Pragnesh Parmar

Status of serum magnesium in type 2 diabetes mellitus with particular reference to serum triacylglycerol levels

UNLABELLED Magnesium (Mg) is the fourth most abundant cation in the body and the second most common intracellular cation. The association between hypomagnesemia and insulin resistance (IR) in diabetes mellitus has been documented earlier. However, we wanted to study whether the extracellular status of magnesium (Mg) could be a biochemical mediator between hypertriacylglycerolemia and diabetes mellitus. AIMS To find out the probable association among HbA1c, triacylglycerol (TG) and magnesium levels - a predictor of vascular complications in T(2)DM. MATERIALS AND METHODS Thirty patients who had attended the diabetic clinics during the period of this study were included. All the samples were analysed for glucose, TG, Mg, and HbA1c. For statistical analysis, SPSS 17 package was used. RESULTS Serum TG (236.67*, 195.06) and HbA1C (9.97*, 8.57) levels were independently compared between the two groups and were significantly high in group A subjects (Mg<1.2mg/dl) as compared to group B subjects (Mg>1.2mg/dl) (*p-value<0.05), respectively. DISCUSSION AND CONCLUSION Hypertriacylglycerolemia was pronounced in type 2 diabetes mellitus patients with accompanying hypomagnesemia. This compared well with that of the glycemic control. Low Mg levels, high TG levels in association with enhanced HbA1c levels could thus serve as a reliable biochemical indicator of insulin status and action without resorting to the usage of criteria for insulin sensitivity and resistance.

Fine needle aspiration cytology of swellings of head and neck region

UNLABELLED Head and neck mass lesions are frequently found in clinical practice. A spectrum of pathological lesions ranging from simple benign lesion to highly malignant manifestation is observed. OBJECTIVES To make clinicopathological correlation of head and neck lesions and to assess the frequency of incidences of different sites, age groups, sex, and distribution among inflammation and neoplastic lesion. MATERIALS AND METHODS A retrospective study was conducted from January 2011 to April 2012. Fine-needle aspiration diagnosis was correlated with details of relevant clinical findings and investigations. Patients aged between 1 and 70 years were included in the study. A total of 200 patients with the swellings of head and neck underwent fine-needle aspiration cytology (FNAC). RESULTS Out of 200 fine-needle aspiration procedures, 52% were of thyroid, 28.50% were of lymph node, 11% from salivary gland, and 4% from soft tissue and miscellaneous swellings. There were 4.5% cases in which diagnosis was not possible. In inflammatory swelling (33%), tuberculous lymph node (42.12%) involvement is common than all other sites with male preponderance (55%). CONCLUSION FNAC is a simple, quick, inexpensive, and minimally invasive technique to diagnose different types of head and neck swellings. It could differentiate the infective process from neoplastic one and avoids unnecessary surgeries. Thus, FNAC can be recommended as a first line of investigation in the diagnosis of head and neck swellings.

Organophosphorus Compound Poisoning- Demographic Profile in Gandhinagar, Gujarat

Organophosphorus Compound Poisoning- Demographic Profile in Gandhinagar, Gujarat Poisoning is an important cause of unnatural death, next to road traffic accidents in India. Incidence of organophosphorus compound poisoning is increasing day by day in western region of India. Demographic profile of organophosphorus compound poisoning cases is very helpful to be aware of current scenario and to implement preventive steps.

Hazards of Free Radicals inVarious Aspects of Health AReview

Hazards of Free Radicals in Various Aspects of Health – A Review The recent growth in the knowledge of free radicals and reactive oxygen species (ROS) in biology is producing a medical revolution that promises a new age of health and disease management. Free radicals are intimately involved in the cellular damage - the common pathway for cancer, aging, and a variety of diseases. Formation of free radicals has been implicated as playing a role in the etiology of cardiovascular disease, cancer, Alzheimer’s disease Parkinson’s disease, and many more. The scientific community has begun to unveil some of the mysteries surrounding this topic, and the media has begun whetting our thirst for knowledge. So that it is a basic need to know about toxic effects of free radicals affecting general health of human body.

Tumoral Calcinosis on Right Knee in 26 Years Old Male: A Rare Case Report

Tumoral Calcinosis on Right Knee in 26 Years Old Male: A Rare Case Report Tumoral calcinosis is a subtype of calcinosis cutis. It is a benign disorder that develops gradually. A 26 years old male patient presented with a painless swelling around the right knee since 1 year. The mineral levels of patient in the form of serum calcium, phosphate and uric acid were normal. Fine Needle Aspiration Cytology (FNAC) followed by excisional biopsy was done and final diagnosis was given as tumoral calcinosis. Although there were other modalities for diagnosis, histopathological examination is the confirmatory and gold standard tool for the final diagnosis.

Study of Dyslipidemic Pattern and Glycosylated Hemoglobin Status in Diabetic Patients

Study of Dyslipidemic Pattern and Glycosylated Hemoglobin Status in Diabetic Patients Background: Diabetes mellitus is a group of metabolic disease causes about 5% of all deaths globally each year. Majority of the diabetic patients also do suffer from dyslipidemia. Aim and objectives: To study glycated hemoglobin levels (HbA1c) and serum lipid levels in diabetes patients and to compare glycated hemoglobin levels with their lipid levels in diabetes patients. Material and methods: The present study was conducted at Gayatri Hospital, Gandhinagar, Gujarat between the periods of January 2011 to January 2012. It was an observational study in which total 60 diabetes patients of indoor as well as outdoor patient department were included. Results: Out of 60 diabetic patients, 63.33% were male, 65% patients were dyslipidemic and 55% had poor glycemic control. Among poor glycemic control patients, 87.88% patients had dyslipidemia. Conclusion: A significant correlation exist between HbA1C and lipid profile in diabetic patients. HbA1C can be used as an indicator of glycemic control as well as a biomarker of lipidemic state in diabetics.