Pradyumna Agasthi

TCT-594 Difference in Neointimal Coverage between First Generation versus Second Generation Drug Eluting Stents using Optical Coherence tomography: A Meta-Analysis.

RESULTS L-ISR group had more frequently heterogeneous intima and less frequently homogeneous than E-ISR group (96.0% vs. 77.1% and 4.0% vs. 22.9%, p<0.01). L-ISR group had more frequently TCFA, neovascularization and macrophage findings than E-ISR group (28.0% vs. 2.9%, p<0.01; 54.2% vs. 11.4%, p<0.01; 72.0% vs. 25.7%, p<0.01), whereas PLIA detected in L-ISR group were lower in E-ISR group (6.4% vs. 19.0%, p1⁄40.01). Thrombus and intimal disruption were not significant different between the 2 groups.

TCT-427 Comparison of Neointimal Coverage Patterns between Biodegradable Vascular Stents and Drug Eluting Stents using Optical Coherence tomography: A Meta-Analysis

METHODS The RAI (Registro Absorb Italiano) Registry is an investigator-driven, prospective registry that included consecutive patients treated with Absorb BRS (ABBOTT Vascular, Santa Clara, CA). Small vessel population included patients in which all the treated lesions had a reference vessel diameter (RVD) 2.75 mm at quantitative coronary analysis including patients with very small vessels (RVD 2.25 mm).

TCT-504 Comparison of Computed Tomography derived Fractional Flow Reserve to invasive Fractional Flow Reserve in Diagnosis of Functional Coronary Stenosis: A Meta-Analysis

METHODS CTA using a 320-row multidetector CT scanner was performed in 321 consecutive patients with suspected CAD. Plain abdominal CT scanning at the umbilical level was also performed to measure visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas. To assess visceral fat accumulation, VAT/SAT (V/S) ratios were calculated. The severity of coronary artery stenosis was assessed on the basis of CTA. Significant stenosis was defined as 50% diameter stenosis. The CT-SXscore was calculated in patients with 1 significant stenoses. Patients were also divided into four groups based on SAT and VAT area median values.

SLEEP APNEA RISK AND LETHAL VENTRICULAR ARRHYTHMIAS IN CONGESTIVE HEART FAILURE PATIENTS WITH IMPLANTABLE CARDIOVERTER DEFIBRILLATORS

Although implantable cardioverter defibrillator (ICD) insertion for primary prevention of sudden cardiac death from lethal ventricular arrhythmias (LVA) is expensive, up to 60% of heart failure patients with ICDs implanted according to current guidelines do not have LVA or device delivered therapy.

CARDIOVASCULAR DISEASE AMONG US ADULT MARIJUANA USERS: NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY, 2011-2012

Marijuana is the most commonly abused drug in US. Studies have shown that cannabinoids up regulates pro-inflammatory cytokines and thrombogenesis which aids progression of atherosclerotic disease and lowers angina threshold. Our aim was to evaluate the association between marijuana and

738: ASSOCIATION BETWEEN SERUM C-REACTIVE PROTEIN LEVELS AND PULMONARY ARTERIAL HYPERTENSION

Learning Objectives: Accumulating evidence implicates the role of systemic inflammation in the pathogenesis of pulmonary arterial hypertension (PAH). C reactive protein (CRP) is an established marker of inflammation that is active in the physiopathology of the vascular wall. It is hypothesized that the proinflammatory properties of CRP contribute to pulmonary vascular remodeling via modulation of the nuclear factor–kappa B pathway. The association between CRP and PAH is unclear. We conducted a meta-analysis to evaluate the relationship between serum CRP levels and PAH. Methods: We searched MEDLINE, CINAHL and COCHRANE databases for studies reporting serum CRP levels in the PAH and non PAH study population. We included case controls, cohort and cross-sectional studies. We calculated the weighted standardized mean difference (SMD) in serum CRP levels between the PAH and control groups. Results: Our search strategy yielded 124 articles. We included eight studies enrolling 861 participants. PAH was diagnosed either by doppler echocardiography (52%) or right heart catheterization (48%). The median age of the PAH group was 55 yr. (IQR 41 61) vs 48 yr. (IQR 34 56) in the control group. The median body mass index in the PAH group was 25.6 kg/m2 (IQR 24.7–26.4) vs 25.9 kg/m2 (IQR 25.1–27.3) in the control group. The unweighted median serum CRP levels in the PAH group were 6.75 mg/l (IQR 3.912.5) vs 3.15 mg/l (IQR 2 – 6.9) in the control group. The SMD of CRP level was 0.75 (95% CI 0.31 – 1.18) p<0.001 comparing the PAH group vs the control group. Conclusions: An elevated serum CRP level is significantly associated with the presence of PAH. Given the significance of elevated CRP levels in PAH, directing further studies in understanding the role or CRP in the etio-pathogenesis of PAH would help determine newer modalities of therapeutic options and prognostic indicators.