Pravin V. Shinde

Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach.

Synthesis of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives (4a-h) using 1,3-dipolar cycloaddition (click chemistry) reaction of 3-(azidomethyl)-2-chloro-quinoline derivatives (3a-h) with phenyl acetylene in the presence of Cu(I) catalyst has been achieved in very high yield. These molecules were evaluated in vitro for their antifungal and antibacterial activity. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains.

Surfactant catalyzed convenient and greener synthesis of tetrahydrobenzo[a]xanthene-11-ones at ambient temperature

Summary An efficient and greener protocol for the synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one using tetradecyltrimethylammonium bromide (TTAB) at room temperature in water is described.

β-Cyclodextrin-SO3H-catalyzed facile and highly efficient synthesis of 4-thiazolidinones under solvent free conditions

A one-pot, multi-component, green, and highly efficient procedure has been developed for synthesis of 4-thiazolidinones. Use of β-cyclodextrin-SO3H as an eco-friendly and recyclable catalyst resulted in excellent yields under solvent-free conditions. This procedure has the advantages of readily available starting materials, short reaction times, high yields, easy workup, broad substrate scope, and use of an environment-friendly catalyst. The catalyst can be recycled with slight loss of its catalytic activity.Graphical Abstract