Purvi Shah
Incyte
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Publication
Featured researches published by Purvi Shah.
Seminars in Liver Disease | 1998
Henry Yue; Neil C. Corley; Purvi Shah
Human glutathione S-transferases (GSTs) are a functionally diverse family of soluble enzymes of detoxification that use reduced glutathione (GSH) in conjugation and reduction reactions. Toxic electrophiles, including a variety of carcinogens, are substrates for the GSTs and after conjugation or reduction they are more easily excreted into bile or urine. Many of the GSTs have been cloned, and the three-dimensional structures of GSTs from several species, including humans, have been determined. These data have provided significant insight into how the GSTs function as enzymes. Many GST substrates are inducers of GST gene expression; nonsubstrate inducers include H2O2 and other reactive oxygen species. The regulatory elements of several human GST genes have been partially characterized, and the regulation of the GSTs in humans appears to be very different from that in rodents. Several polymorphisms of GST expression occur commonly in humans and have been associated with an increased susceptibility to certain cancers, particularly when combined with other genetic and environmental factors such as smoking. The role of GSTs in protecting cells from injury by toxic electrophiles continues to be developed.
Archive | 1999
Preeti Lal; Jennifer L. Hillman; Neil C. Corley; Karl J. Guegler; Mariah R. Baughn; Susan K. Sather; Purvi Shah
Archive | 1999
Jennifer L. Hillman; Purvi Shah; Neil C. Corley
Archive | 1999
Preeti Lal; Jennifer L. Hillman; Olga Bandman; Purvi Shah; Janice Au-Young; Henry Yue; Karl J. Guegler; Neil C. Corley
Archive | 1999
Olga Bandman; Jennifer L. Hillman; Henry Yue; Karl J. Guegler; Neil C. Corley; Y. Tom Tang; Purvi Shah
Archive | 1997
Jennifer L. Hillman; Neil C. Corley; Purvi Shah
Archive | 1997
Olga Bandman; Karl J. Guegler; Neil C. Corley; Purvi Shah
Archive | 2004
Preeti Lal; Olga Bandman; Jennifer L. Hillman; Purvi Shah; Neil C. Corley
Archive | 1998
Olga Bandman; Jennifer L. Hillman; Neil C. Corley; Karl J. Guegler; Preeti Lal; Surya K. Goli; Purvi Shah
Archive | 1997
Olga Bandman; Neil C. Corley; Purvi Shah