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Pui Yee Ng

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Publication

Featured researches published by Pui Yee Ng.

Bioorganic & Medicinal Chemistry Letters | 2018

Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11

Matthew W. Martin; Jennifer Y. Lee; David R. Lancia; Pui Yee Ng; Bingsong Han; Jennifer R. Thomason; Maureen S. Lynes; C. Gary Marshall; Chiara Conti; Alan John Collis; Monica Alvarez Morales; Kshama Doshi; Aleksandra Rudnitskaya; Lili Yao; Xiaozhang Zheng

N-Hydroxy-2-arylisoindoline-4-carboxamides are potent and selective inhibitors of HDAC11. The discovery, synthesis, and structure activity relationships of this novel series of inhibitors are reported. An advanced analog (FT895) displays promising cellular activity and pharmacokinetic properties that make it a useful tool to study the biology of HDAC11 and its potential use as a therapeutic target for oncology and inflammation indications.

Archive | 2016

ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS

Kenneth W. Bair; Nicholas Barczak; Bingsong Han; David Lancia; Cuixian Liu; Matthew W. Martin; Pui Yee Ng; Aleksandra Rudnitskaya; Jennifer R. Thomason; Mary Zablocki; Xiaozhang Zheng

Archive | 2016

3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS

Pui Yee Ng; Heather Davis; Kenneth W. Bair; David S. Millan; Aleksandra Rudnitskaya; Xiaozhang Zheng; Bingsong Han; Nicholas Barczak; David Lancia

Archive | 2017

ÁCIDOS BICÍCLICOS[4,6,0]HIDROXÁMICOS COMO INHIBIDORES DE HDAC

David Lancia; Aleksandra Rudnitskaya; Pui Yee Ng; Xiaozhang Zheng

Archive | 2017

ÁCIDOS [4,5,0] HIDROXÁMICOS 3-ALQUIL-4-AMIDO-BICÍCLICOS COMO INHIBIDORES DE HDAC

Matthew W. Martin; David S. Millan; David Lancia; Aleksandra Rudnitskaya; Heather Davis; Cuixian Liu; Mary Zablocki; Jennifer R. Thomason; Bingsong Han; Pui Yee Ng; Xiaozhang Zheng

Archive | 2017

TETRALINAS DE ÁCIDO 3-ESPIRO-7-HIDROXÁMICO COMO INHIBIDORES DE HDAC

David Lancia; Nicholas Barczak; Xiaozhang Zheng; Bingsong Han; Aleksandra Rudnitskaya; David S. Millan; Kenneth W. Bair; Heather Davis; Pui Yee Ng

Archive | 2017

COMPUESTOS DE a-CINAMIDA Y COMPOSICIONES COMO INHIBIDORES DE HDAC8

Xiaozhang Zheng; Mary Zablocki; Jennifer R. Thomason; Aleksandra Rudnitskaya; Pui Yee Ng; Matthew W. Martin; Cuixian Liu; David Lancia; Bingsong Han; Nicholas Barczak; Kenneth W. Bair

Archive | 2017

ÁCIDOS 3-ALQUIL BICÍCLICOS[4,5,0]HIDROXÁMICOS COMO INHIBIDORES DE HDAC

Matthew W. Martin; David S. Millan; Kenneth W. Bair; David Lancia; Aleksandra Rudnitskaya; Cuixian Liu; Mary Zablocki; Jennifer R. Thomason; Bingsong Han; Pui Yee Ng; Xiaozhang Zheng

Archive | 2017

INHIBIDORES DE HDAC8 BICÍCLICOS FUSIONADOS [6,6]

Kenneth W. Bair; Nicholas Barczak; David Lancia; Aleksandra Rudnitskaya; Cuixian Liu; Mary Zablocki; Jennifer R. Thomason; Bingsong Han; Pui Yee Ng; Xiaozhang Zheng

Archive | 2017

ÁCIDOS HIDROXÁMICOS [4,5,0] 3-ARIL-4-AMIDO-BICÍCLICOS COMO INHIBIDORES DE HDAC

Matthew W. Martin; David S. Millan; David Lancia; Aleksandra Rudnitskaya; Heather Davis; Cuixian Liu; Mary Zablocki; Jennifer R. Thomason; Bingsong Han; Pui Yee Ng; Xiaozhang Zheng

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Collaboration

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Xiaozhang Zheng

Genentech

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Jennifer R. Thomason

Pfizer

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Matthew W. Martin

Amgen

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Stephanos Ioannidis

AstraZeneca

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C. Gary Marshall

Merck

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Alan John Collis

Aventis Pharma

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