Pranjal H. Mehta

Testosterone and cortisol jointly regulate dominance: Evidence for a dual-hormone hypothesis

Traditional theories propose that testosterone should increase dominance and other status-seeking behaviors, but empirical support has been inconsistent. The present research tested the hypothesis that testosterones effect on dominance depends on cortisol, a glucocorticoid hormone implicated in psychological stress and social avoidance. In the domains of leadership (Study 1, mixed-sex sample) and competition (Study 2, male-only sample), testosterone was positively related to dominance, but only in individuals with low cortisol. In individuals with high cortisol, the relation between testosterone and dominance was blocked (Study 1) or reversed (Study 2). Study 2 further showed that these hormonal effects on dominance were especially likely to occur after social threat (social defeat). The present studies provide the first empirical support for the claim that the neuroendocrine reproductive (HPG) and stress (HPA) axes interact to regulate dominance. Because dominance is related to gaining and maintaining high status positions in social hierarchies, the findings suggest that only when cortisol is low should higher testosterone encourage higher status. When cortisol is high, higher testosterone may actually decrease dominance and in turn motivate lower status.

Testosterone change after losing predicts the decision to compete again.

Testosterone (T) levels can fluctuate after wins and losses, but surprisingly, there are no empirical studies in humans that have tested whether these post-competition T changes predict the social behaviors that follow. The present study examined whether changes in T after losing in a competition predicted who wanted to compete again in a second competition. Sixty-four males provided saliva samples immediately before and 15 min after a rigged one-on-one competition. After the second saliva sample, participants chose whether or not to compete again against the same competitor. Winners did not increase in T relative to losers, but pre-competition cortisol, change in cortisol, and pre-competition T were associated with T changes, especially in losers. Importantly, changes in T predicted decisions to compete again in losers. Losers who increased in T were more likely to choose to compete again than losers who decreased in T. T changes were unrelated to decisions to compete again in winners. These findings provide novel data in humans that T changes after a status loss predict subsequent social behavior. Our discussion focuses on the theoretical implications of these findings for the link between short-term T changes and status-related behaviors.

Neural mechanisms of the testosterone-aggression relation: The role of orbitofrontal cortex

Testosterone plays a role in aggressive behavior, but the mechanisms remain unclear. The present study tested the hypothesis that testosterone influences aggression through the OFC, a region implicated in self-regulation and impulse control. In a decision-making paradigm in which people chose between aggression and monetary reward (the ultimatum game), testosterone was associated with increased aggression following social provocation (rejecting unfair offers). The effect of testosterone on aggression was explained by reduced activity in the medial OFC. The findings suggest that testosterone increases the propensity toward aggression because of reduced activation of the neural circuitry of impulse control and self-regulation.

The Social Endocrinology of Dominance: Basal Testosterone Predicts Cortisol Changes and Behavior Following Victory and Defeat

Past research suggests that individuals high in basal testosterone are motivated to gain high status. The present research extends previous work by examining endocrinological and behavioral consequences of high and low status as a function of basal testosterone. The outcome of a competition--victory versus defeat--was used as a marker of status. In Study 1, high testosterone men who lost in a dog agility competition rose in cortisol, whereas high testosterone men who won dropped in cortisol. Low testosterone mens cortisol changes did not depend on whether they had won or lost. Study 2 replicated this pattern of cortisol changes in women who participated in an experimental laboratory competition, and Study 2 extended the cortisol findings to behavior. Specifically, high testosterone winners chose to repeat the competitive task, whereas high testosterone losers chose to avoid it. In contrast, low testosterone winners and losers did not differ in their task preferences. These results provide novel evidence in humans that basal testosterone predicts cortisol reactivity and behavior following changes in social status. Implications for the social endocrinology of dominance are discussed.

The Mismatch Effect: When Testosterone and Status Are at Odds

Why do some people strive for high status, whereas others actively avoid it? In the present studies, the authors examined the psychological and physiological consequences of a mismatch between baseline testosterone and a persons current level of status. The authors tested this mismatch effect by placing high and low testosterone individuals into high or low status positions using a rigged competition. In Study 1, low testosterone participants reported greater emotional arousal, focused more on their status, and showed worse cognitive functioning in a high status position. High testosterone participants showed this pattern in a low status position. In Study 2, the emotional arousal findings were replicated with heart rate, and the cognitive findings were replicated using a math test. In Study 3, the authors demonstrate that testosterone is a better predictor of behavior than self-report measures of the need for dominance. Discussion focuses on the value of measuring hormones in personality and social psychology.

Testosterone Inhibits Trust but Promotes Reciprocity

The steroid hormone testosterone has been associated with behavior intended to obtain or maintain high social status. Although such behavior is typically characterized as aggressive and competitive, it is clear that high social status is achieved and maintained not only through antisocial behavior but also through prosocial behavior. In the present experiment, we investigated the impact of testosterone administration on trust and reciprocity using a double-blind randomized control design. We found that a single dose of 0.5 mg of testosterone decreased trust but increased generosity when repaying trust. These findings suggest that testosterone may mediate different types of status-seeking behavior. It may increase competitive, potentially aggressive, and antisocial behavior when social challenges and threats (i.e., abuse of trust and betrayal) need to be considered; however, it may promote prosocial behavior in the absence of these threats, when high status and good reputation may be best served by prosocial behavior.

Endogenous testosterone and cortisol jointly influence reactive aggression in women

The dual-hormone hypothesis posits that the effect of testosterone on social behavior is moderated by cortisol. The present study tested this hypothesis with a competitive reactive aggression paradigm in 53 healthy undergraduate women. Salivary cortisol and testosterone were assessed at baseline. Participants were personally insulted and subsequently given the opportunity to retaliate by administering blasts of white noise to the provocateur. Participants were randomly assigned to win or lose the aggressive competition. Basal testosterone positively predicted reactive aggression and state dominance, but only among participants with high concentrations of basal cortisol. The corresponding, reverse pattern was found for state submissiveness. Winners also had higher concentrations of testosterone than losers following the aggressive competition. We discuss the role of heightened reactivity to social provocation as a possible explanation for these effects.

Testosterone and cortisol jointly modulate risk-taking

Recent theories propose that testosterone should be positively related to risk-taking, but empirical support is mixed. Building on the dual-hormone hypothesis, the present research tested whether testosterones role in risk-taking depends on cortisol. Study 1 (N=115) tested this hypothesis in a mixed-sex sample with self and informant reports of risk-taking. Study 2 (N=165) tested this hypothesis in a male-only sample with the Balloon Analog Risk Task, a behavioral measure of risk-taking. Across both studies, there was a positive association between basal testosterone and risk-taking among individuals low in basal cortisol but not individuals high in basal cortisol. This pattern emerged in both males and females and across multiple measures of risk-taking (self reports, informant reports, behavior). These studies provide novel empirical support for the claim that testosterone and cortisol jointly regulate risk-taking. Discussion focuses on putative mechanisms as well as implications for real-world risk-taking behaviors.

When are low testosterone levels advantageous? The moderating role of individual versus intergroup competition

Although theory suggests that testosterone should facilitate competitive performance, empirical evidence has been mixed. The present study tested the hypothesis that testosterones effect on competitive performance depends on whether competition is among individuals (individual competition) or among teams (intergroup competition). Sixty participants (50% women) provided saliva samples and were randomly assigned to complete an analytical reasoning test in individual or intergroup competition. Testosterone was positively related to performance in individual competition, but testosterone was negatively related to performance in intergroup competition. There were no sex differences in performance or in the magnitude of testosterone-performance relationships. These results are consistent with the hypothesis that high testosterone individuals are motivated to gain status (good performance in individual competition), whereas low testosterone individuals are motivated to cooperate with others (good performance in intergroup competition). Theoretical and practical implications are discussed.

The dual-hormone hypothesis: a brief review and future research agenda

The dual-hormone hypothesis posits that testosterones role in status-relevant behavior should depend on concentrations of cortisol, a hormone released in response to physical and psychological stress. This paper (i) reviews evidence for the dual-hormone hypothesis on measures of dominance, aggression, social status, risk-taking, and economic decision-making; (ii) discusses contextual and individual difference moderators of dual-hormone associations with behavior; and (iii) outlines key directions for future research. Together, this review points to promising support for the dual-hormone hypothesis across multiple behavioral domains relevant to the pursuit and maintenance of social status.