Pu Yuepu

Association between the effects of body mass index on lung volumes among students in Jiangsu Province

Resu l t s : Mean of lung capacity volume (mL), and the ratio of vital lung capacity and BMI (mL/kg) in males were significantly more than females (P < 0.001), also the differences in lung volumes by gender was reported within the 13 cities in Jiangsu Province. Lung capacity (mL) was showed significant positive association with height (r = 0.70, P < 0.001), weight (r = 0.60, P < 0.001) in males and body height in females (r = 0.54, P < 0.001), respectively. The significantly low, moderate positive association was reported in males lung capacity volume (P < 0.001) compare with the negative association in females within the ratio of vital lung capacity and BMI (P < 0.001). BMI, as reported, lowers association values of lung volume.

Lys751GIn polymorphism in ERCC2 gene is associated with lung cancer susceptibility in the Chinese population

Abstract The excision repair cross-complementing group 2 (ERCC2) gene encodes a DNA repair protein, which is absolutely necessary in nucleotide excision repair. A polymorphism in codon 751 that induces a Lys-Gln substitution has been suggested to reduce the DNA repair capacity. Therefore, we conducted a matched case-control study to investigate the role ERCC2 Lys751Gln polymorphism in the development of lung cancer in the Chinese population. The genotype of ERCC2 gene was analyzed by di-allele-specific-amplification with artificially modified primers (diASA-AMP) in 200 original lung cancer cases and 200 controls. The results showed that carriers of Lys/Gln and Gln/Gln genotypes had a 3.32-fold higher risk of lung cancer compared with carriers of Lys/Lys genotype. Furthermore, the mutant genotype of 751 Gln allele was found to be associated with an increased risk in both lung squamous cell carcinoma and lung adenocarcinoma. However, no significant interaction between 751Gln variants and smoking was observe...