Pritom Shah
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Publication
Featured researches published by Pritom Shah.
Bioorganic & Medicinal Chemistry Letters | 2001
Simon J. F. Macdonald; Michael Dennis Dowle; Lee Andrew Harrison; Pritom Shah; Martin R. Johnson; Graham G. A. Inglis; Geoffrey D.E Clarke; Robin Smith; Davina Humphreys; Christopher R. Molloy; Augustin Amour; Mary Dixon; Graham Murkitt; Rosalind E. Godward; Tony Padfield; Tadeusz Skarzynski; Onkar M. P. Singh; K.Abhhilash Kumar; Gill Fleetwood; Simon Teanby Hodgson; George W. Hardy; Harry Finch
The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.
Bioorganic & Medicinal Chemistry Letters | 2001
Simon J. F. Macdonald; Michael Dennis Dowle; Lee Andrew Harrison; Julie E. Spooner; Pritom Shah; Martin R. Johnson; Graham G. A. Inglis; Geoffrey D.E Clarke; David J. Belton; Robin Smith; Christopher R. Molloy; Mary Dixon; Graham Murkitt; Rosalind E. Godward; Tadeusz Skarzynski; Onkar M. P. Singh; K.Abhhilash Kumar; Simon Teanby Hodgson; Edward McDonald; George W. Hardy; Harry Finch
Described are the acylation binding of trans-lactam 1 to porcine pancreatic elastase, the selection of the SO2Me activating group for the lactam N which also confers metabolic stability in hamster liver microsomes, the introduction of aqueous solubility through the piperidine salt 9, the in vivo oral activity of 9 and its bioavailability, and the introduction of 9 as an intracellular neutrophil elastase inhibitor.
Bioorganic & Medicinal Chemistry Letters | 2001
Simon J. F. Macdonald; Michael Dennis Dowle; Lee Andrew Harrison; Julie E. Spooner; Pritom Shah; Martin R. Johnson; Graham G. A. Inglis; Geoffrey D.E Clarke; David J. Belton; Robin Smith; Christopher R. Molloy; Mary Dixon; Graham Murkitt; Rosalind E. Godward; Tadeusz Skarzynski; Onkar M. P. Singh; K.Abhhilash Kumar; Simon Teanby Hodgson; Edward McDonald; George W. Hardy; Harry Finch; Davina Humphreys; Gill Fleetwood
Simon J. F. Macdonald,* Michael D. Dowle, Lee A. Harrison, Julie E. Spooner, Pritom Shah, Martin R. Johnson, Graham G. A. Inglis, Geoffrey D. E. Clarke, David J. Belton, Robin A. Smith, Christopher R. Molloy, Mary Dixon, Graham Murkitt, Rosalind E. Godward, Tadeusz Skarzynski, Onkar M. P. Singh, K. Abhhilash Kumar, Simon T. Hodgson, Edward McDonald, George W. Hardy, Harry Finch, Davina C. Humphreys and Gill Fleetwood
Journal of Medicinal Chemistry | 2002
Simon J. F. Macdonald; Michael Dennis Dowle; Lee Andrew Harrison; Geoffrey D. Clarke; Graham G. A. Inglis; Martin R. Johnson; Pritom Shah; Robin Smith; Augustin Amour; Gill Fleetwood; Davina Humphreys; Christopher R. Molloy; Mary Dixon; Rosalind E. Godward; Alan J. Wonacott; Onkar M. P. Singh; Simon Teanby Hodgson; George William Hardy
Archive | 1997
Michael Dennis Glaxo Wellcome Plc Dowle; Harry Finch; Lee Andrew Glaxo Wellcome Plc Harrison; Graham George Adam Inglis; Martin Redpath Glaxo Wellcome Plc Johnson; Simon John Fawcett Glaxo Wellcome Plc Macdonald; Pritom Shah; Robin Andrew Glaxo Wellcome Plc Smith
Archive | 1991
Barry Clive Ross; David Middlemiss; Colin David Eldred; John Gary Montana; Pritom Shah
Archive | 1991
Barry Clive Ross; David Ian Carter Scopes; Kevin Stuart Cardwell; Colin David Eldred; David Middlemiss; Torquil Iain Maclean Jack; Michael Dennis Dowle; John Gary Montana; Pritom Shah
Archive | 1994
Harry Finch; Pritom Shah; Robin Arthur Ellis Carr
Archive | 1992
Barry Clive Ross; David Middlemiss; David Ian Carter Scopes; Torquil Iain Maclean Jack; Kevin Stuart Cardwell; Michael Dennis Dowle; Colin David Eldred; John Gary Montana; Pritom Shah; Stephen P. Watson
Archive | 1994
Harry Finch; David G. Trist; Aldo Feriani; Giorgio Tarzia; Pritom Shah
