Pranaya Shrestha

Propofol, An Alternative to Amobarbital in Wadas Test in Electro corticography Based Epilepsy Surgery for Determining Dominance of Brain

Annapurna Neurological Institute and Allied Sciences (ANIAS) has been performing ECOG based epilepsy surgery for many years with good results. The semiology of the patient should be concordant with Electro Encephalography (EEG) reading and Magnetic Resonance Imaging (MRI) fi ndings. Determination of dominant hemisphere in terms of language and memory function is important and is done by the WADA test. This test is usually done by short-acting barbiturate (amobarbital) pushed into an internal carotid artery.2,3,7,10,13,14 However Amobarbital is not available in Nepal, so Propofol an anesthetic agent acting on the central nervous system is used.1,6 Its chemical structure is 2,6 diisopropil fenol, it is insoluble in water and is delivered diluting it with equal proportion with normal saline (10 mg/1 ml of solution).