianming Zhang; Yi Liu; Tove Tuntland; Markus Warmuth; Paul W. Manley; Jürgen Mestan; Nathanael S. Gray; Taebo Sim
Archive | 2007
Pingda Ren; Guobao Zhang; Shuli You; Taebo Sim; Nathanael S. Gray; Yongping Xie; Xing Wang; Yun He
Archive | 2004
Pingda Ren; Francisco Adrian; Nathanael S. Gray; Xia Wang
Chemistry & Biology | 2006
Barun Okram; Advait Nagle; Francisco Adrian; Christian C. Lee; Pingda Ren; Xingbo Wang; Taebo Sim; Yongping Xie; Gang Xia; Glen Spraggon; Markus Warmuth; Yi Liu; Nathanael S. Gray
Archive | 2007
Donatella Chianelli; Christopher Cow; Yun He; Songchun Jiang; Xiaolin Li; Xiaodong Liu; Zuosheng Liu; Jon Loren; Valentina Molteni; Juliet Nabakka; Pingda Ren; Taebo Sim; Xiaodong Wang; Shuli You
Archive | 2007
Pamela A. Albaugh; Yun He; Songchun Jiang; Pingda Ren; Xia Wang; Xing Wang; Yongping Xie
