Pooja Saluja

One-Pot Synthesis of Biologically Important Spiro-2-amino-4H-pyrans, Spiroacenaphthylenes, and Spirooxindoles Using DBU as a Green and Recyclable Catalyst in Aqueous Medium

Abstract We have reported DBU-catalyzed one-pot synthesis of biologically and pharmacologically important spiropyrans from condensation of malononitrile/ethyl cyanoacetate, 1,3-dicarbonyl compounds, and ninhydrin/acenaphthequinone/istain in good yields. This new protocol employing DBU, which is a green, recyclable, and inexpensive catalyst, offers advantages such as mild reaction conditions, short reaction times, and easy isolation of products. The structures have been confirmed by x-ray analysis. [Supplementary materials are available for this article. Go to the publishers online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] GRAPHICAL ABSTRACT

A facile and green approach for the synthesis of spiro[naphthalene-2,5′-pyrimidine]-4-carbonitrile via a one-pot three-component condensation reaction using DBU as a catalyst

A series of functionalized spiro[naphthalene-2,5′-pyrimidine]-4-carbonitrile derivatives were synthesized using 1,3-dimethylbarbituric acid, aldehydes and cyclohexylidene malononitrile in the presence of DBU. The structures were confirmed by spectral data. X-Ray crystallographic studies of one of the compounds confirmed the structure. The crystal packing shows eight molecules in a single unit cell. The crystal structure also revealed intermolecular and intramolecular hydrogen bonding. Mild reaction conditions, high yields, short reaction time and easy separation are some of the salient features of the present protocol.

Task-specific ionic liquid catalyzed synthesis of novel naphthoquinone–urazole hybrids and evaluation of their antioxidant and in vitro anticancer activity

We have reported the synthesis of naphthoquinone–urazole hybrids via one pot condensation of 2-hydroxynapthalene-1,4-dione, aldehydes and 4-phenylurazole using task specific ionic liquid (bmim[HSO4]). All newly synthesized compounds were screened for in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and anticancer activity against human breast (T47D), colon (HCT-15), lung (NCI-H522), liver (HepG-2) and ovary (PA-1) cancer cell lines. All the naphthoquinone–urazole hybrids showed high DPPH radical scavenging activity, comparable to the standard BHT. Compounds IVf, IVh, IVi and IVj exhibited very good anticancer activity.

An Efficient and Convenient Approach for the Synthesis of Novel Pyrazolo[1,2-a]triazole-triones and Evaluation of their Antimicrobial Activities

A new protocol for the efficient synthesis of novel pyrazolo[1,2-a]triazole-1,3,5-triones has been developed. The synthesis was achieved by reaction of aromatic aldehydes, Meldrum’s acid, and 4-phenylurazole in the presence of a catalytic amount of glacial AcOH at 80°C. The structural assignment has been unambiguously confirmed by X-ray analysis. The present finding provides an environmentally benign, efficient, and promising synthetic strategy for the synthesis of libraries with diversity. These compounds were tested in vitro for their antibacterial activity against four strains, namely Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa and antifungal activity against two fungal strains, namely Aspergillus niger and Aspergillus flavus.

Lanthanum Triflate–Catalyzed Rapid Oxidation of Secondary Alcohols Using Hydrogen Peroxide Urea Adduct (UHP) in Ionic Liquid

Abstract A convenient and efficient protocol for the oxidation of secondary hydroxyl group to ketone using hydrogen peroxide–urea adduct and catalytic (CF3SO3)3La in ionic liquid has been developed. A number of 1,2-diols, α-hydroxyketones, and other aromatic and aliphatic secondary alcohols have been successfully oxidized to the corresponding ketones using this protocol in good yields and short reaction times. [Supplementary materials are available for this article. Go to the publishers online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] GRAPHICAL ABSTRACT

A Facile and Convenient Approach for the Synthesis of Novel Sesamol–Oxazine and Quinoline–Oxazine Hybrids

A series of functionalized sesamol–oxazine and quinoline–oxazine hybrids have been synthesized via one-pot reaction of sesamol/6-hydroxyquinoline, aromatic amines, and methanal. The structures of all the novel compounds were confirmed by spectral data. The structures of the synthesized hybrids were also confirmed by X-ray crystallographic studies. Mild reaction conditions, operational simplicity, short reaction times, simple workup, and high yields of products are salient features of this methodology.

Expedient Synthesis of Diverse Spirooxindoles via Multicomponent Approach in Presence of Green Catalyst

An efficient, convenient and environmentally benign procedure for the construction of various bioactive spirooxindoles has been developed by condensation reactions of isatins, malononitrile and α-methylene carbonyl compounds/enols in the presence of starch solution as expedient, eco-friendly and biodegradable catalyst at 60 °C. The prominent features of the above protocol are short reaction time, high atom economy, simple work-up, cost-effectiveness, avoidance of toxic chemicals.

Synthesis of Spiro[Indene-2,2′-Naphthalene]-4′-Carbonitriles and Spiro[Naphthalene-2,5′-Pyrimidine]-4-carbonitriles via One-pot Three Component Reaction Using Task Specific Ionic Liquid

A novel and efficient methodology has been developed for synthesizing indane-1,3-dione and pyrimidine based spirocyclic compounds. The synthesis has been achieved via multicomponent reaction of indane-1,3-dione/1.3-dimethylbarbituric acid, variously substituted aromatic aldehydes and cyclohexylidene malononitrile in presence of catalytic amount of TSIL [bmim]OH. Short reaction time, high yields and use of non-chromatographic purification techniques are some of the advantages of this methodology.