Prabhakar Kondaji Jadhav

Copper-catalyzed general CN and CO bond cross-coupling with arylboronic acid

General catalytic Cu(OAc)2/TEMPO in air or Cu(OAc)2/O2 systems for the Cue5f8N and Cue5f8O cross-coupling reactions with arylboronic acid have been discovered. N- and O-vinylation have also been demonstrated.

Synthesis of C2-symmetric HIV-1 protease inhibitors from D-mannitol

Abstract Synthesis of C2-symmetric HIV-1 protease inhibitors from D-mannitol is described.

The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors.

Cyclic urea SD146, a potent HIV protease inhibitor bearing a flat resistance profile, possessed poor solubility and bioavailability, which precluded further development of the compound. In an effort to improve upon the pharmacokinetic profile of the compound, several analogs modified at the P1/P1 residues were prepared and evaluated. Several of those compounds displayed significant improvement of physical properties.