Priscilla A. Sturm

The effect of various concentrations of tocopherols and tocopherol mixtures on the oxidative stability of a sample of lard.

A comparison was made of α-, γ-, and δ-tocopherol at various concentrations and a mixture of these tocopherols representing the average tocopherol content of peanut oil on the oxidative stability of lard at 97C. Uptake of oxygen was used to indicate the length of the induction period. The antioxidant effectiveness of the tocopherols was found to increase in the order α, δ, γ. The antioxidant efficiency decreases with increasing concentrations of tocopherols such that addition of any single tocopherol above a concentration of 250 µg/g has little effect on oxidative stability. A mixture equivalent to that of an average peanut oil sample, containing 150 µg/g of α-tocopherol and 250 µg/g of γ-tocopherol and 15 µg/g of δ-tocopherol was found to be no more stable than one containing 250 µg/g of γ-tocopherol alone.

Synthesis of acyclonucleoside phosphonates as antiviral agents against cytomegalovirus

Abstract Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV phosphate and DHPG phosphate have been synthesized and evaluated for antiviral activity against human, murine, and guinea pig strains of cytomegalovirus. The phosphonates showed high activity against all of the strains. They were also evaluated against a DHPG resistant strain of human cytomegalovirus. Although the activity dropped considerably, significant antiviral activity was still evident.

Synthesis of Phosphonic Acid Analogs of Acyclovir (ACV) and Canciclovir (DHPG)

Abstract Isosteric Phosphonic acid analogs of acyclovir and ganciclovir have been synthesized for evaluation for antiviral activity.