Pratipal Singh

Management of vesicovaginal fistula: An experience of 52 cases with a rationalized algorithm for choosing the transvaginal or transabdominal approach

Purpose: We aim to present our experience for the repair of vesicovaginal fistula (VVF) with special reference to surgical approach. Materials and Methods: From January 1999 to June 2005, 52 VVF patients with mean age of 32 years underwent operative treatment. Fistulas were divided into two groups, simple and complex, depending on site, size, etiology and associated anomalies. Simple VVFs were approached through the vaginal route and complex VVFs via the transabdominal route. Patients were evaluated at two to three weeks initially, three-monthly twice and later depending on symptoms. Results: Thirty-two (61.5%) had simple fistulas and 20 (38.5%) complex fistulas. The most common etiology was obstetric trauma in 31 (59.6%) patients, while the second most common cause was post hysterectomy VVF. Thirty-two (61.5%) patients were managed by transvaginal route, of which 17 had supratrigonal and 15 trigonal fistulas. Twenty (38.5%) patients with complex fistulas were managed by abdominal route. The mean blood loss, postoperative pain and mean hospital stay were shorter in transvaginal repair. Eleven (21.2%) patients required ancillary procedures for various other associated anomalies at the time of fistula repair. Three patients failed repair giving a success rate of 94.2%. At a mean follow-up of three years 48 women were sexually active, of these 10 (19.2%) complained of mild to moderate dyspareunia. Conclusion: Most of the simple fistulas irrespective their locations are easily accessible transvaginally while in complex fistulas we recommend the transabdominal approach. Depending on the clinical context both the approaches achieved comparable success rates.

Laparoscopic Pyeloplasty with Concomitant Pyelolithotomy – Is It an Effective Mode of Treatment?

Introduction: Pelviureteric junction (PUJ) obstruction and concomitant renal calculus disease may coexist. We present our experience with simultaneous laparoscopic pyeloplasty and pyelolithotomy in such patients. Method: 20 patients (20 renal units) underwent transperitoneal laparoscopic pyeloplasty and concomitant pyelolithotomy at our institution. An initial dismembering of the PUJ followed by removal of the calculi with rigid or semi-rigid graspers were done. Calyceal stones were removed with the aid of a flexible cystoscope, rigid/flexible ureteroscope and simultaneous fluoroscopy. The pyeloplasty was subsequently performed in all cases. Result: A median of 2 stones (range 1–12) were recovered from the 20 renal units. Complete stone clearance was possible in 15/20 patients (75%). Three patients underwent subsequent extracorporeal shock-wave lithotripsy and 2 required percutaneous nephrolithotomy. All patients were rendered stone-free at 6 months’ follow-up. Diuretic renography at follow-up revealed improved drainage in 18/20 (90%) patients; 2 patients had an equivocal drainage pattern but their symptoms disappeared. Conclusion: Laparoscopic pyeloplasty with concomitant pyeloplasty is feasible and effective, however patients must be counseled about the possibilities of ancillary procedures to achieve complete stone clearance.

Delayed Presentation in Posterior Urethral Valve : Long-Term Implications and Outcome

OBJECTIVES To analyze the effect of delayed presentation of posterior urethral valves in children. METHODS We divided 194 children with posterior urethral valve (PUV) who underwent surgical ablation into group I (less than 2 years old) and group II (greater than 2 years old) according to age at presentation. We analyzed the data for the effect of various parameters on post-valve fulguration long-term outcomes. RESULTS Groups I and II had 95 and 99 children, respectively. Poor urinary stream or crying during micturition was the most common presenting complaint (96%) in both groups. A total of 32.6% and 81.8% patients had azotaemia at the time of diagnosis in groups I and II, respectively (P <0.001). Mean serum creatinine was 1.68 mg% and 4.1 mg% in groups I and II, respectively (P <0.05). Primary valve ablation was performed in 85.5% patients. After valve ablation, voiding improved in 86.1% and 20.4% patients in groups I and II, respectively (P = 0.001). At a mean follow-up of 9.8 years, 30.5% and 40.8% patients developed renal insufficiency in groups I and II, respectively (P <0.05). Serum creatinine level at 1 year after valve ablation and at presentation was the main prognostic factor for groups I and II, respectively, whereas persistence of VUR and voiding dysfunction after valve ablation reflected poor prognosis for both groups. CONCLUSIONS Patients with PUV presenting after 2 years should be treated with caution because the condition is potentially hazardous and these patients are at a higher risk of developing chronic renal insufficiency on long-term follow-up.

Laparoscopic pyeloplasty: a versatile alternative to open pyeloplasty.

Objective: To report the safety, efficacy and versatility of laparoscopic pyeloplasty (LPP) in treatment of pelviureteric junction obstruction (PUJO). Patients and Methods: From January 2002 to November 2006, 185 patients (186 units; 182 with primary and 4 with secondary PUJO) underwent LPP (transperitoneal approach in 184; retroperitoneal approach in 2). A double J stent was placed antegradely in 121 (68.4%) units, cystoscopically in 50 units (28.2%), and 6 units (3.4%) were stentless. Patients were followed up clinically, with additional diuretic renogram. Results: Surgery was completed laparoscopically in 177 units, and conversion was required in 9 (4.8%) units. Pyeloplasty was dismembered in 143 units, Foley YV plasty in 26 units, and Fenger pyeloplasty in 8 units. The median estimated blood loss, operative time and hospital stay were 50 ml, 180 min and 4 days, respectively. Overall, 18 (9.6%) patients had complications. Improvements in drainage patterns of 167 out of 177 units (94.3%) were shown on a renal scan at a median follow-up of 39 months (range: 3–63 months). Conclusion: LPP is a safe, effective and versatile method for treatment of PUJO, which is applicable to all age groups, even in the presence of secondary stones, crossing vessels and secondary PUJO.

Laparoscopic Radical Nephrectomy: A Journey from T1 to Very Large T2 Tumors

Objectives: To evaluate the feasibility, efficacy and safety of laparoscopic radical nephrectomy (LRN) in T1 and T2 renal tumors. Patients and Methods: From December 1999 to March 2007, a retrospective analysis of 102 patients was done. A thorough preoperative workup was done in all patients. Postoperatively the patients were followed up every 3 months for the first year, 6-monthly for the next 2 years and yearly thereafter. Results: Transperitoneal radical nephrectomy was done in 85 patients, whereas 7 patients had a retroperitoneal surgery. A combined approach of retroperitoneal renal artery clipping followed by transperitoneal nephrectomy was done in 10 patients. 72 patients had clinically T1 tumors and 30 patients were T2 tumors. Mean tumor size was 6.97 cm, mean operative time was 174 min, mean blood loss was 230 ml, mean hospital stay was 4.6 days, and mean incision length was 8 cm. 19 patients had conversion to open surgery. Mean follow-up was 22.6 (range 4–56) months. Overall recurrence-free survival was 88.1%. Conclusions: LRN is a safe and effective treatment for renal tumors with a steep learning curve. Large right-sided T2 tumors can be safely treated with the combined approach. Disease control rates with LRN are satisfactory.

Percutaneous Nephrolithotomy in Ectopically Located Kidneys and in Patients with Musculoskeletal Deformities

Objective: To assess the feasibility, safety and results of percutaneous nephrolithotomy (PNL) in ectopically located kidneys and in patients with musculoskeletal deformities. Patients and Methods: Thirteen such patients underwent PNL between June 2005 and May 2008. Mean stone size was 27.4 mm (16–37 mm). Six patients had severe kyphoscoliosis, 2 patients each had achondroplasia, cross-fused ectopia and pelvic ectopic kidney, and 1 patient had thoracic kidney. All had a preoperative CT scan of the abdomen. Preoperative ultrasound- or CT-guided percutaneous nephrostomy (PCN) was done in 10 patients. Three patients underwent laparoscopic-assisted PNL. All underwent standard PNL. The stone-free rate, complication rate and need for secondary intervention were evaluated. Results: PNL was successfully completed in all. A second ultrasound-guided intraoperative puncture was required in 2 patients. Re-look PNL was required in 1 patient and the same patient later required shock wave lithotripsy for complete stone clearance. The remaining 12 patients (92.3%) were rendered stone-free in a single sitting. Conclusion: PNL is a feasible and effective modality in anomalous kidneys. Preoperative planning with CT and image-guided PCN is helpful in these situations. Laparoscopic-assisted PNL can be safely performed in patients where access to a renal collecting system by fluoroscopy or image-guided assistance (ultrasound or CT scan) is not possible.

Percutaneous nephrolithotomy of a staghorn stone in thoracic ectopic kidney

Abstract:  Congenital thoracic ectopic kidney is a very rare developmental anomaly and the rarest form of all ectopic kidneys. It is usually asymptomatic and discovered incidentally on routine chest radiography. Herein we reported the first case of staghorn stone in a thoracic kidney managed successfully by percutaneous nephrolithotomy.

A comparison of kidney retrieval incisions in laparoscopic transperitoneal donor nephrectomy.

Objective: To compare the modified iliac fossa and Pfannenstiel incisions for retrieving the kidney in laparoscopic transperitoneal donor nephrectomy. Patients and Methods: Two different incisions for retrieving the donor kidney were studied from January 2002 to December 2006. A total of 343 laparoscopic transperitoneal donor nephrectomies were performed. 110 kidneys were removed via our modified iliac fossa incision and 233 kidneys were retrieved using a Pfannenstiel incision. The warm ischemia time, analgesic requirement and hospital stay were compared. Other parameters studied were the length of incisions, total number of incisions (port and retrieval), and complications associated with them. Results: The warm ischemia time (3 vs. 3.5 min), mean hospital stay (3.35 vs. 3.8 days) and analgesic requirement were comparable. The mean length of incisions was 5.8 vs. 7.3 cm, respectively, and this difference was found to be statistically significant. The total number of incisions (port and retrieval) was 4 when the iliac fossa incision was used, whereas it was 5 when the kidney was retrieved using a Pfannenstiel incision. Two patients had bladder injury and 1 patient had bowel injury while making the Pfannenstiel incision. There was less morbidity associated with the iliac fossa incision. Conclusion: The iliac fossa incision had less morbidity whereas the Pfannenstiel incision scored in terms of cosmesis.

Bacillus Calmette-Guerin in the management of superficial bladder cancer

Intravesical Bacillus Calmette-Guérin (BCG) is the mainstay of superficial bladder cancer treatment. We performed a literature search through Medline/Pubmed using key words ‘Bacillus Calmette-Guérin’, ‘intravesical’, ‘bladder neoplasm’ and ‘immunotherapy’ for published data in the English language from 1970 to 2007 to review the current status of intravesical therapy and practice recommendations. The exact mechanism of action of intravesical BCG is yet to be elucidated. However, it appears that it is mediated by the local immune response, mainly through T-helper cell response. It reduces the recurrence rate by an average of 40% and progression by more than 20% in papillary tumors over the patients without BCG therapy. However, progression prevention is seen only in series which have used maintenance therapy at least for one year. It is effective in CIS of bladder with a response rate of more than 40% and prevention of progression in one-fourth patients. Most acceptable dose, induction treatment and maintenance therapy protocols are discussed. However, these are yet to be confirmed in large randomized trials. Intravesical BCG is well tolerated in most of the patients with mild to moderate side-effects in induction therapy; however, most patients do not complete maintenance therapy due to side-effects which is the most common concern at the present time.

Minimal invasive treatment of ureteropelvic junction obstruction in low volume pelvis: A comparative study of endopyelotomy and laparoscopic nondismembered pyeloplasty.

Objective: To evaluate the role of nondismembered laparoscopic pyeloplasty and percutaneous endopyelotomy for ureteropelvic junction obstruction (UPJO) with low volume renal pelvis. Material and Methods: Retrospective acquired data of 34 patients of laparoscopic nondismembered pyeloplasty was compared with 26 patients of UPJO with pelvic volume less than 50 ml undergoing antegrade endopyelotomy and analyzed for clinical parameters, operative outcomes and success of procedures. All patients were followed up clinically and with diuretic renogram at regular intervals. Results: Mean age, renal pelvic volume and preoperative glomerular filtration rate (GFR) was 25 years, 43.6 ml and 42.5 ml/min, respectively in endopyelotomy group and 21 years, 34.4 ml and 39.9 ml/min, respectively in laparoscopic pyeloplasty group. Mean operative time, postoperative analgesic requirement and mean hospital stay was 100min, 250 mg and 4 days, respectively in endopyelotomy group and 210 min, 300 mg and 4 days, respectively in laparoscopic pyeloplasty group. Only operative time was significantly different between two groups (P < 0.05). Mean follow-up was 36 and 39 months and success rates were 91.2% and 88.8% in laparoscopy and endopyelotomy group, respectively (P < 0.05). No significant complication was seen in endopyelotomy group while two patients had hematuria (one requiring blood transfusion) and three had increased drain output for more than 3 days in laparoscopy group. Conclusion: Percutaneous endopyelotomy is associated with significantly less operative time and postoperative complication rate and provides equivalent success in comparison to nondismembered laparoscopic pyeloplasty in patients with UPJO and low volume pelvis. It can be a preferred minimally invasive treatment modality for such patients.