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Featured researches published by Povl Krogsgaard-Larsen.


Cell Biology and Toxicology | 1992

Pharmacological and functional characterization of excitatory amino acid mediated cytotoxicity in cerebral cortical neurons

Arne Schousboe; Aase Frandsen; Povl Krogsgaard-Larsen

The cytotoxic action of the excitatory amino acids (EAAs) glutamate, N-methyl- D-aspartate (NMDA), quisqualate (QA), kainate (KA) and (RS)-2-amino-3(3-hydoxy-5-methylisoxazol-4-yl) propionate (AMPA) was studied in cerebral cortical neurons in culture. The pharmacological profile of these actions was characterized using the NMDA selective antagonist D-(-)-2-amino-5- phosphonopentanoate (APV) and the non-NMDA selective antagonists 6.7- dinitroquinoxaline-2,3-dione (DNQX), 2-amino-3[3-(carboxymethoxy)-5- methylisoxazol-4-yl]-propionate (AMOA) and 2-amino-3-[2-(3-hydroxy-5- methylisoxazol-4-yl)methyl-3-methyl-3-oxoisoxazolin-4-yl] propionate (AMNH). The role of intracellular Ca++ homeostasis and cGMP production for development of EAA mediated cytotoxicity was assessed by measurements of changes in [Ca++]i using the flourescent Ca++ chelator Fluo-3 and in cGMP concentrations using a conventional radioimmune assay. It was found that glutamate toxicity involves both NMDA and non-NMDA receptor activation and that aberrations in Ca++ homeostasis brought about by Ca++ influx and/or liberation of Ca++ from internal stores aare important for development of toxicity. The drug dantrolene which prevents release of Ca++ from such stores can prevent toxicity induced by glutamate, NMDA and QA completely but has no effect on KA and AMPA toxicity. Changes in cGMP levels appear to play a role for development of glutamate, NMDA and KA toxicity but does not seem to be involved in that triggered by QA and AMPA.


Nature | 1979

Partial agonists for brain GABA/benzodiazepine receptor complex

Claus Braestrup; Mogens Brøndsted Nielsen; Povl Krogsgaard-Larsen; Erik Falch


Archive | 1978

ISOXAZOLO(5,4-C)PYRIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Povl Krogsgaard-Larsen


Archive | 1994

5-arylisoxazol-4-yl-substituted 2-amino carboxylic acid compounds

Lenz Sibylle Moltzen; Erik Falch; Klaus Peter Bogeso; Povl Krogsgaard-Larsen


Archive | 1997

3-Alkoxyisoxazol-4-yl-substituted 2-amino carboxylic acid compounds

Benny Bang-Andersen; Klaus Peter Bogeso; Povl Krogsgaard-Larsen; Lenz Sibylle Moltzen


Archive | 1996

4-aminotetrahydrobenzisoxazole or -isothiazole compounds

Erik Falch; Jens Kristian Perregaard; Arne Schousboe; Povl Krogsgaard-Larsen; Bente Frolund; Sibylle Moltzen Lenz


Archive | 1989

4,5,6,7-Tetrahydroisothiazolo (4,5-c) pyridine derivatives

Erik Falch; Povl Krogsgaard-Larsen; Henrik Pedersen


Archive | 1984

Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems

Erik Falch; Povl Krogsgaard-Larsen; Per Sauerberg; A. Christensen; Jens-Jørgen Larsen


Archive | 1984

Tetrahydroisoxazolo(4,5-c)pyridine derivatives and preparation thereof

Erik Falch; A. Christensen; Povl Krogsgaard-Larsen; Jens-Jørgen Larsen; Per Sauerberg


Archive | 1995

Carbamoyloxy amine compounds

Erik Falch; Ivan Mikkelsen; Povl Krogsgaard-Larsen

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Erik Falch

University of Copenhagen

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Erik Falch

University of Copenhagen

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