Putta Ramachandra Reddy

Synthesis and antioxidant activity of a new class of mono- and bis-heterocycles.

A new class of mono‐ and bis‐heterocycles, 2‐arylsulfonylaminosulfonylmethyl‐5‐styrylsulfonylmethyloxadiazoles, pyrazolyl oxadiazoles, and isoxazolyl oxadiazoles, were synthesized and tested for their antioxidant activity. The styrylsulfonylmethyloxadiazole 5b showed good antioxidant activity when compared with the standard ascorbic acid.

Synthesis and antimicrobial activity of 3-aroyl-4-heteroaryl pyrroles and pyrazoles

Abstract A variety of bis heterocycles-heteroaryl pyrazoles (5) and pyrroles (6) were prepared from heteroaryl chalcones adopting 1,3-dipolar cycloaddition reaction and studied their antimicrobial activity. The compounds 5d and 5f having bromo and nitro substituents on the aromatic ring are the potent antimicrobial agents against Bacillus subtilis and Aspergillus niger.

Synthesis, Antioxidant, and Cytotoxic Activities of N‐Azole Substituted Thiomorpholine Derivatives

A new class of N‐azole substituted thiomorpholine derivatives were prepared and their antioxidant and cytotoxic activities were studied. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited radical scavenging activity greater than the standard ascorbic acid. On the other hand, the thiazolyl thiomorpholine 10c having a chloro substituent on the aromatic ring was identified as a remarkable lead molecule for cytotoxic activity against A549 and HeLa cells, with IC50 values of 10.1 and 30.0 µM, respectively.