Punam Paudyal

Diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) by fine needle aspiration cytology.

Sinus histiocytosis with massive lymphadenopathy (Rosai‐Dorfman disease) is a rare benign disease of unknown etiology presenting with massive lymphadenopathy. We report four cases of this disease retrieved from the archives of cytopathology laboratory, BPKIHS, Dharan, Nepal, during the period of January 2002 to October 2007. The cytologic morphology revealed lymphocytes, plasma cells, and single to multinucleated histiocytes with well preserved lymphocytes in their cytoplasm (emperipolesis or lymphophagocytosis). It is concluded that FNAC is a useful and reliable tool for the diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai‐Dorfman disease) and biopsy can be avoided in these patients, thereby reducing patient inconvenience and health care cost. Diagn. Cytopathol. 2008;36:691–695.

Encapsulated papillary carcinoma of the breast: A rare entity

Introduction: Encapsulated papillary carcinoma (EPC) is a rare breast malignancy with a slow growth rate and excellent prognosis. Case Series: There were two cases of EPC, one of them was a 60-year-old female presenting with two lumps in the right breast at 3 o’clock and 9 o’clock positions. A right modified radical mastectomy with axillary dissection was done subsequently. On histopathology EPC was diagnosed. The other case was of a 45-year-old female presenting with bloody nipple discharge and a 2-cm subareolar lump. Histopathology revealed features of EPC with invasion into the fibrous capsule. In both cases, there was no associated ductal carcinoma in situ (DCIS) in the surrounding tissue and lymph nodes were not involved. Conclusion: Encapsulated papillary carcinoma is a rare breast malignancy with excellent prognosis. In the absence of associated DCIS in the surrounding tissue or areas of infiltrating carcinoma, it has a very favorable prognosis with adequate local therapy alone. Niharika Shah1, Santosh Upadhyaya Kafle2, Punam Paudyal3 Affiliations: 1MD Pathology, Assistant Professor, Department of Pathology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal; 2MD Pathology, Fellowship Dermatopathology, Associate Professor, Department of Pathology, Birat Medical College, Biratnagar, Nepal; 3MD Pathology, Associate Professor, Department of Pathology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Corresponding Author: Niharika Shah, Assistant Professor, Department of Pathology, BPKIHS, Ghopa Camp, Dharan, Nepal, 56700; Email: niharika.shah@bpkihs.edu Received: 15 January 2017 Accepted: 07 March 2017 Published: 25 March 2017