Pulak J. Bhuyan

Metallic bismuth and tantalum mediated C-allylation of aldimines with allyl bromide

Abstract A facile method for the synthesis of homoallyl amines using Bi/BU 4 NBr/MeCN and Ta/Bu 4 NBr/THF system has been performed in a regiospecific manner.

“Tertiary amine effect” strategy in the synthesis of novel uracil analogues

Abstract 6-Tertiary amino uracils 1 react with dimethyl acetylenedicarboxylate 2 to give 4,5-dihydropyrrolo[2,3-d]pyrimidine 3 and 4,5,6,7,8-pentahydropyrrolizino[2,3-d]pyrimidine analogues 5 in excellent yields.

Studies on uracils: a facile one-pot synthesis of pyrazolo[3,4-d]pyrimidines

The reaction of 6-hydrazino uracils 1 with isocyanates 2 gave access to an efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidines 3 in excellent yields.

Synthesis of dihydro- and tetrahydroisoxazolo[3',4':3,4]pyrrolo[1,2-a]indoles via intramolecular cycloadditions: a novel class of mitomycin analogues

Abstract A novel class of dihydro- and tetrahydroisoxazolo [3′,4′:3,4]pyrrolo[1,2-a]indoles are synthesized via intramolecular nitrone and nitrile oxide cycloaddition reactions.

Intramolecular 1,3-dipolar cycloaddition reactions in the synthesis of complex annelated quinolines, α-carbolines and coumarins

In this study, we report the synthesis of several novel dihydroisoxazole-, tetrahydroisoxazole- and dihydropyrazole-fused pyrido[2,3-b]quinolines, α-carbolines, and pyrido[2,3-c]coumarins, respectively, from simple precursors and by exploring intramolecular 1,3-dipolar cycloaddition reactions involving nitrile oxides, nitrones, and nitrile imines as 1,3-dipoles.

A novel one-pot three-component reaction for the synthesis of 5-arylamino-pyrrolo[2,3-d]pyrimidines under microwave irradiation

Some novel 5-arylamino-pyrrolo[2,3-d]pyrimidine derivatives were synthesized via microwave-assisted three-component reaction of N,N-dimethyl-6-aminouracil, aryl glyoxal monohydrates and aryl amines. The products were obtained in good to excellent yields (82–91%) using a simple work-up procedure.

Studies on uracils: synthesis of novel pyrido[2,3-d]pyrimidine oxides via ring transformation of isoxazolo[3,4-d]pyrimidine

Abstract The reaction of isoxazolo[3,4- d ]pyrimidine 1 and cyanoolefins 2 in the presence of triethylamine (Et 3 N) as a catalyst afforded an unprecedented one-pot synthesis of biologically important pyrido[2,3- d ]pyrimidine oxides 3 in excellent yields.

Reductive Alkylation of α-Keto Imines Catalyzed by PTSA/FeCl3: Synthesis of Indoles and 2,3′-Biindoles

A simple and efficient method for the synthesis of highly functionalized indoles and biindoles was developed. In the reaction protocol, three components were used in one pot and products were obtained in high yield in an easy workup procedure. The reaction occurred via initial reductive alkylation of α-keto imines, followed by a cyclization process in the presence of PTSA/FeCl3 as catalyst.

An efficient one-pot three-component reaction for the synthesis of novel functionalized pyrano[3,2-c]coumarins catalyzed by Na2CO3 in aqueous medium

An efficient green method for the synthesis of novel functionalized pyrano[3,2-c]coumarins from a one-pot three-component reaction of 4-hydroxycoumarins, dialkylacetylenedicarboxylates and alkyl acetonitriles catalyzed by Na2CO3 in aqueous medium was developed. The pure products were obtained in high yield from a simple work-up procedure.

Studies on uracils: A simple and efficient method for the synthesis of novel pyrimido[4,5-c]pyridazines

Abstract The reaction of 6-hydrazino uracils 1 and acetylenedicarboxylates 2 at room temperature affords tetrahydro-pyrimido[4,5-c]pyridazines 3 in excellent yield.