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Dive into the research topics where Pintu Kumar Mandal is active.

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Featured researches published by Pintu Kumar Mandal.


Bioorganic & Medicinal Chemistry Letters | 2010

Substituted hydrazinecarbothioamide as potent antitubercular agents: synthesis and quantitative structure-activity relationship (QSAR).

Supriya Singh; Pintu Kumar Mandal; Nagendra Singh; Anup Kumar Misra; Shubhra Singh; Vinita Chaturvedi; Sudhir Sinha; Anil K. Saxena

A series of novel substituted hydrazinecarbothioamides was synthesized and evaluated for anti-TB activity. Three most active compounds viz. 1, 6 and 12 were found to exhibit minimum inhibitory concentration (MIC) of 0.4 microg/mL, whereas four compounds viz. 3, 5, 10 and 11 showed comparatively lesser activity with MIC value of 0.8 microg/mL against Mycobacterium tuberculosis strain. A highly significant QSAR equation explaining 81.8% variance is described.


RSC Advances | 2014

Copper-catalyzed one-pot synthesis of glycosylated iminocoumarins and 3-triazolyl-2-iminocoumarins

Pintu Kumar Mandal

A general strategy was developed for the synthesis of glycosyl iminocoumarins (5a–x) in a one-pot, copper-catalyzed multicomponent reaction involving a domino reaction of sulfonyl azides, sugar alkynes, and salicylaldehydes via ketenimine intermediate formation. Similarly, glycosyl 3-triazolyl-2-iminocoumarin derivatives (6a–o) have also been synthesized in a one-pot, three component condensation via tandem “CuAAC-aldol-cyclization-dehydration” sequence. In this event, a copper-catalyzed cycloaddition reaction between 2-azidoacetonitrile and sugar alkynes furnished a triazole derivative in situ and activated the neighboring methylene group, inducing an aldol–cyclization–dehydration sequence in the presence of a salicylaldehyde. The yields were very good in all reactions.


Glycoconjugate Journal | 2008

Concise synthesis of the pentasaccharide O-antigen of Escherichia coli O83:K24:H31 present in the Colinfant vaccine.

Pintu Kumar Mandal; Anup Kumar Misra

AbstractA block synthetic approach is presented for the synthesis of the pentasaccharide repeating unit of the O-antigen of E. coli O83:K24:H31 strain, present in the “Colifant” vaccine. The target pentasaccharide has been synthesized by coupling a disaccharide with a trisaccharide in excellent yield. Yields are quite satisfactory in all intermediate steps. A concise synthesis of the pentasaccharide repeating unit of the O-antigen of E. coli O83:K24:H31 strain, present in the COLINFANT vaccine is presented. The target pentasaccharide has been synthesized following a block synthetic strategy by coupling a disaccharide with a trisaccharide in excellent yield.


Journal of Carbohydrate Chemistry | 2008

Catalyst‐free Efficient Synthesis of 3‐Thio‐2‐deoxysugar Derivatives in Water

Pintu Kumar Mandal; Gour Hari Maiti; Anup Kumar Misra

3‐Thio‐ and 3‐dithiocarbamoyl‐2‐deoxy carbohydrate derivatives have been synthesized using water as solvent without using a catalyst. In most of the cases yields obtained were excellent.


RSC Advances | 2017

Recent advances in photoinduced glycosylation: oligosaccharides, glycoconjugates and their synthetic applications

Rekha Sangwan; Pintu Kumar Mandal

Carbohydrates have been demonstrated to perform crucial tasks in biological processes. However, the advancement in carbohydrate research is relatively slow due to the problems associated with the complexity of carbohydrate structures and the lack of general synthetic methods. Considering that the unique process of photoinduced glycosylation is rapidly emerging as a promising tool in carbohydrate chemistry, this academic review inspects the recent evolution in the chemistry of carbohydrates, including mostly synthetic, and to a lesser extent mechanistic aspects, by examining the strategies that apply photoinduced glycosylation in the synthesis of oligosaccharides and glycoconjugates. We have chosen to present several representative examples that illustrate the diverse and advance uses of photoinduced glycosylation in carbohydrate chemistry for the synthesis of oligosaccharides, thiosugars, glycoconjugates and glycoproteins. As simple techniques for obtaining carbohydrate targets, these methods are mild and effective for the construction of glycosidic bonds via photoinduced promoted glycosylation, which is environmentally friendly. We mainly highlight the symbiotic cooperation of photoinduced glycosylation via electron transfer, hydrogen atom transfer and energy transfer with or without photocatalyst for diverse arrays in the field of total synthesis of carbohydrate based vaccines, thiyl radical mediated clustering, chemical biology and material chemistry.


Beilstein Journal of Organic Chemistry | 2014

Synthesis of the pentasaccharide repeating unit of the O-antigen of E. coli O117:K98:H4

Pintu Kumar Mandal

Summary The pentasaccharide repeating unit of the O-antigen of E. coli O117:K98:H4 strain has been synthesized using a combination of sequential glycosylations and [3 + 2] block synthetic strategy from the suitably protected monosaccharide intermediates. Thioglycosides and glycosyl trichloroacetimidate derivatives have been used as glycosyl donors in the glycosylations.


European Journal of Medicinal Chemistry | 2018

HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors

Rekha Sangwan; Remya Rajan; Pintu Kumar Mandal

Even though one is moving towards the success in the discovery of efficient anti-cancer molecules, the drugs used in the treatment of various malignancies are found to possess toxicity and adverse reactivity in the human body that limit their use. The scientists all over the world are engaged in bringing up strategies that aim to develop small molecules that target the abnormal epigenetic factors. The discovery of the role of Histone deacetylases (HDACs) has promised to be a turning point in the treatment of various malignancies. Thus, the invention of potent and safe anticancer therapeutics agents with minimal adverse and side effects are still a major topic of concern and a huge number of research works have been reported in the past few years. This review has been written to discuss on the influence of Histone Deacetylases in cancer malignancies. We have tried to embrace majority of the developments made till date in the field of HDAC and its inhibitors herein. The drugs that are clinically applied, synthesis and SAR study that highlight the chemical groups responsible for evoking the HDAC inhibition and potential of various new classes of HDAC inhibitors (synthetic, hybrid and natural) have also been included.


RSC Advances | 2016

Synthesis of the pentasaccharide moiety of starfish asterosaponin luidiaquinoside and its conformational analysis

Geeta Karki; Harikesh Kumar; Gajendra Singh; Ravi Sankar Ampapathi; Pintu Kumar Mandal

The synthesis of the pentasaccharide moiety of starfish asterosaponin luidiaquinoside as their p-methoxyphenyl (PMP) glycosides was achieved by following a sequential glycosylation strategy using suitably functionalized thioglycoside donors. Sulfuric acid immobilized on silica (H2SO4–silica) was used successfully as a Bronsted acid catalyst to work as a promoter for all glycosylation reactions. A Qui III donor (5) equipped with a neighbouring participating chloroacetyl (CA) group at the 2-position was first coupled with a trisaccharide acceptor (10) to construct the β-(1-4) glycosidic bond. Then the chloroacetyl (CA) group was selectively removed and subsequent glycosylation with a peracetylated D-fucopyranosyl thioglycoside donor gave the desired pentasaccharide. To gain an understanding about the structural properties of these pentasacharides in a biologically relevant environment, NMR studies were carried out in aqueous solution and the restrained molecular dynamics (MD) were carried using the experimental restraints derived from the NMR studies.


Carbohydrate Research | 2015

Synthesis and biotinylation of oligosaccharide fragments of mannosylated and 5-deoxy-5-methylthio-xylofuranosylated lipoarabinomannan from Mycobacterium tuberculosis

Pintu Kumar Mandal; Pratik Rajesh Chheda

The attachment of biotin to a molecule provides a powerful tool in biology. Here, we report an efficient synthesis and biotinylation of mannosylated and 5-deoxy-5-methylthio-xylofuranosylated Lipoarabinomannan from Mycobacterium tuberculosis. Preparation of the oligosaccharides involved the sequential addition of thioglycoside donors with arabinofuranosyl-containing acceptors. Methylthio group was introduced near the end of the synthesis.


Tetrahedron | 2008

Concise synthesis of two pentasaccharides corresponding to the α-chain oligosaccharides of Neisseria gonorrhoeae and Neisseria meningitidis ☆

Pintu Kumar Mandal; Anup Kumar Misra

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Geeta Karki

Central Drug Research Institute

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Rekha Sangwan

Central Drug Research Institute

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Harikesh Kumar

Central Drug Research Institute

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Pratik Rajesh Chheda

Central Drug Research Institute

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Remya Rajan

Central Drug Research Institute

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Anil K. Saxena

Central Drug Research Institute

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Atul Dubey

Central Drug Research Institute

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