Piotr Kaczorowski
Nicolaus Copernicus University in Toruń
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Publication
Featured researches published by Piotr Kaczorowski.
International Journal of Occupational Medicine and Environmental Health | 2009
Elżbieta Piskorska; Iga Hołyńska-Iwan; Piotr Kaczorowski; Julita Soczywko-Ciudzińska; Michał Wiciński; Magdalena Lampka; Piotr Smuszkiewicz; Tomasz Tyrakowski
OBJECTIVES Toluene diisocyanate (TDI) due to its widespread use in industry is one of the most common and well-known causes of occupational asthma and Reactive Airways Dysfunction Syndrome (RADS). In this study the impact of TDI on the electrophysiological properties of the airways wall, particularly on the mechanisms of absorption of sodium ions and chloride ions secretion was evaluated. MATERIALS AND METHODS Isolated rabbit tracheal wall (from outbred stock animals) was mounted in an apparatus for electrophysiological experiments by means of Ussing method and was mechanically stimulated by the jet flux of specified fluid directed onto the mucosal surface of the tissue from a peristaltic pump. The measured parameters were: transepithelial potential difference under control conditions (PD, mV), after mechanical stimulation (dPD or physiological reaction of hyperpolarization, mV) and electric resistance (R, Omega cm2). When TDI (0.035 mM) was added to stimulation fluid, only the immediate reaction was identified and when it was added to incubation fluid and other experimental fluids, the late (post-incubation) reaction was determined. The experiments involving the inhibition of Na+ by amiloride and Cl- by bumetanide were also performed. RESULTS A series of functional tests for 72 pieces of tracheal wall from 36 animals were performed. It has been shown that short-term exposure to TDI significantly changed the course of reactions to mechanical stimulation. Also after incubation in the presence of TDI, the reactions to mechanical stimulation were changed in relation to control conditions. CONCLUSIONS The immediate reaction of the isolated rabbit tracheal wall after exposure to TDI depends on the duration of exposure and on the physiological condition of the tissue in respect of sodium and chloride ion transport.
Folia Biologica-krakow | 2017
Piotr Kaczorowski; Elżbieta Piskorska; Dorota Olszewska-Słonina; Grzegorz Grześk
The present study contains observations and recording images of the snail foot during spontaneous rectilinear motion on a horizontal glass sheet. Most of the analyzed parameters of snail movement and the folding of the foot epithelium showed linear correlations and varied according to strength. Snail velocity is strongly associated with the foot wave frequency and with the shift of the animal per one wave. This confirms the efficiency of the epithelium folding effect in the foot wave.
Folia Biologica | 2006
Tomasz Tyrakowski; Iga Hołyńska; Magdalena Lampka; Piotr Kaczorowski
An important electrophysiological variable--the transepithelial potential difference reflects the electrogenic transepithelial ion currents, which are produced and modified by ion transport processes in polarized cells of epithelium. These processes result from coordinated function of transporters in apical and basolateral cell membranes and have been observed in all epithelial tissues studied so far. The experiments were performed on isolated specimens of snail foot. In the experiments, the baseline transepithelial electrical potential difference--PD, changes of transepithelial difference during mechanical stimulation--dPD and the transepithelial resistance were measured with an Ussing apparatus. A total of 60 samples of foot ventral surface of 28 snails were studied. The transepithelial electrical potential difference of isolated foot ranged from -6.0 to 10.0 mV under different experimental conditions. Mechanical stimulation of foot ventral surface caused changes of electrogenic ion transport, observed as transient hyperpolarization (electrical potential difference became more positive). When the transepithelial electrical potential difference decreased during stimulation, the reaction was described as depolarization. When amiloride and bumetanide were added to the stimulating fluid so that the sodium and chloride ion transport pathways were inhibited, prolonged depolarization occurred. Under the influence of different stimuli: mechanical (gentle rinsing), chemical (changes of ion concentrations) and pharmacological (application of ion inhibitors), transient changes of potential difference (dPD) were evoked, ranging from about -0.7 to almost 2.0 mV. Changes in transepithelial potential difference of the pedal surface of the snails foot related to these physiological stimuli are probably involved in the locomotion of the animal and are under control of the part of the nervous system in which tachykinin related peptides (TRP) act as transmitters.
Folia Biologica | 2010
Piotr Kaczorowski; Monika Stevesandt; A. Kempczyński; Iwona Trojanowska; Piotr Smuszkiewicz; Magdalena Lampka; Ewa Kopczyńska; Tomasz Tyrakowski
Pharmacological Reports | 2006
Piotr Smuszkiewicz; Leon Drobnik; Jan Mieszkowski; Artur Konikowski; Iga Hołyńska; Piotr Kaczorowski; Tomasz Tyrakowski
Pharmacological Reports | 2005
Tomasz Tyrakowski; Piotr Smuszkiewicz; Drobnik L; Marzec M; Młodzik-Danielewicz N; Lelińska A; Piotr Kaczorowski
Endokrynologia Polska | 2006
Magdalena Lampka; Roman Junik; Anna Nowicka; Hanna Kardymowicz; Piotr Kaczorowski; Tomasz Tyrakowski
Folia Biologica | 2012
Tomasz Tyrakowski; Piotr Kaczorowski; Pawłowicz W; Ziółkowski M; Piotr Smuszkiewicz; Iwona Trojanowska; Marszałek A; Zebrowska M; Lutowska M; Ewa Kopczyńska; Magdalena Lampka; Hołyńska-Iwan I; Piskorska E
Pharmacological Reports | 2006
Tomasz Tyrakowski; Młodzik-Danielewicz N; Kurek W; Szaflarska-Popławska A; Czerwionka-Szaflarska M; Kapała A; Kopczyńska E; Hołyńska I; Piotr Kaczorowski
Forensic Science International | 2005
Ewa Wolska; Natalia Młodzik Danielewicz; Piotr Kaczorowski; Karol Śliwka; Tomasz Tyrakowski