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Purushothaman K-Raman

Icahn School of Medicine at Mount Sinai

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Featured researches published by Purushothaman K-Raman.

Therapeutic Advances in Cardiovascular Disease | 2018

Intravascular ultrasound guided directional atherectomy versus directional atherectomy guided by angiography for the treatment of femoropopliteal in-stent restenosis

Prakash Krishnan; Arthur Tarricone; Purushothaman K-Raman; Farhan Majeed; Vishal Kapur; Karthik Gujja; Jose Wiley; Miguel Vasquez; Rheoneil A. Lascano; Katherine G. Quiles; Tashanne Distin; Ran Fontenelle; Farah Atallah-Lajam; Annapoorna Kini; Samin K. Sharma

Background: The aim of this study was to compare 1-year outcomes for patients with femoropopliteal in-stent restenosis using directional atherectomy guided by intravascular ultrasound (IVUS) versus directional atherectomy guided by angiography. Methods and results: This was a retrospective analysis for patients with femoropopliteal in-stent restenosis treated with IVUS-guided directional atherectomy versus directional atherectomy guided by angiography from a single center between March 2012 and February 2016. Clinically driven target lesion revascularization was the primary endpoint and was evaluated through medical chart review as well as phone call follow up. Conclusions: Directional atherectomy guided by IVUS reduces clinically driven target lesion revascularization for patients with femoropopliteal in-stent restenosis.

Journal of the American College of Cardiology | 2012

CHORDAL RUPTURE CORRELATES WITH ELASTIC FIBRIL FRAGMENTATION AND DISORGANIZATION OF THE POSTERIOR LEAFLET IN MYXOMATOUS MITRAL VALVE PROLAPSE: IMPLICATIONS FOR LEAFLET STABILITY AND DISEASE PROGRESSION

Purushothaman K-Raman; Meerarani Purushothaman; David J. Adams; Federico Milla; Patrick A. Lento; William N. O'Connor; Samin K. Sharma; Valentin Fuster; Pedro R. Moreno

Mitral valve leaflet stability is maintained by extra-cellular matrix and valvular interstitial cells (VICs). In myxomatous mitral valve prolapse (MMVP), decreased type I collagen and increased type III collagen and proteoglycan deposition as a result of reduced lysyl oxidase (LOX) expression may

Journal of Molecular and Cellular Cardiology | 2011

Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats.

Elie R. Chemaly; Lahouaria Hadri; Shihong Zhang; Maengjo Kim; Erik Kohlbrenner; Jipo Sheng; Lifan Liang; Jiqiu Chen; Purushothaman K-Raman; Roger J. Hajjar; Djamel Lebeche

Jacc-cardiovascular Imaging | 2018

Combined PET/DCE-MRI in a Rabbit Model of Atherosclerosis: Integrated Quantification of Plaque Inflammation, Permeability, and Burden During Treatment With a Leukotriene A4 Hydrolase Inhibitor

Claudia Calcagno; Olivier Lairez; Julie Hawkins; Steven Kerr; Melanie S. Dugas; Thomas Simpson; Jelle Epskamp; Philip M. Robson; Mootaz Eldib; Ilda Bander; Purushothaman K-Raman; Alison N Pruzan; Audrey E Kaufman; Venkatesh Mani; Alexander Ehlgen; Heiko G. Niessen; John Alan Broadwater; Zahi A. Fayad

Journal of the American College of Cardiology | 2012

REDUCED LYSYL OXIDASE EXPRESSION IS ASSOCIATED WITH REDUCED TYPE I COLLAGEN AND INCREASED TYPE III COLLAGEN DEPOSITION IN MYXOMATOUS MITRAL VALVE DEGENERATION

Meerarani Purushothaman; Purushothaman K-Raman; David J. Adams; Federico Milla; Patrick A. Lento; Richard R. Peralta; Samin K. Sharma; Pedro R. Moreno

Journal of the American College of Cardiology | 2010

INCREASED ANGIOTENSIN CONVERTING ENZYME IS ASSOCIATED WITH INCREASED INFLAMMATION AND NEOVASCULARIZATION IN PERIPHERAL VASCULAR DISEASE: MECHANISTIC ROLE OF ANGIOTENSIN II TYPE I RECEPTOR, INTERLEUKIN-6, AND TUMOR NECROSIS FACTOR ALPHA IN DIABETIC ATHEROSCLEROSIS

Purushothaman K-Raman; Prakash Krishnan; Fernando Ruiz; Meerarani Purushothaman; Jose Wiley; Yelena Zubatov; Annapoorna Kini; Samin K. Sharma; John T. Fallon; Valentin Fuster; Pedro R. Moreno

Journal of the American College of Cardiology | 2017

PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 PROTEIN EXPRESSION IS INCREASED IN LIPID RICH HUMAN ATHEROSCLEROTIC PLAQUES COMPARED TO FIBROUS PLAQUES

Purushothaman K-Raman; Meerarani Purushothaman; Prakash Krishnan; Usman Baber; Urooz Zafar; Annapoorna Kini; Samin K. Sharma; Juan J. Badimon; Valentin Fuster; Pedro R. Moreno

Journal of the American College of Cardiology | 2017

MORPHOLOGICAL FEATURES OF VASCULAR HEALING IN PACLITAXEL COATED BALLOON COMPARED TO PLAIN OLD BALLOON ANGIOPLASTY IN HUMAN PERIPHERAL ARTERY DISEASE

Purushothaman K-Raman; Meerarani Purushothaman; Baber Usman; Arthur Tarricone; Miguel Vasquez; Annapoorna Kini; Samin K. Sharma; Pedro R. Moreno; Prakash Krishnan

Circulation | 2015

Abstract 15275: Altered Extracellular Matrix Proteoglycan- Decorin, Collagens and Elastin Deposition May Enhance Atherosclerosis in Human Peripheral Artery Disease: Implication of Morphological Predictors in Restenotic Plaque Progression

Prakash Krishnan; Purushothaman K-Raman; Meerarani Purushothaman; Jason C. Kovacic; Usman Baber; Arthur Tarricone; Miguel Vasquez; Jose Wiley; Annapoorna Kini; Samin K. Sharma; Valentin Fuster; Pedro R. Moreno

Circulation | 2014

Abstract 18925: Enhanced Cellular Proliferation and Altered Collagen Deposition May Accelerate Atherosclerosis in Human Peripheral Artery Disease: Implication of Morphological Predictors in Restenotic Plaque Progression

Prakash Krishnan; Purushothaman K-Raman; Meerarani Purushothaman; Jason C. Kovacic; Arthur Tarricone; Miguel Vasquez; Wiley Jose; Annapoorna Kini; Samin K. Sharma; Valentin Fuster; Pedro R. Moreno

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