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Toxicology Mechanisms and Methods | 2009

Effect of Copper-Hydroquinone Complex on Oxidative Stress-Related Parameters in Human Erythrocytes (In Vitro)

Chandan Sarkar; Prasanta Kumar Mitra; Shyamaprasad Saha; Chittaranjan Nayak; Ranadhir Chakraborty

The effect of in vitro exposure of human erythrocytes to micromolar concentrations of hydroquinone and copper simultaneously on oxidative status-related biochemical parameters was studied. Hydroquinone is a component of cigarette smoke and serum copper level is increased in smokers. Copper forms a complex with hydroquinone and enhances its auto-oxidation to benzoquinone which covalently binds to sulfhydryl group containing compounds like reduced glutathione. In this study, copper increased H2O2 production by hydroquinone. Hydroquinone either alone or in the presence of copper produced a decrease of reduced glutathione level without altering methemoglobin concentration and erythrocyte lipid peroxidation. Catalase inhibition by sodium azide depleted reduced glutathione level further. Copper–hydroquinone complex mediated glutathione depletion in the catalase containing RBC was not decreased by antioxidant, butylated hydroxytoluene. From the known facts and above findings, it is suggested that depletion of reduced glutathione by hydroquinone in the presence of copper in catalase active RBC may be due to the formation of 1, 4 benzoquinone adduct of reduced glutathione and to some extent due to binding of copper to the thiol group of reduced glutathione rather than conversion to oxidized glutathione via reactive oxygen species. Depletion of reduced glutathione by N-ethylmaleimide pretreatment followed by copper-hydroquinone treatment had no effect on methemoglobin level or lipid peroxidation. Furthermore, copper-hydroquinone complex did not increase erythrocyte susceptibility to oxidative stress. This suggests hydroquinone in the presence of copper does not contribute to erythrocyte membrane lipid peroxidation seen in smokers. Criteria for ideal antioxidant supplementation in smokers were suggested.


European Journal of Biotechnology and Bioscience | 2013

Anti-peptic Ulcer Activity of TLC Separated Fractions of Root Extract of Astilbe rivularis in rats

Prasanta Kumar Mitra; Prasenjit Mitra; Tanaya Ghosh


Mintage Journal of Pharmaceutical and Medical Sciences | 2013

ANTI PEPTIC ULCER ACTIVITY OF THE LEAVES OF Amaranthus spinosus L. IN RATS

Prasanta Kumar Mitra; Debiprasad Ghosh; Tanaya Ghosh; Prasenjit Mitra


European Journal of Biotechnology and Bioscience | 2013

3, 4 diHydroxyBenzoic acid Isolated from the Leaves of Ageratum conyzoides L.

Mrinmoy Guria; Prasenjit Mitra; Tanaya Ghosh; Sumanta Gupta; Basudeb Basu; Prasanta Kumar Mitra


Archive | 2014

Anti Gastric Ulcer Activity of Amaranthus spinosus Linn. Leaves in Aspirin Induced Gastric Ulcer in Rats and the Underlying Mechanism

Prasenjit Mitra; Tanaya Ghosh; Prasanta Kumar Mitra


Journal of Pharmacognosy and Phytochemistry | 2013

Isolation and Structural Determination of an Anti Bacterial Constituent from the Leaves of Cassia alata Linn.

Barnali Paul; Prasenjit Mitra; Tanaya Ghosh; Ravinernath Salhan; Takhelmayum Amumachi Singh; Amit Chakrabarti; Sumanta Gupta; Basudeb Basu; Prasanta Kumar Mitra


Journal of Pharmacognosy and Phytochemistry | 2013

Antiulcer Activity of an Isolated Compound (SP-1) from the Seeds of Nirmali (Strychnor potatorum Linn.)

Prasanta Kumar Mitra; Prasenjit Mitra; Tanaya Ghosh


Mintage Journal of Pharmaceutical and Medical Sciences | 2018

ANTI OXIDANT ACTIVITY OF SYZYGIUM CUMINI L. LEAVES: EFFECT OF EXTRACTION SOLVENTS

Prasanta Kumar Mitra; Prasenjit Mitra; Tanaya Ghosh


Mintage Journal of Pharmaceutical and Medical Sciences | 2018

IN VITRO ANTI OXIDANT ACTIVITY OF CHROMATOGRAPHICALLY SEPARATED FRACTIONS FROM SYZYGIUM CUMINI L. LEAVES

Prasanta Kumar Mitra; Prasenjit Mitra; Tanaya Ghosh


Mintage Journal of Pharmaceutical and Medical Sciences | 2018

ANTIOXIDANT POTENTIAL OF GUNDRUK - AN ETHNIC FOOD OF SIKKIM

Prasanta Kumar Mitra; Prasenjit Mitra; Tanaya Ghosh

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Prasenjit Mitra

All India Institute of Medical Sciences

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Tanaya Ghosh

North Bengal Medical College

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Basudeb Basu

University of North Bengal

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Debiprasad Ghosh

North Bengal Medical College

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Sumanta Gupta

University of North Bengal

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Chandan Sarkar

North Bengal Medical College

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