Pl. A. Plattner

Enniatin, ein neues, gegen Mykobakterien wirksames Antibiotikum

From the mycelium ofFusarium orthoceras App. et Wr. var.enniatinum n. v. we have isolated in crystalline form a new antibiotic substance called Enniatin. The chemical and biological characteristics of this substance are described. Enniatin is especially activein vitro against several mycobacteria.

Über die Chemie des Enniatins

Judging by the physical and chemical properties and “bacterial spectra”, the antibiotic substance, Enniatin, previously isolated from a strain ofFusarium by the authors, appears to be identical with that which was recently reported byCook et al. derived from another strain and designated by them as Lateritiin-I, although the reported empirical formulæ differ. Numerous physical and chemical characteristics of Enniatin and its degradation products are given, and, further, two relatedFusarium antibiotics, here designated as Enniatin B and C, are briefly described.

Über Lyco-marasmin, den Welkstoff ausFusarium lycopersici Sacc

The effect of the wilt producing substance, lycomarasmine, isolated from cultures ofFus. lycopersici Sacc., is shown in three pictures. On hydrolysis lycomarasmine yields glycine, aspartic and (probably) pyruvic acid and ammonia. A hypothetical formula is given.

Umlagerung von Azulen in Naphthalin

Azulene (I) is converted into Naphthalene (II) by heating for 48 hours to 330° C.

Synthesis of enniatin B

Die Struktur von Enniatin B, eines antimikrobiellen Wirkstoffes aus Fusarienstämmen (ETH, Zürich), wird durch Synthese als die eines Cyclohexapeptolids bewiesen (vgl. X).

Über die Konstitution des Lactaroviolins

Results of partial hydrogenation support the assumption that lactaroviolin belongs to the azulen group.