Qiao-Wen Chang

A novel water-soluble heptaplatin analogue with improved antitumor activity and reduced toxicity.

A novel water-soluble heptaplatin analogue, cis-[(4R,5R)-4,5-bis-(aminomethyl)-2-isopropyl-1,3-dioxolane](3-hydroxy-1,1-cyclobutanedicarboxylato)platinum(II), has been synthesized and biologically evaluated. The complex shows more activity and less toxicity than its parent drug heptaplatin, exhibiting the great potential for further development.

Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex

An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH(3))(2)I(2)] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent.

Synthesis and crystal structures of mononuclear iridium (III) acetylacetonate complexes bearing an axial bipyridine ligand

Three new iridium (III) acetylacetonate complexes with an axial bipyridine ligand were synthesised via the direct reaction of [bis(acac-O,O′)(acac-C3)Ir(H2O)] and the corresponding bipyridine, and their molecular structures were determined by using single-crystal X-ray diffraction. The bipyridine used was di-2-pyridylketone, 2,2′-bipyridine and 2,2′-bipyridylamine, respectively. The results revealed that only mononuclear iridium complexes were obtained, although bipyridine has two N coordinate atoms, probably due to the great steric hindrance existing around the coordinate sphere if two bis(acac-O,O′)(acac-C3)Ir units were bridged by bipyridine. All these complexes are coordinated in one axial direction by bipyridine as a mono-dentate ligand in a slightly distorted octahedral coordination geometry.

Crystal structure of Ir(acac-O,O)2(acac-C3)(pyridine)

Ir(acac-O,O)2(acac-C3)(pyridine), 1 is synthesized, and its crystal structure is determined by single crystal X-ray diffraction. In the complex, the central Ir(III) atom displays a distorted octahedral geometry wherein the equatorial positions are occupied by four oxygen atoms of two acetylacetone ligands, and the apical positions are coordinated by a carbon atom of one acetylacetone ligand and a nitrogen atom of pyridine.

The influence of sodium and barium ions on the structures of iridium (III) acetylacetonate complexes

Abstract Two iridium acetylacetonate complexes [Na(H2O)Ir(acac)2Cl2]n (compound1) and [Ba(H2O)5Ir(acac)2Cl2Ba(H2O)5][Ir(acac)2Cl2]3·2H2O (compound2) were synthesized and characterized by single-crystal X-ray diffraction, elemental analysis, NMR, IR, and absorption spectra. The influence of sodium and barium ions on their molecular structures was explored.

Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}

Abstract A new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)} has been synthesized, characterized by elemental analysis, MS, IR, and 1H, 13C NMR, and evaluated for in vitro anticancer activity in four human cancer cell lines. The stability of the derivative in water was also investigated by monitoring the changes of 1H NMR in D2O. The results reveal that the new derivative has good solubility and stability in water and also shows high anticancer activity against gastric cancer cells, ovarian cancer cells, and colon cancer cells. Therefore, it is worthy of further evaluation for in vivo antitumor activity and toxicity.

Synthesis and In Vitro cytotoxicity of Cis-[Pt(NH3)(NH2OH)Cl2]

A novel mixed NH3/NH2OH platinum(II) complex cis-[Pt(NH3)(NH2OH)Cl2] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and 1H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin.

Bis(acetyl­acetonato-κ2O,O′)­aqua­(diacetyl­methanido-κC)iridium(III)

In the crystal structure of the title compound, [Ir(C5H7O2)3(H2O)], the IrIII atom is six-coordinated and situated in a slightly distorted octahedral environment. The complex contains both Ir—O and Ir—C bonds and was isolated from a reaction mixture of IrCl3(H2O)x, pentane-2,5-dione and NaHCO3. O—H⋯O hydrogen bonding between the water molecules and the carbonyl O atoms of adjacent molecules leads to a layered motif extending parallel to (010).

Crystal structure of iridium(III) acetylacetonate complexes bearing axial bromide-substituted pyridine

Two iridium acetylacetonate complexes bearing axial bromide-substituted pyridine (3-bromopyridine, 1 and 4-bromopyridine, 2) are synthesized and their crystal structures are determined by single crystal X-ray diffraction. In both complexes, a distorted octahedral geometry of the central Ir(III) atom is formed by four oxygen atoms of two acetylacetone ligands, a carbon atom of one acetylacetone ligand, and a nitrogen atom of bromide-substituted pyridine.

Crystal structures of tetrakis (hydroxyacetato)bis(dimethylsulfoxide) dirhodium(II)

Tetrakis(hydroxyacetato)bis(dimethyl sulfoxide)dirhodium(II) (1) is synthesized by the reaction of dimethyl sulfoxide (DMSO) with Rh2(OOCCH2OH)4. The complex is characterized by elemental analysis, FT-IR, ESI+-MS, 1H and 13C NMR, along with single crystal X-ray diffraction. The ambidentate DMSO ligands are bound to the rhodium center of 1 through their sulfur atoms, which is firstly predicated by its orange color, then confirmed by the observation of an increase in the S–O stretching frequencies, and finally, unambiguously determined by single crystal X-ray diffraction. The structure of 1 contains two similar but crystallographically independent molecules. Both molecules contain lantern dirhodium units, joined equatorially by four bidentate hydroxyacetate ligands and two monodentate DMSO axial ligands. Four hydrogen bonds link the molecules together with d(O⋯O) of 2.767(4)-2.824(4) Å to form a three dimensional network.